Detailed information for compound 1699589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 631.782 | Formula: C35H41N3O6S
  • H donors: 1 H acceptors: 5 LogP: 4.74 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(C)(C)C)C[C@H]1N[C@@]([C@@H]2[C@H]1C(=O)N(C2=O)Cc1ccccc1)(Cc1ccccc1)C(=O)OC
  • InChi: 1S/C35H41N3O6S/c1-6-37(45(42,43)27-19-17-26(18-20-27)34(2,3)4)23-28-29-30(32(40)38(31(29)39)22-25-15-11-8-12-16-25)35(36-28,33(41)44-5)21-24-13-9-7-10-14-24/h7-20,28-30,36H,6,21-23H2,1-5H3/t28-,29+,30-,35-/m1/s1
  • InChiKey: RUZYOOWZEOTHGY-IRYJCKHSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0037 0.0156 0.0034
Brugia malayi SRC-1 0.0031 0.0094 0.0063
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0156 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0366 0.3228 0.3208
Trypanosoma cruzi histone deacetylase, putative 0.0389 0.3445 0.5723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0156 0.0034
Brugia malayi Protein kinase domain containing protein 0.0582 0.5241 0.5226
Onchocerca volvulus 0.0045 0.0227 0.0761
Mycobacterium ulcerans two component sensor kinase MprB 0.0036 0.0146 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0148 0.0117
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0037 0.0156 0.0265
Schistosoma mansoni histone deacetylase 4 5 0.0389 0.3445 0.5829
Loa Loa (eye worm) hypothetical protein 0.0265 0.2283 0.226
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Loa Loa (eye worm) TK protein kinase 0.0281 0.2427 0.2404
Loa Loa (eye worm) histone deacetylase 11 0.0219 0.1849 0.1824
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0036 0.0146 0.5
Mycobacterium ulcerans putative regultory protein 0.0036 0.0146 0.5
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0037 0.0156 0.0018
Schistosoma mansoni sodium/solute symporter 0.0045 0.0227 0.0384
Onchocerca volvulus Slit protein homolog 0.0032 0.0102 0.005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Mycobacterium ulcerans two component regulator - sensor kinase 0.0036 0.0146 0.5
Plasmodium falciparum histone deacetylase, putative 0.0389 0.3445 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0037 0.0156 0.0031
Mycobacterium ulcerans DNA gyrase subunit B 0.0036 0.0146 0.5
Trypanosoma brucei histone deacetylase 2 0.0219 0.1849 0.2954
Trypanosoma cruzi histone deacetylase, putative 0.0219 0.1849 0.2954
Schistosoma mansoni brca1-associated protein (brap2) 0.0037 0.0156 0.0265
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0036 0.0146 0.5
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0037 0.0156 0.0031
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Loa Loa (eye worm) histone deacetylase 0.0389 0.3445 0.3426
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0156 0.0034
Brugia malayi Histone deacetylase family protein 0.0389 0.3445 0.3425
Schistosoma mansoni tyrosine kinase 0.0031 0.0094 0.0158
Loa Loa (eye worm) hypothetical protein 0.0092 0.0667 0.0638
Schistosoma mansoni pyruvate dehydrogenase 0.0617 0.557 0.9426
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0265 0.228 0.6468
Giardia lamblia Hypothetical protein 0.0037 0.0156 0.0034
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0037 0.0156 0.0031
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0156 0.0126
Schistosoma mansoni heat shock protein 0.0036 0.0146 0.0247
Trypanosoma brucei developmentally regulated phosphoprotein 0.0653 0.591 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0366 0.3228 0.5461
Echinococcus granulosus tyrosine kinase 0.0031 0.0094 0.0158
Echinococcus multilocularis histone deacetylase 1 0.0354 0.3115 0.527
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0037 0.0156 0.0018
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0036 0.0146 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0156 0.0208
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0156 0.0126
Echinococcus multilocularis protein tyrosine kinase 0.0575 0.5179 0.8762
Echinococcus multilocularis high affinity choline transporter 1 0.0408 0.3618 0.6122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0156 0.0126
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0037 0.0156 0.0126
Echinococcus multilocularis heat shock protein 90 0.0036 0.0146 0.0247
Echinococcus granulosus tyrosine protein kinase shark 0.0031 0.0094 0.0158
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0156 0.0018
Schistosoma mansoni DNA topoisomerase II 0.0036 0.0146 0.0247
Loa Loa (eye worm) hypothetical protein 0.0092 0.0667 0.0638
Echinococcus granulosus solute carrier family 5 0.0045 0.0227 0.0384
Brugia malayi EGF-like domain containing protein 0.0032 0.0102 0.0072
