Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0115 | 0.056 | 0.094 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0153 | 0.0846 | 0.1631 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0424 | 0.2888 | 0.2888 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0522 | 0.3627 | 0.6087 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0424 | 0.2888 | 0.4846 |
Brugia malayi | mbt repeat family protein | 0.0441 | 0.3017 | 0.5816 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0052 | 0.0083 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0729 | 0.5188 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0614 | 0.4319 | 0.4319 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0831 | 0.5958 | 1 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0043 | 0.0019 | 0.0032 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0614 | 0.4319 | 0.7248 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0218 | 0.1341 | 0.2556 |
Loa Loa (eye worm) | MBCTL1 | 0.0153 | 0.0846 | 0.16 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0115 | 0.056 | 0.1079 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0107 | 0.0503 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0218 | 0.1341 | 0.2584 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0182 | 0.1066 | 0.1789 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0148 | 0.0813 | 0.0813 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0043 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0115 | 0.056 | 0.1046 |
Brugia malayi | mbt repeat family protein | 0.0729 | 0.5188 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0124 | 0.0626 | 0.1051 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0831 | 0.5958 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0153 | 0.0846 | 0.0846 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0125 | 0.0639 | 0.0639 |
Echinococcus granulosus | chromobox protein 2 | 0.0314 | 0.2063 | 0.3462 |
Toxoplasma gondii | PLU-1 family protein | 0.007 | 0.0222 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0522 | 0.3627 | 0.6087 |
Echinococcus granulosus | histone acetyltransferase myst3 | 0.0065 | 0.0184 | 0.0309 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0182 | 0.1066 | 0.1789 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0446 | 0.0825 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0729 | 0.5188 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0125 | 0.0639 | 0.0639 |
Brugia malayi | CHD4 protein | 0.0043 | 0.0019 | 0.0037 |
Echinococcus multilocularis | chromobox protein 2 | 0.0314 | 0.2063 | 0.3462 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0107 | 0.0503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.3627 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0846 | 0.16 |
Schistosoma mansoni | phd finger protein | 0.0065 | 0.0184 | 0.0184 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0153 | 0.0846 | 0.142 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0115 | 0.056 | 0.094 |
Schistosoma mansoni | chromobox protein | 0.0314 | 0.2063 | 0.2063 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0148 | 0.0813 | 0.1364 |
Echinococcus multilocularis | histone acetyltransferase myst3 | 0.0065 | 0.0184 | 0.0309 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0043 | 0.0019 | 0.0032 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0441 | 0.3017 | 0.58 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0148 | 0.0813 | 0.0813 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0046 | 0.0044 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0153 | 0.0846 | 0.142 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0424 | 0.2888 | 0.4846 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0614 | 0.4319 | 0.7248 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0153 | 0.0846 | 0.142 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0153 | 0.0846 | 0.142 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0424 | 0.2888 | 0.2888 |
Plasmodium vivax | JmjC domain containing protein | 0.0046 | 0.0044 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 uM | Inhibition of urokinase receptor binding to uPA amino terminal fragment by ELISA | ChEMBL. | 22771232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.