Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Synaptic glycoprotein SC2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 254 aa | 208 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0189 | 0.0158 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0017 | 0.0017 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.5613 | 0.5928 | 0.5928 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0017 | 0.0017 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0.0158 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0017 | 0.0017 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0213 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | RNA binding protein | 0.0056 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0213 | 0.0183 | 0.0183 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0189 | 0.0158 | 0.0158 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0189 | 0.0158 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0056 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0158 | 0.0158 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0017 | 0.0017 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0.0158 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0213 | 0.0183 | 0.0183 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0.0158 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.9441 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0056 | 0.0017 | 0.0017 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0189 | 0.0158 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0.0158 | 0.5 |
Brugia malayi | RNA binding protein | 0.0056 | 0.0017 | 0.0017 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9441 | 1 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0189 | 0.0158 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0056 | 0.0017 | 0.0017 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0017 | 0.0017 |
Onchocerca volvulus | 0.9441 | 1 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0056 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | TAR-binding protein | 0.0056 | 0.0017 | 0.0017 |
Mycobacterium ulcerans | hypothetical protein | 0.0189 | 0.0158 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0189 | 0.0158 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.3828 | 0.4029 | 0.4029 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0056 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.9441 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22.1 nM | Inhibition of human type-2 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate after 30 mins by HPLC analysis | ChEMBL. | 22776417 |
Inhibition (binding) | = 32.3 % | Inhibition of human type-1 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate at 10 uM after 30 mins by HPLC analysis | ChEMBL. | 22776417 |
Inhibition (binding) | = 100 % | Inhibition of human type-2 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate at 2 uM after 30 mins by HPLC analysis | ChEMBL. | 22776417 |
Inhibition (binding) | = 100 % | Inhibition of human type-2 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate at 10 uM after 30 mins by HPLC analysis | ChEMBL. | 22776417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.