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0037 0.0156 0.0126
Toxoplasma gondii histone deacetylase HDAC4 0.0219 0.1849 0.5162
Schistosoma mansoni inositol transporter 0.0045 0.0227 0.0384
Echinococcus granulosus histone deacetylase 6 0.0389 0.3445 0.5829
Brugia malayi histone deacetylase 1 (HD1) 0.0354 0.3115 0.3093
Echinococcus granulosus high affinity choline transporter 1 0.0408 0.3618 0.6122
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0031 0.0094 0.0158
Schistosoma mansoni pyruvate dehydrogenase 0.0617 0.557 0.9426
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0156 0.0018
Brugia malayi Protein kinase domain containing protein 0.0031 0.0094 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0116
Leishmania major hypothetical protein, conserved 0.0037 0.0156 0.0018
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0037 0.0156 0.0126
Echinococcus granulosus tyrosine protein kinase Src64B 0.0031 0.0094 0.0158
Trypanosoma cruzi histone deacetylase 1, putative 0.0354 0.3115 0.515
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0037 0.0156 0.0265
Echinococcus granulosus sodium:glucose cotransporter 2 0.0045 0.0227 0.0384
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0653 0.591 1
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0146 0.0116
Echinococcus granulosus histone deacetylase 6 0.0427 0.3794 0.642
Brugia malayi Tyrosine-protein kinase abl-1 0.0031 0.0094 0.0063
Onchocerca volvulus 0.0097 0.0716 0.3548
Trichomonas vaginalis brca1-associated protein, putative 0.0037 0.0156 0.0034
Echinococcus multilocularis c src tyrosine kinase 0.0031 0.0094 0.0158
Echinococcus multilocularis histone deacetylase 0.0389 0.3445 0.5829
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0228 0.194 0.3113
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0036 0.0146 0.5
Plasmodium vivax histone deacetylase 1, putative 0.0354 0.3115 0.8999
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0156 0.0018
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0031 0.0094 0.0158
Plasmodium vivax histone deacetylase, putative 0.0219 0.1849 0.5162
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0045 0.0227 0.0384
Schistosoma mansoni inositol transporter 0.0045 0.0227 0.0384
Echinococcus multilocularis activated cdc42 kinase 1 0.0199 0.1665 0.2818
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0036 0.0146 0.0247
Echinococcus granulosus activated cdc42 kinase 1 0.0199 0.1665 0.2818
Brugia malayi heat shock protein 90 0.0036 0.0146 0.0116
Schistosoma mansoni brca1-associated protein (brap2) 0.0037 0.0156 0.0265
Loa Loa (eye worm) TK/ALK protein kinase 0.1091 0.9996 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0219 0.1849 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.3084 0.3064
Loa Loa (eye worm) hypothetical protein 0.0219 0.1849 0.1824
Schistosoma mansoni histone deacetylase 1 2 3 0.0219 0.1849 0.3128
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0045 0.0227 0.0384
Loa Loa (eye worm) histone deacetylase 7A 0.0389 0.3445 0.3426
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0036 0.0146 0.5
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0037 0.0156 0.0208
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0036 0.0146 0.5
Toxoplasma gondii histone deacetylase HDAC2 0.0354 0.3115 0.8999
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0036 0.0146 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0582 0.5241 0.5228
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0036 0.0146 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Echinococcus granulosus histone deacetylase 1 0.0354 0.3115 0.527
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0037 0.0156 0.0126
Trypanosoma brucei histone deacetylase 4 0.0389 0.3445 0.5723
Plasmodium vivax histone deacetylase, putative 0.0389 0.3445 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0031 0.0094 0.0158
Leishmania major histone deacetylase, putative 0.0389 0.3445 0.5723
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0037 0.0156 0.0126
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0156 0.0031
Schistosoma mansoni tyrosine kinase 0.0031 0.0094 0.0158
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0036 0.0146 0.03
Brugia malayi Histone deacetylase family protein 0.0389 0.3445 0.3425
Loa Loa (eye worm) TK protein kinase 0.0351 0.3084 0.3064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0156 0.0034
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0037 0.0156 0.0358
Schistosoma mansoni histone deacetylase 4 5 0.0389 0.3445 0.5829
Brugia malayi Probable DNA topoisomerase II 0.0036 0.0146 0.0116
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0036 0.0146 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0156 0.0034
