TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 375.427 | Formula: C20H21N7O
H donors: 3 H acceptors: 4 LogP: 3.65 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Cc1noc(c1)CNc1nccc(n1)Nc1n[nH]c(c1)CCc1ccccc1
InChi: 1S/C20H21N7O/c1-14-11-17(28-27-14)13-22-20-21-10-9-18(24-20)23-19-12-16(25-26-19)8-7-15-5-3-2-4-6-15/h2-6,9-12H,7-8,13H2,1H3,(H3,21,22,23,24,25,26)
InChiKey: ZWCOUICPAQBKJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References
Homo sapiens	insulin-like growth factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0017	0.0161
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0074	0.0283	0.266
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0032	0.0017	0.0208
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	amine GPCR	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	tyrosine kinase	0.0071	0.0261	0.3172
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	serotonin receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	hypothetical protein	0.0032	0.0017	0.0017
Schistosoma mansoni	opsin-like receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Onchocerca volvulus		0.0167	0.086	0.9308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	opsin-like receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0032	0.0017	0.0017
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0017	0.0017
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.163	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Echinococcus granulosus	twitchin	0.0032	0.0017	0.0017
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0032	0.0017	0.0208
Brugia malayi	Protein kinase domain containing protein	0.009	0.038	0.3468
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0123	0.0585	0.0585
Echinococcus multilocularis	roundabout 2	0.0035	0.004	0.0023
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	G protein coupled receptor 139	0.0032	0.0017	0.0017
Schistosoma mansoni	tyrosine kinase	0.0123	0.0585	0.7124
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0358	0.3364
Schistosoma mansoni	tyrosine kinase	0.016	0.0821	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0074	0.0283	0.0266
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	somatostatin receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0123	0.0585	0.0585
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0123	0.0585	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	nephrin	0.0032	0.0017	0.0212
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0032	0.0017	0.0208
Echinococcus granulosus	7TM GPCR rhodopsin	0.0032	0.0017	0.0017
Brugia malayi	Furin-like cysteine rich region family protein	0.0074	0.0283	0.254
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0017	0.0161
Echinococcus granulosus	dro:myosuppressin receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	sex peptide receptor	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	TK/INSR protein kinase	0.016	0.0821	0.7724
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Echinococcus granulosus	neuropeptide FF receptor 2	0.0032	0.0017	0.0017
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0129	0.0625	0.5815
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0032	0.0017	0.0017
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0199	0.1063	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.016	0.0821	0.0805
Mycobacterium tuberculosis	Possible oxidoreductase	0.0452	0.2643	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0017	0.0208
Echinococcus granulosus	orexin receptor type 2	0.0032	0.0017	0.0017
Echinococcus granulosus	epidermal growth factor receptor	0.0074	0.0283	0.0283
Echinococcus granulosus	neuroglian	0.0032	0.0017	0.0017
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0017	0.0161
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0017	0.0017
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0199	0.1063	1
Schistosoma mansoni	tyrosine kinase	0.0074	0.0283	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	tyrosine kinase	0.0071	0.0261	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0032	0.0017	0.0017
Schistosoma mansoni	tyrosine kinase	0.0071	0.0261	0.3172
Onchocerca volvulus	Tyrosine kinase homolog	0.0177	0.0923	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	neuropeptide receptor A26	0.0032	0.0017	0.0017
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0017	0.0017
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0017	0.0161
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Schistosoma mansoni	adenoreceptor	0.0032	0.0017	0.0208
Schistosoma mansoni	amine GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	amine GPCR	0.0032	0.0017	0.0208
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0017	0.0161
Echinococcus multilocularis	insulin receptor	0.016	0.0821	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	hypothetical protein	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0074	0.0283	0.0283
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0017	0.0161
Schistosoma mansoni	tyrosine kinase	0.016	0.0821	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	epidermal growth factor receptor	0.0074	0.0283	0.0283
Echinococcus granulosus	insulin receptor	0.016	0.0821	0.0821
Schistosoma mansoni	hypothetical protein	0.0032	0.0017	0.0208
Schistosoma mansoni	histamine h1 receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	allatostatin A receptor	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	roundabout 2	0.0035	0.004	0.004
Schistosoma mansoni	amine GPCR	0.0032	0.0017	0.0208
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0017	0.0017
Echinococcus multilocularis	epidermal growth factor receptor	0.0074	0.0283	0.0266
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	g-protein coupled receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	amine GPCR	0.0032	0.0017	0.0208
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0017	0.0017
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.016	0.0821	0.0821
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0017	0.0161
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0035	0.004	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	neuropeptide s receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	tyrosine kinase	0.0074	0.0283	0.3444
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Brugia malayi	Protein kinase domain containing protein	0.016	0.0821	0.7687
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0123	0.0585	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0017	0.0208
Schistosoma mansoni	myosin xvIII	0.0032	0.0017	0.0208
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	TK protein kinase	0.0129	0.0625	0.5882
Schistosoma mansoni	growth hormone secretagogue receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	tyrosine kinase	0.0074	0.0283	0.3444
Echinococcus granulosus	7tm_1 domain containing protein	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	neuropeptide f receptor 76f	0.0032	0.0017	0.0208
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Echinococcus granulosus	fmrfamide receptor	0.0032	0.0017	0.0017
Schistosoma mansoni	opsin-like receptor	0.0032	0.0017	0.0208
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0017	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0017	0.0208
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0035	0.004	0.0379
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0017	0.0017
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0032	0.0017	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.8	Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobility shift assay	ChEMBL.	22612866
IC50 (binding)	= 6.9	Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility shift assay	ChEMBL.	22612866
IC50 (binding)	= 8.1	Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobility shift assay	ChEMBL.	22612866
Kd (binding)	= 67.9 nM	Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by surface plasmon resonance analysis	ChEMBL.	24900792
Kd (binding)	= 69.1 nM	Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by isothermal titration calorimetric analysis	ChEMBL.	24900792

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2088100

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1672174