Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 314 aa | 21.7 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 277 aa | 23.8 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 306 aa | 26.1 % |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A1 receptor | 326 aa | 316 aa | 19.3 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 296 aa | 22.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 318 aa | 22.3 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 326 aa | 20.2 % | |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 315 aa | 23.8 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % | |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 24.0 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 22.1 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 307 aa | 21.2 % | |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A1 receptor | 326 aa | 301 aa | 25.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 331 aa | 25.7 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 304 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0034 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0173 | 0.1177 | 0.5 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0173 | 0.1177 | 0.1177 |
Echinococcus multilocularis | Aminotransferase class III | 0.0173 | 0.1177 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.1214 | 1 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0173 | 0.1177 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | Aminotransferase class III | 0.0173 | 0.1177 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.1214 | 1 | 1 |
Mycobacterium ulcerans | acetylornithine aminotransferase | 0.0173 | 0.1177 | 0.1177 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.1214 | 1 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0173 | 0.1177 | 0.5 |
Mycobacterium ulcerans | ornithine aminotransferase RocD1 and RocD2 | 0.0173 | 0.1177 | 0.1177 |
Loa Loa (eye worm) | aminopeptidase N | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0173 | 0.1177 | 0.1177 |
Mycobacterium ulcerans | hypothetical protein | 0.1214 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | ornithine aminotransferase | 0.0173 | 0.1177 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0173 | 0.1177 | 1 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0173 | 0.1177 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0034 | 0 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0173 | 0.1177 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0034 | 0 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0173 | 0.1177 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | ornithine aminotransferase | 0.0173 | 0.1177 | 0.5 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.1214 | 1 | 1 |
Mycobacterium ulcerans | 4-aminobutyrate aminotransferase | 0.0173 | 0.1177 | 0.1177 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | glutamate-1-semialdehyde aminotransferase | 0.0173 | 0.1177 | 0.1177 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0173 | 0.1177 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.1 uM | Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane | ChEMBL. | 8071944 |
Ki (binding) | = 1.1 uM | Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane | ChEMBL. | 8071944 |
Ki (binding) | = 22.9 uM | Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane | ChEMBL. | 8071944 |
Ki (binding) | = 22.9 uM | Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane | ChEMBL. | 8071944 |
Ratio (binding) | = 21 | Ratio between the Ki values of A2 and A1 receptors | ChEMBL. | 8071944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.