Detailed information for compound 1690263

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.889 | Formula: C21H17ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.19 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1C(Nc2c(C1=O)cccc2)c1ccc(cc1)S(=O)(=O)C
  • InChi: 1S/C21H17ClN2O3S/c1-28(26,27)17-12-6-14(7-13-17)20-23-19-5-3-2-4-18(19)21(25)24(20)16-10-8-15(22)9-11-16/h2-13,20,23H,1H3
  • InChiKey: PXLREINNKDOJGV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0045 0.074 0.7154
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0083 0.1625 0.6533
Loa Loa (eye worm) sugar transporter 0.0102 0.209 0.4804
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.022 0.4913 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0813 0.3267
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0408 0.1641
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0196 0.0789
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0196 0.054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0803 0.3185
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0114 0.4688
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0157 0.038
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0408 0.1415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0157 0.0571
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0119 0.2488 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0018 0.0092 0.0155
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.0863
Schistosoma mansoni glucose transport protein 0.0102 0.209 0.4235
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Giardia lamblia GTOR 0.0056 0.0997 0.9246
Entamoeba histolytica hypothetical protein 0.0035 0.0483 0.1631
Brugia malayi hypothetical protein 0.0035 0.0483 0.1888
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0157 0.0719
Schistosoma mansoni hypothetical protein 0.0102 0.209 0.4235
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0018 0.0092 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Leishmania major glucose transporter, lmgt1 0.0032 0.0408 0.349
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0384 0.2161
Trypanosoma brucei glucose transporter 1E 0.0032 0.0408 0.349
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0018 0.0092 0.0212
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0416 0.1672
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0119 0.2488 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0399 0.0781
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0141
Entamoeba histolytica protein kinase, putative 0.0031 0.0399 0.1279
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0492 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0481 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0408 0.1641
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3592 0.3552
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0399 0.0781
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0415 0.1668
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Schistosoma mansoni protein kinase 0.0031 0.0399 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0157 0.0633
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0997 0.2292
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.022 0.4913 1
Plasmodium falciparum hexose transporter 0.0102 0.209 0.2041
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0018 0.0092 0.0141
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0655 0.2348
Toxoplasma gondii protein kinase, putative 0.0288 0.6541 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0045 0.074 0.2784
Brugia malayi AMP-binding enzyme family protein 0.0023 0.02 0.0742
Leishmania major glucose transporter, lmgt2 0.0032 0.0408 0.349
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0399 0.034
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0803 0.1847
Loa Loa (eye worm) hypothetical protein 0.0031 0.0399 0.0916
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0157 0.0288
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0505 0.4556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0384 0.075
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0018 0.0092 0.0155
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0353 0.0686
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0655 0.2584
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0408 0.349
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0408 0.349
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0399 0.1547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0739 0.297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0157 0.0633
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.02 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0353 0.0686
Echinococcus multilocularis Zinc finger, PHD finger 0.0018 0.0092 0.0155
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0384 0.1486
Toxoplasma gondii target of rapamycin (TOR), putative 0.0043 0.0674 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0489 0.1965
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0399 0.061
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0196 0.1148
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Echinococcus granulosus General substrate transporter 0.0088 0.1747 0.3535
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0018 0.0092 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.1517 0.6074
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0384 0.075
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0056 0.0997 0.3778
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0384 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0018 0.0092 0.0155
Entamoeba histolytica hypothetical protein 0.0035 0.0483 0.1631
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0056 0.0997 0.3848
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0196 0.0136
Loa Loa (eye worm) hypothetical protein 0.0031 0.0384 0.0882
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0399 0.061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0018 0.0092 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0505 0.4556
Entamoeba histolytica protein kinase, putative 0.0031 0.0399 0.1279
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0112 0.2325 0.9319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0997 0.4009
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0018 0.0092 0.0111
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.02 1
Echinococcus granulosus geminin 0.0164 0.3566 0.7248
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.02 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Plasmodium vivax hexose transporter 0.0102 0.209 0.2041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0246 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0399 0.1603
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0554 0.2227
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0492 0.176
Schistosoma mansoni hypothetical protein 0.0164 0.3566 0.7248
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.02 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0196 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0157 0.0288
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0399 0.034
Loa Loa (eye worm) hypothetical protein 0.0023 0.02 0.0459
Loa Loa (eye worm) hypothetical protein 0.0023 0.02 0.0459
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.022 0.4913 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0408 0.349
Onchocerca volvulus 0.0023 0.02 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0259 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0408 0.1641
Trypanosoma brucei glucose transporter 2A 0.0032 0.0408 0.349
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0384 0.075
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0384 0.1542
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0119 0.2488 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.02 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0803 0.3185
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0016 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0061 0.139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0129 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0739 0.297
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.02 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0056 0.0997 0.2003
Leishmania major glucose transporter, lmgt3 0.0032 0.0408 0.349
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0083 0.1625 0.6533
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0483 0.0953
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0119 0.2488 1
Brugia malayi MH2 domain containing protein 0.0115 0.2409 0.9683
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0018 0.0092 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0073 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0157 0.0633
Loa Loa (eye worm) hypothetical protein 0.0031 0.0384 0.0882
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.02 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0505 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0481 0.1935
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0114 0.4688
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0399 0.0916
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0196 0.1148
Entamoeba histolytica hypothetical protein 0.0023 0.0196 0.0434
Loa Loa (eye worm) phosphatidylinositol 3 0.0197 0.4351 1
Entamoeba histolytica hypothetical protein 0.0095 0.1925 0.7652
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0655 0.2633