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0653 0.591 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1665 0.164
Echinococcus granulosus MAM 0.0092 0.0667 0.1128
Schistosoma mansoni pyruvate dehydrogenase 0.0653 0.591 1
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0037 0.0156 0.0265
Loa Loa (eye worm) hypothetical protein 0.0983 0.8993 0.8993
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0031 0.0094 0.0158
Entamoeba histolytica histone deacetylase, putative 0.0354 0.3115 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0146 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0031 0.0094 0.0158
Schistosoma mansoni histone deacetylase 0.0354 0.3115 0.527
Leishmania major hypothetical protein, conserved 0.0037 0.0156 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Plasmodium falciparum histone deacetylase 2 0.0389 0.3445 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Echinococcus granulosus activated cdc42 kinase 1 0.0199 0.1665 0.2818
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0031 0.0094 0.0158
Echinococcus multilocularis histone deacetylase 7 0.0389 0.3445 0.5829
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0036 0.0146 0.0247
Loa Loa (eye worm) TOPoisomerase family member 0.0036 0.0146 0.0116
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0031 0.0094 0.0158
Echinococcus multilocularis slit 2 protein 0.0032 0.0102 0.0173
Echinococcus granulosus heat shock protein 0.0036 0.0146 0.0247
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0031 0.0094 0.0158
Echinococcus granulosus slit 2 protein 0.0032 0.0102 0.0173
Toxoplasma gondii histone deacetylase HDAC3 0.0354 0.3115 0.8999
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0228 0.194 0.3113
Schistosoma mansoni tyrosine kinase 0.0031 0.0094 0.0158
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0037 0.0156 0.0208
Schistosoma mansoni endoplasmin 0.0036 0.0146 0.0247
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0031 0.0094 0.0158
Schistosoma mansoni tyrosine kinase 0.0031 0.0094 0.0158
Loa Loa (eye worm) hypothetical protein 0.0408 0.3618 0.36
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0045 0.0227 0.0245
Onchocerca volvulus 0.0092 0.0667 0.3265
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0036 0.0146 0.5
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0228 0.194 0.3113
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0354 0.3115 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0031 0.0094 0.0158
Loa Loa (eye worm) endoplasmin 0.0036 0.0146 0.0116
Brugia malayi GH02984p 0.0408 0.3618 0.3598
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0148 0.0117
Schistosoma mansoni histone deacetylase hda2 0.0427 0.3794 0.642
Loa Loa (eye worm) hypothetical protein 0.0171 0.1403 0.1377
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0036 0.0146 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0031 0.0094 0.0158
Loa Loa (eye worm) SRC-1 0.0031 0.0094 0.0063
Brugia malayi hypothetical protein 0.0092 0.0667 0.0638
Brugia malayi Protein kinase domain containing protein 0.0031 0.0094 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0063
Brugia malayi Protein kinase domain containing protein 0.0199 0.1665 0.164
Loa Loa (eye worm) hypothetical protein 0.0071 0.0467 0.0438
Plasmodium vivax histone deacetylase 2, putative 0.0389 0.3445 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0036 0.0146 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Echinococcus granulosus tyrosine protein kinase Src42A 0.0031 0.0094 0.0158
Echinococcus granulosus histone deacetylase 7 0.0389 0.3445 0.5829
Echinococcus multilocularis histone deacetylase 3 0.0354 0.3115 0.527
Leishmania major histone deacetylase, putative 0.0389 0.3445 0.5723
Loa Loa (eye worm) hypothetical protein 0.0092 0.0667 0.0638
Echinococcus multilocularis tyrosine protein kinase Abl 0.0031 0.0094 0.0158
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0036 0.0146 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Brugia malayi Protein kinase domain containing protein 0.0031 0.0094 0.0063
Loa Loa (eye worm) hypothetical protein 0.0086 0.0611 0.0582
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0228 0.194 0.5439
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0036 0.0146 0.5
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0037 0.0156 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0031 0.0094 0.0158
Leishmania major histone deacetylase, putative 0.0354 0.3115 0.515
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Schistosoma mansoni heat shock protein 0.0036 0.0146 0.0247
