Detailed information for compound 1697921

Basic information

Technical information
  • TDR Targets ID: 1697921
  • Name: 5-(4-aminophenyl)sulfonylpyridin-2-amine
  • MW: 249.289 | Formula: C11H11N3O2S
  • H donors: 2 H acceptors: 3 LogP: 0.62 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)S(=O)(=O)c1ccc(nc1)N
  • InChi: 1S/C11H11N3O2S/c12-8-1-3-9(4-2-8)17(15,16)10-5-6-11(13)14-7-10/h1-7H,12H2,(H2,13,14)
  • InChiKey: FHLVNQDENQBOSD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-aminophenyl)sulfonyl-2-pyridinamine
  • [4-[(6-amino-3-pyridyl)sulfonyl]phenyl]amine
  • AIDS020473
  • 4-Aminophenyl-2'-aminopyridyl-5' sulfone
  • Pyridine, 2-amino-5-sulfanilyl-
  • US2164600
  • NSC33415
  • 2-Amino-5-sulfanilylpyridine
  • AIDS-020473

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0144 0.2438 0.5946
Echinococcus granulosus cathepsin L cysteine protease 0.0113 0.1662 0.1662
Plasmodium falciparum cysteine proteinase falcipain 1 0.0113 0.1662 0.4054
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0209 0.41 0.41
Echinococcus granulosus cysteine protease 0.0113 0.1662 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0209 0.41 0.41
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0108 0.1532 0.1532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 0.3093 0.3093
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Onchocerca volvulus 0.0209 0.41 1
Toxoplasma gondii cathepsin CPL 0.0209 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0144 0.2438 0.2438
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0209 0.41 0.41
Trypanosoma cruzi cysteine proteinase, putative 0.0113 0.1662 0.1662
Onchocerca volvulus 0.0144 0.2438 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0209 0.41 1
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.41 0.41
Echinococcus multilocularis cysteine protease 0.0209 0.41 0.41
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Giardia lamblia Cathepsin B precursor 0.0169 0.3093 1
Entamoeba histolytica cysteine proteinase, putative 0.0209 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0101 0.135 0.3292
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.1662 0.4054
Schistosoma mansoni voltage-gated potassium channel 0.0118 0.1786 0.1786
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0209 0.41 0.41
Onchocerca volvulus 0.0209 0.41 1
Plasmodium vivax vivapain-1 0.0113 0.1662 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0425 0.0425
Onchocerca volvulus 0.0209 0.41 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.044 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0209 0.41 1
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.0144 0.2438 0.2438
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Loa Loa (eye worm) fibroinase 0.0209 0.41 0.41
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113 0.1662 0.1662
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0065 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0425 0.0425
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0065 0.0425 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0169 0.3093 0.7543
Brugia malayi cathepsin L-like precursor 0.0144 0.2438 0.2438
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.1662 0.4054
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0108 0.1532 0.1532
Onchocerca volvulus 0.0209 0.41 1
Echinococcus granulosus cathepsin l1 0.0144 0.2438 0.2438
Entamoeba histolytica cysteine proteinase 2 0.0113 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.41 0.41
Toxoplasma gondii cathepsin B 0.0169 0.3093 0.7543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0144 0.2438 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Echinococcus granulosus cathepsin L 0.0113 0.1662 0.1662
Giardia lamblia Cathepsin B precursor 0.0169 0.3093 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0209 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Echinococcus multilocularis cathepsin b 0.044 1 1
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Echinococcus granulosus cathepsin l cysteine peptidase 0.0209 0.41 0.41
Trypanosoma cruzi cysteine protease, putative 0.0113 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.1662 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0209 0.41 0.41
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.41 0.41
Trypanosoma brucei cysteine peptidase C (CPC) 0.0169 0.3093 0.5868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0425 0.0425
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.1662 0.1662
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Leishmania major cysteine peptidase A (CPA) 0.0209 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.0209 0.41 0.41
Trypanosoma cruzi cysteine proteinase, putative 0.0113 0.1662 0.1662
Plasmodium vivax unspecified product 0.0065 0.0425 0.1037
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0209 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Loa Loa (eye worm) hypothetical protein 0.044 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Schistosoma mansoni cathepsin F (C01 family) 0.0144 0.2438 0.2438
Brugia malayi Cathepsin L-like precursor 0.0065 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Echinococcus multilocularis cathepsin b 0.044 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0425 0.0425
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113 0.1662 0.1662
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 1 1
Plasmodium vivax unspecified product 0.0113 0.1662 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Giardia lamblia Cathepsin B precursor 0.0169 0.3093 1
Echinococcus multilocularis cathepsin L 0.0113 0.1662 0.1662
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Schistosoma mansoni cathepsin F (C01 family) 0.0209 0.41 0.41
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.41 0.41
Brugia malayi Cathepsin L-like precursor 0.0144 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0144 0.2438 0.2438
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0108 0.1532 0.1532
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.41 0.41
Loa Loa (eye worm) ctsf protein 0.0209 0.41 0.41
Plasmodium vivax vivapain-2 0.0209 0.41 1
Echinococcus multilocularis cysteine protease 0.0209 0.41 0.41
Onchocerca volvulus Cathepsin L homolog 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0144 0.2438 0.2438
Onchocerca volvulus Cathepsin L homolog 0.0209 0.41 1
Loa Loa (eye worm) cysteine protease 0.0209 0.41 0.41
Schistosoma mansoni voltage-gated potassium channel 0.0118 0.1786 0.1786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0144 0.2438 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Echinococcus granulosus cathepsin b 0.044 1 1
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0209 0.41 0.41
Onchocerca volvulus 0.0209 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Plasmodium vivax vivapain-2 0.0209 0.41 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0113 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.1662 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0209 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0113 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.044 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Loa Loa (eye worm) cathepsin B 0.0169 0.3093 0.3093
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0209 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0425 0.0425
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0101 0.135 0.3292
Loa Loa (eye worm) hypothetical protein 0.0144 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0094 0.1166 0.1166
Entamoeba histolytica cysteine proteinase, putative 0.0209 0.41 1
Plasmodium vivax vivapain-3 0.0113 0.1662 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 0.3093 0.3093
Leishmania major cathepsin L-like protease 0.0209 0.41 1
Onchocerca volvulus Cathepsin F homolog 0.0209 0.41 1
Echinococcus granulosus cathepsin b 0.044 1 1
Schistosoma mansoni cathepsin s 0.0065 0.0425 0.0425
Brugia malayi Cathepsin L-like precursor 0.0209 0.41 0.41
Echinococcus granulosus cathepsin l1 0.0209 0.41 0.41
Loa Loa (eye worm) hypothetical protein 0.0065 0.0425 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.41 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0108 0.1532 0.1532
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0209 0.41 1
Onchocerca volvulus 0.0209 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0209 0.41 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0113 0.1662 0.1662
Onchocerca volvulus 0.0209 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0144 0.2438 0.2438
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0209 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0209 0.41 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0209 0.41 1
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.1662 0.1662
Entamoeba histolytica cysteine protease, putative 0.0113 0.1662 0.4054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.