Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0833 | 0.8048 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0179 | 0.0757 | 1 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0227 | 0.1022 | 1 |
Onchocerca volvulus | 0.005 | 0.0057 | 0.056 | |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.0833 | 0.0781 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.0833 | 0.8048 |
Trypanosoma brucei | hypothetical protein, conserved | 0.005 | 0.0057 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0057 | 0.5 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0057 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0833 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.0833 | 0.0781 |
Onchocerca volvulus | 0.0227 | 0.1022 | 1 | |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0057 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0227 | 0.1022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Brugia malayi | folate-like transporter 3 | 0.0227 | 0.1022 | 1 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0057 | 0.5 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0227 | 0.1022 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0057 | 0.5 |
Onchocerca volvulus | 0.0227 | 0.1022 | 1 | |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0227 | 0.1022 | 1 |
Onchocerca volvulus | 0.0227 | 0.1022 | 1 | |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0039 | 0 | 0.5 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.0833 | 0.8048 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0179 | 0.0757 | 1 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0675 | 0.3455 | 0.3417 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0675 | 0.345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0833 | 0.8048 |
Echinococcus multilocularis | folate receptor beta | 0.188 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.0833 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.0833 | 0.8048 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0675 | 0.3455 | 0.3417 |
Entamoeba histolytica | hypothetical protein | 0.0227 | 0.1022 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.0833 | 0.2287 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0057 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.0562 | 0.65 |
Brugia malayi | Reduced folate carrier family protein | 0.0227 | 0.1022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0179 | 0.0757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.0562 | 0.2252 |
Toxoplasma gondii | hypothetical protein | 0.0462 | 0.2297 | 1 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.0833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1022 | 1 |
Giardia lamblia | Hypothetical protein | 0.0227 | 0.1022 | 1 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0057 | 0.5 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0057 | 0.5 |
Onchocerca volvulus | 0.0227 | 0.1022 | 1 | |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.0833 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.