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Trypanosoma cruzi histone deacetylase, putative 0.0389 0.3445 0.5723
Echinococcus granulosus tyrosine protein kinase Blk 0.0031 0.0094 0.0158
Trypanosoma brucei histone deacetylase 1 0.0354 0.3115 0.515
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Trypanosoma brucei histone deacetylase, putative 0.0389 0.3445 0.5723
Echinococcus multilocularis transfer RNA-Thr 0.0199 0.1665 0.2818
Echinococcus granulosus heat shock protein 90 0.0036 0.0146 0.0247
Schistosoma mansoni tyrosine kinase 0.0086 0.0611 0.1033
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0037 0.0156 0.0031
Brugia malayi protein-tyrosine kinase 0.0031 0.0094 0.0063
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0037 0.0156 0.0265
Echinococcus granulosus histone deacetylase 8 0.0219 0.1849 0.3128
Loa Loa (eye worm) hypothetical protein 0.0354 0.3115 0.3094
Brugia malayi Protein kinase domain containing protein 0.0031 0.0094 0.0063
Toxoplasma gondii histone deacetylase HDAC5 0.0219 0.1849 0.5162
Trypanosoma cruzi histone deacetylase 1, putative 0.0354 0.3115 0.515
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0036 0.0146 0.5
Brugia malayi histone deacetylase 11 0.0219 0.1849 0.1824
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0037 0.0156 0.0265
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Echinococcus granulosus histone deacetylase 0.0389 0.3445 0.5829
Brugia malayi Histone deacetylase 1 0.0354 0.3115 0.3093
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0036 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0351 0.3084 0.3064
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0036 0.0146 0.5
Schistosoma mansoni histone deacetylase hda2 0.0219 0.1849 0.3128
Schistosoma mansoni tyrosine kinase 0.0031 0.0094 0.0158
Leishmania major developmentally regulated phosphoprotein-like protein 0.0653 0.591 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0031 0.0094 0.0158
Echinococcus multilocularis MAM 0.0092 0.0667 0.1128
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0086 0.0611 0.1033
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Brugia malayi SH2 domain containing protein 0.0366 0.3228 0.3207
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0036 0.0146 0.5
Brugia malayi kinase, mitochondrial precursor 0.0653 0.591 0.5897
Echinococcus granulosus sodium:glucose cotransporter 0.0045 0.0227 0.0384
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0354 0.3115 1
Echinococcus multilocularis heat shock protein 0.0036 0.0146 0.0247
Mycobacterium leprae Probable two-component sensor kinase 0.0036 0.0146 0.5
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0036 0.0146 0.5
Brugia malayi SH2 domain containing protein 0.0031 0.0094 0.0063
Echinococcus multilocularis solute carrier family 5 0.0045 0.0227 0.0384
Onchocerca volvulus 0.0031 0.0099 0.0033
Echinococcus granulosus c src tyrosine kinase 0.0031 0.0094 0.0158
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0036 0.0146 0.5
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0036 0.0146 0.5
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0045 0.0227 0.0384
Schistosoma mansoni tyrosine kinase 0.0032 0.011 0.0186
Echinococcus multilocularis protein KINase family member (kin 25) 0.0086 0.0611 0.1033
Brugia malayi BRCA1-associated protein 2 containing protein 0.0037 0.0156 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0072
Brugia malayi hypothetical protein 0.0031 0.0094 0.0063
Echinococcus multilocularis tyrosine protein kinase shark 0.0031 0.0094 0.0158
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0156 0.0018
Plasmodium falciparum histone deacetylase 1 0.0354 0.3115 0.8999
Echinococcus multilocularis BRCA1 associated protein 0.0037 0.0156 0.0265
Trypanosoma cruzi histone deacetylase, putative 0.0219 0.1849 0.2954
Brugia malayi Endoplasmin precursor 0.0036 0.0146 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0156 0.0031
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0037 0.0156 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0094 0.0063
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0653 0.591 1
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0146 0.0174
Echinococcus granulosus tyrosine kinase 0.0031 0.0094 0.0158
Mycobacterium leprae Probable two component sensor kinase MprB 0.0036 0.0146 0.5
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0037 0.0156 0.0031
Loa Loa (eye worm) hypothetical protein 0.0208 0.1752 0.1727
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0116
Toxoplasma gondii histone deacetylase HDAC1 0.0389 0.3445 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0197