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.0655 0.2434
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0505 0.1814
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0655 0.2633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0489 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0739 0.297
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0655 0.2633
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0056 0.0997 1
Brugia malayi Sugar transporter family protein 0.0102 0.209 0.8392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0416 0.1672
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.02 0.1185
Brugia malayi Cam kinase protein 1 0.0031 0.0399 0.1547
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0018 0.0092 0.0031
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0399 0.034
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.209 0.3196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0674 0.2708
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0056 0.0997 0.2003
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2409 0.5538
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0056 0.0997 1
Echinococcus multilocularis geminin 0.0164 0.3566 0.7248
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0505 0.1814
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0196 0.03
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0408 0.349
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0196 0.9757
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0157 0.0719
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0157 0.0288
Schistosoma mansoni protein kinase 0.0031 0.0399 0.0781
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.209 0.4235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0997 0.4009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0038
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3592 0.5492
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0119 0.2488 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.02 0.0448
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.209 0.4235
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0384 0.1486
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0196 0.0367
Plasmodium falciparum protein kinase 7 0.0288 0.6541 0.6519
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3592 0.3552
Echinococcus multilocularis General substrate transporter 0.0088 0.1747 0.3535
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0059 0.1063 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.1925 0.7652
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0399 0.034
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0384 0.1216
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0997 0.397
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0955 0.3601
Schistosoma mansoni hypothetical protein 0.0164 0.3566 0.7248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0416 0.1672
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.02 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.02 0.1185
Schistosoma mansoni hypothetical protein 0.0035 0.0483 0.0953
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1847
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0018 0.0092 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0408 0.1641
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.003 0.0378 0.2093
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0439 0.1711
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0399 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0997 0.4009
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0196 0.0367
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0119 0.2488 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0416 0.1672
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.02 0.3171
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0408 0.1415
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0056 0.0997 0.3778
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0655 0.1304
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0505 0.4556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0415 0.1668
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0018 0.0092 0.0155
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0505 0.0772
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0399 0.0916
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0655 0.2348
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0483 0.0953
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0196 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0581 0.2337
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.02 0.1185
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0408 0.1641
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0141
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.02 0.3171
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0101 0.2078 0.8342
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0399 0.034
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.02 0.0448
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0056 0.0997 0.3848
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0408 0.1641
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.0655 0.6215
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0157 0.0362
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0028 0.0331 0.264
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0399 0.061
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0384 0.075
Trypanosoma cruzi hexose transporter 0.0032 0.0408 0.1415
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0408 0.1415
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0196 0.0728
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0399 0.034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0018 0.0092 0.0372
Loa Loa (eye worm) hypothetical protein 0.0041 0.0622 0.1431
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0141
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0196 0.9757
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0119 0.2488 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0045 0.074 0.7154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0739 0.297
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.02 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0157 0.0719
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0196 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.209 0.8402
Entamoeba histolytica hypothetical protein 0.0035 0.0483 0.1631
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Leishmania major protein kinase, putative 0.0031 0.0399 0.3384
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0056 0.0997 0.2003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0056 0.0997 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0399 0.034
Entamoeba histolytica hypothetical protein 0.0035 0.0483 0.1631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0157 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0489 0.1965
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0018 0.0092 0.0155
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0483 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0157 0.0633
Loa Loa (eye worm) hypothetical protein 0.0023 0.02 0.0459
Schistosoma mansoni glucose transport protein 0.0102 0.209 0.4235
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0157 0.038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0141
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0399 0.034
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0018 0.0092 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.02 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.0997 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1517 0.3488
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0196 0.0367
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.02 0.0448
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0196 0.3046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.1009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0157 0.0719
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0399 0.0781
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Trypanosoma brucei glucose transporter, putative 0.0032 0.0408 0.349
Brugia malayi AMP-binding enzyme family protein 0.0023 0.02 0.0742
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0408 0.1641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0415 0.1668
Brugia malayi AMP-binding enzyme family protein 0.0023 0.02 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0739 0.297
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0399 0.3384
Schistosoma mansoni protein kinase 0.0031 0.0399 0.0781
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.1517 0.3065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0141
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0505 0.0446
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.1517 0.3065
Schistosoma mansoni glucose transport protein 0.0102 0.209 0.4235
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2409 0.5538

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of ovine COX1 peroxidase activity assessed as TMPD oxidation at 20 uM by colorimetric analysis ChEMBL. 23146282
Inhibition (binding) = 100 % Inhibition of ovine COX2 peroxidase activity assessed as TMPD oxidation at 20 uM by colorimetric analysis ChEMBL. 23146282

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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