Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hypothetical protein | 0.0702 | 0.7344 | 1 |
Brugia malayi | Serotonin receptor | 0.047 | 0.4769 | 0.4915 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0914 | 0.9703 | 1 |
Plasmodium falciparum | transporter, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.2247 | 0.2247 |
Plasmodium falciparum | amino acid transporter, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0243 | 0.2247 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0243 | 0.2247 | 0.3059 |
Onchocerca volvulus | 0.0243 | 0.2247 | 0.2247 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0243 | 0.2247 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0243 | 0.2247 | 0.2247 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0243 | 0.2247 | 0.2316 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0243 | 0.2247 | 0.3093 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.2247 | 0.2247 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0243 | 0.2247 | 0.2247 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0694 | 0.7264 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0243 | 0.2247 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0041 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.9703 | 0.9703 |
Loa Loa (eye worm) | serotonin transporter b | 0.0243 | 0.2247 | 0.2247 |
Onchocerca volvulus | CoRest homolog | 0.094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.