Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0111 | 0.1086 | 0.32 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0206 | 0.3293 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.1933 | 0.581 |
Echinococcus multilocularis | insulin receptor | 0.0066 | 0.0048 | 0.0145 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0064 | 0.0014 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0147 | 0.1933 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0206 | 0.3293 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0064 | 0.0014 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0495 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0206 | 0.3293 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0066 | 0.0048 | 0.0145 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0064 | 0.0014 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0495 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.1086 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0111 | 0.1086 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.1059 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.1059 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0111 | 0.1086 | 0.3299 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0064 | 0.0014 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0495 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.1086 | 0.32 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0495 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0206 | 0.3293 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0495 | 1 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0495 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0206 | 0.3293 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0495 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0109 | 0.1059 | 0.3117 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0064 | 0.0014 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DNA cleavage (binding) | = 33 % | Normalized percent cleavage of DNA from cleavage reactions (20 h) containing 100 mM compound and 50 mM (bp) supercoiled DNA at pH 8.0 in 20 mM TRIS buffer | ChEMBL. | 11677138 |
DNA cleavage (binding) | = 42 % | Normalized percent cleavage of DNA from cleavage reactions (20 h) containing 100 mM compound and 50 mM (bp) supercoiled DNA at pH 9.0 in 20 mM TRIS buffer | ChEMBL. | 11677138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.