Detailed information for compound 1683291

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.788 | Formula: C19H16ClNO3
  • H donors: 1 H acceptors: 3 LogP: 4.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc2c1n(cc2CC(=O)O)C(=O)c1ccc(cc1)Cl
  • InChi: 1S/C19H16ClNO3/c1-2-12-4-3-5-16-14(10-17(22)23)11-21(18(12)16)19(24)13-6-8-15(20)9-7-13/h3-9,11H,2,10H2,1H3,(H,22,23)
  • InChiKey: HUUDENONFAELRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0136 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.021 0.3207 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0136 0.0425
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Leishmania major p-glycoprotein 0.0013 0.0136 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0136 0.0425
Schistosoma mansoni multidrug resistance protein 0.0013 0.0136 0.0425
Schistosoma mansoni multidrug resistance protein 0.0013 0.0136 0.0425
Trypanosoma cruzi multidrug resistance protein E, putative 0.0004 0 0.5
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0136 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0136 1
Schistosoma mansoni serine/threonine protein kinase 0.021 0.3207 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0136 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0136 1
Giardia lamblia MRP-like ABC transporter 0.0004 0 0.5
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0136 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0136 0.0425
Schistosoma mansoni smdr2 0.0013 0.0136 0.0425
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0134 0.0418
Trichomonas vaginalis taga, putative 0.0013 0.0136 1
Brugia malayi map kinase activated protein kinase protein 2 0.021 0.3207 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0076 0.5606
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0136 0.0425
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0136 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0136 1
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.0076 0.0238
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0136 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0136 0.0425
Loa Loa (eye worm) hypothetical protein 0.0013 0.0134 0.0418
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0136 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0136 1
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0076 0.0238
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0004 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Trypanosoma brucei p-glycoprotein 0.0004 0 0.5
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Onchocerca volvulus 0.0013 0.0136 0.5
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0004 0 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0136 0.0425
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0136 0.0425
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0136 0.0425
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0136 0.0425
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.021 0.3207 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0136 1
Giardia lamblia ABC transporter, putative 0.0004 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0076 0.0238
Brugia malayi ABC transporter family protein 0.0013 0.0136 0.0425
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0004 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0136 1
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0004 0 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0136 0.0425
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0136 0.0425
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0136 1
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0004 0 0.5
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0136 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0136 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0136 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0136 0.0425
Trichomonas vaginalis abcb9, putative 0.0013 0.0136 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0136 0.0425
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0136 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0136 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0 0.5
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0136 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0136 0.0425
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0136 1
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0136 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.021 0.3207 1
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0136 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0136 0.0425
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0136 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0136 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0134 0.0418
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0136 0.0425
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0136 0.0425
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0136 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0136 0.0425
Trypanosoma brucei multidrug resistance protein E 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0136 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0136 0.0425
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0136 1
Brugia malayi multidrug resistance protein 3 0.0013 0.0136 0.0425

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 uM Inhibition of human recombinant P-glycoprotein after 40 mins by Pgp-Glo assay ChEMBL. 22916727
IC50 (binding) > 400 uM Inhibition of ovine COX2 by colorimetric assay ChEMBL. 22916727
IC50 (binding) > 400 uM Inhibition of ovine COX1 by colorimetric assay ChEMBL. 22916727
Inhibition (binding) Inhibition of human MRP1 in human T98G cells assessed as potentiation of doxorubicin induced cytotoxicity at 50 uM pre-incubated for 2 hrs before doxorubicin addition and measured 4 days after doxorubicin exposure by MTT assay relative to untreated control ChEMBL. 22916727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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