Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hexokinase family protein | 0.039 | 0.4311 | 0.4311 |
Plasmodium vivax | hexokinase, putative | 0.0621 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0621 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0621 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0621 | 1 | 1 |
Onchocerca volvulus | 0.0621 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0621 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0621 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0621 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.5146 | 0.5146 |
Echinococcus granulosus | hexokinase | 0.0621 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0621 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0621 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0621 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0621 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0621 | 1 | 1 |
Onchocerca volvulus | 0.0621 | 1 | 1 | |
Trypanosoma brucei | hexokinase, putative | 0.0621 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0621 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0621 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0621 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0621 | 1 | 1 |
Onchocerca volvulus | 0.0621 | 1 | 1 | |
Treponema pallidum | hexokinase (hxk) | 0.0621 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0621 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.039 | 0.4311 | 0.4311 |
Echinococcus granulosus | hexokinase type 2 | 0.0621 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0621 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0621 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0621 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0621 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0621 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15 nM | Inhibitory activity against human carbonic anhydrase II (CA2) | ChEMBL. | 10649985 |
Ki (binding) | = 15 nM | Inhibitory activity against human carbonic anhydrase II (CA2) | ChEMBL. | 10649985 |
Ki (binding) | = 49 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes | ChEMBL. | 10649985 |
Ki (binding) | = 49 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes | ChEMBL. | 10649985 |
Ki (binding) | = 470 nM | Inhibitory activity against human carbonic anhydrase I (CA1) | ChEMBL. | 10649985 |
Ki (binding) | = 470 nM | Inhibitory activity against human carbonic anhydrase I (CA1) | ChEMBL. | 10649985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.