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0037 0.0156 0.0018
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0036 0.0146 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0031 0.0094 0.0158
Schistosoma mansoni endoplasmin 0.0036 0.0146 0.0247
Echinococcus multilocularis histone deacetylase 6 0.0427 0.3794 0.642
Brugia malayi Sodium:solute symporter family protein 0.0045 0.0227 0.0197
Schistosoma mansoni hypothetical protein 0.0092 0.0667 0.1128
Echinococcus granulosus tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Leishmania major histone deacetylase, putative 0.0354 0.3115 0.515
Loa Loa (eye worm) histone deacetylase 1 0.0354 0.3115 0.3094
Mycobacterium tuberculosis Probable two component sensor kinase 0.0036 0.0146 0.5
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0037 0.0156 0.0265
Brugia malayi histone deacetylase 3 (HD3) 0.0354 0.3115 0.3093
Echinococcus granulosus histone deacetylase 3 0.0354 0.3115 0.527
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0037 0.0156 0.0031
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0036 0.0146 0.0116
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0037 0.0156 0.0265
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0045 0.0227 0.0384
Schistosoma mansoni hypothetical protein 0.0092 0.0667 0.1128
Echinococcus granulosus sodium:myo inositol cotransporter 0.0045 0.0227 0.0384
Brugia malayi Protein kinase domain containing protein 0.0281 0.2427 0.2404
Echinococcus granulosus BRCA1 associated protein 0.0037 0.0156 0.0265
Echinococcus multilocularis histone deacetylase 6 0.0389 0.3445 0.5829
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0036 0.0146 0.03
Echinococcus multilocularis tyrosine protein kinase 0.0281 0.2427 0.4106
Echinococcus multilocularis histone deacetylase 6 0.0389 0.3445 0.5829
Echinococcus multilocularis tyrosine kinase 0.0031 0.0094 0.0158
Echinococcus granulosus tyrosine protein kinase 0.0281 0.2427 0.4106
Giardia lamblia Histone deacetylase 0.0354 0.3115 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0031 0.0094 0.0063
Schistosoma mansoni high-affinity choline transporter 0.0408 0.3618 0.6122
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0036 0.0146 0.03
Trichomonas vaginalis BRCA1-associated protein, putative 0.0037 0.0156 0.0034
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0036 0.0146 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0031 0.0094 0.0158
Trypanosoma brucei histone deacetylase 3 0.0389 0.3445 0.5723
Trichomonas vaginalis histone deacetylase, putative 0.0354 0.3115 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0031 0.0094 0.0158
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0036 0.0146 0.5
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0036 0.0146 0.0116
Echinococcus multilocularis tyrosine protein kinase Blk 0.0031 0.0094 0.0158
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0146 0.5
Echinococcus granulosus protein tyrosine kinase 0.0575 0.5179 0.8762
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0653 0.591 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.1522 0.1496
Entamoeba histolytica DNA topoisomerase II, putative 0.0036 0.0146 0.0174
Echinococcus granulosus tyrosine protein kinase Fyn 0.0031 0.0094 0.0158
Brugia malayi Protein kinase domain containing protein 0.0031 0.0094 0.0063
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0036 0.0146 0.5
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0146 0.0174
Trypanosoma cruzi histone deacetylase, putative 0.0389 0.3445 0.5723
Echinococcus multilocularis histone deacetylase 8 0.0219 0.1849 0.3128
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0037 0.0156 0.0031
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0354 0.3115 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0036 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0653 0.591 0.5899
Schistosoma mansoni tyrosine kinase 0.0575 0.5179 0.8762
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0366 0.3228 0.5461
Schistosoma mansoni histone deacetylase 0.0354 0.3115 0.527
Mycobacterium tuberculosis Possible two component sensor kinase 0.0036 0.0146 0.5
Echinococcus granulosus histone deacetylase 6 0.0389 0.3445 0.5829
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0146 0.5
Loa Loa (eye worm) TK protein kinase 0.0031 0.0094 0.0063
Loa Loa (eye worm) histone deacetylase 3 0.0354 0.3115 0.3094
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0037 0.0156 0.0265
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0036 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0467 0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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