Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0903 | 0.2029 | 0.473 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0903 | 0.2029 | 0.473 |
Schistosoma mansoni | choline o-acyltransferase | 0.0396 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0903 | 0.2029 | 0.2029 |
Onchocerca volvulus | 0.0396 | 0 | 0.5 | |
Onchocerca volvulus | 0.0396 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0903 | 0.2029 | 0.473 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1467 | 0.4289 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1467 | 0.4289 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1467 | 0.4289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2893 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0903 | 0.2029 | 0.473 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1467 | 0.4289 | 1 |
Onchocerca volvulus | 0.0396 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1467 | 0.4289 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0903 | 0.2029 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0396 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0903 | 0.2029 | 0.2029 |
Onchocerca volvulus | 0.0396 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC30 (ADMET) | > 60 uM | Compound was tested for its toxicity by using MTT toxicity assay. | ChEMBL. | 9685236 |
IC50 (functional) | = 50 nM | Inhibitory activity against HIV-1 IIIB replication in C8166 cells. | ChEMBL. | 9685236 |
IC50 (functional) | = 50 nM | Inhibitory activity against HIV-1 IIIB replication in C8166 cells. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.01 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase V106A | ChEMBL. | 9685236 |
IC50 (binding) | = 0.01 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase V106A | ChEMBL. | 9685236 |
IC50 (binding) | = 0.02 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase K103N | ChEMBL. | 9685236 |
IC50 (binding) | = 0.02 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase K103N | ChEMBL. | 9685236 |
IC50 (binding) | = 0.06 uM | Inhibitory activity against HIV-1 Y181C reverse transcriptase. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.06 uM | Inhibitory activity against HIV-1 Y181C reverse transcriptase. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.08 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase G190A | ChEMBL. | 9685236 |
IC50 (binding) | = 0.08 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase G190A | ChEMBL. | 9685236 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against HIV-1 wild-type reverse transcriptase. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against HIV-1 wild-type reverse transcriptase. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.21 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236L | ChEMBL. | 9685236 |
IC50 (binding) | = 0.21 uM | Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236L | ChEMBL. | 9685236 |
IC50 (binding) | = 0.64 uM | Inhibitory activity against HIV-1 Y188L reverse transcriptase. | ChEMBL. | 9685236 |
IC50 (binding) | = 0.64 uM | Inhibitory activity against HIV-1 Y188L reverse transcriptase. | ChEMBL. | 9685236 |
IC90 (functional) | = 113 nM | Inhibitory activity against HIV-1 IIIB replication in C8166 cells. | ChEMBL. | 9685236 |
IC90 (functional) | = 113 nM | Inhibitory activity against HIV-1 IIIB replication in C8166 cells. | ChEMBL. | 9685236 |
Metabolism (ADMET) | = 171 pM min-1 | In vitro metabolism of the compound in human liver microsomes | ChEMBL. | 9685236 |
Metabolism (ADMET) | = 171 pM min-1 | In vitro metabolism of the compound in human liver microsomes | ChEMBL. | 9685236 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9685236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.