Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0593 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1138 | 0.1081 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.6934 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0017 | 0.0543 | 0.0304 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0593 | 0.038 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Echinococcus multilocularis | geminin | 0.0098 | 0.6936 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0023 | 0.1081 | 0.128 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0014 | 0.0343 | 0.018 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Brugia malayi | MH2 domain containing protein | 0.0071 | 0.4835 | 0.5562 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.0757 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0019 | 0.0756 | 0.0757 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0025 | 0.1184 | 0.1362 |
Brugia malayi | Peptidase family M1 containing protein | 0.0019 | 0.0756 | 0.087 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0017 | 0.0593 | 0.0552 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.6878 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0029 | 0.1532 | 0.1231 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.4877 | 0.5495 |
Onchocerca volvulus | 0.0017 | 0.0593 | 0.0259 | |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0072 | 0.4877 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0072 | 0.4877 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0015 | 0.0419 | 0.0423 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0029 | 0.1532 | 0.1951 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.6936 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0025 | 0.1184 | 0.1276 |
Brugia malayi | Pre-SET motif family protein | 0.0017 | 0.0593 | 0.0682 |
Brugia malayi | Peptidase family M1 containing protein | 0.0019 | 0.0756 | 0.087 |
Brugia malayi | Pre-SET motif family protein | 0.012 | 0.8694 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.1148 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0025 | 0.1184 | 0.1433 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0019 | 0.0756 | 0.0796 |
Onchocerca volvulus | 0.0019 | 0.0756 | 0.0428 | |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.0757 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0756 | 0.087 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0023 | 0.1081 | 0.128 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0072 | 0.4877 | 0.6934 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.012 | 0.8694 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.6936 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0072 | 0.4877 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0015 | 0.0419 | 0.0423 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0072 | 0.4877 | 0.6878 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.561 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0419 | 0.0482 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0071 | 0.4835 | 0.5446 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0014 | 0.0343 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0019 | 0.0756 | 0.0796 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0019 | 0.0756 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0014 | 0.0343 | 0.0142 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0071 | 0.4835 | 0.5446 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0419 | 0.0232 |
Echinococcus granulosus | aminopeptidase N | 0.0019 | 0.0756 | 0.0627 |
Plasmodium vivax | SET domain protein, putative | 0.0017 | 0.0593 | 0.0552 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Brugia malayi | brahma associated protein 60 kDa | 0.0014 | 0.0343 | 0.0394 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0017 | 0.0593 | 0.0553 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Brugia malayi | brahma associated protein 60 kDa | 0.0014 | 0.0343 | 0.0394 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0017 | 0.0593 | 0.0553 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0019 | 0.0756 | 0.1148 |
Echinococcus multilocularis | neuropeptide receptor | 0.0023 | 0.1081 | 0.128 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0025 | 0.1184 | 0.1135 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0019 | 0.0756 | 0.1148 |
Echinococcus multilocularis | aminopeptidase N | 0.0019 | 0.0756 | 0.0796 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0025 | 0.1184 | 0.1433 |
Plasmodium vivax | RNA helicase-1, putative | 0.0072 | 0.4877 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0072 | 0.4877 | 0.4695 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0015 | 0.0419 | 0.0168 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0025 | 0.1184 | 0.1276 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0014 | 0.0343 | 0.0394 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Echinococcus granulosus | neuropeptide receptor | 0.0023 | 0.1081 | 0.112 |
Loa Loa (eye worm) | aminopeptidase N | 0.0019 | 0.0756 | 0.0631 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0019 | 0.0756 | 0.0757 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0019 | 0.0756 | 0.0757 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.6934 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Chlamydia trachomatis | SWIB complex protein | 0.0014 | 0.0343 | 0.5 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0029 | 0.1532 | 0.1804 |
Trichomonas vaginalis | set domain proteins, putative | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0014 | 0.0343 | 0.0142 |
Echinococcus granulosus | geminin | 0.0098 | 0.6936 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0019 | 0.0756 | 0.0796 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0019 | 0.0756 | 0.0428 |
Onchocerca volvulus | 0.0019 | 0.0756 | 0.0428 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0593 | 0.0438 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0029 | 0.1532 | 0.1951 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.6934 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0019 | 0.0756 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K0.5 (binding) | = 10.2 nM | Displacement of [3H]-(-)-trans-H2-PAT from histamine H2 PAT binding site by competition binding assay. | ChEMBL. | 10447948 |
K0.5 (binding) | = 10.2 nM | Displacement of [3H]-(-)-trans-H2-PAT from histamine H2 PAT binding site by competition binding assay. | ChEMBL. | 10447948 |
K0.5 (binding) | = 12.7 nM | Compound was tested for the displacement of [3H]-mepyramine from Histamine H1 receptor by competition binding assay. | ChEMBL. | 10447948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.