Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0756 | 1 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0043 | 0.0016 | 0.5 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0016 | 0.0073 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0016 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0043 | 0.0016 | 1 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0016 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0756 | 1 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0756 | 1 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0043 | 0.0016 | 0.0073 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0016 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.2195 | 0.2195 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0016 | 0.0066 |
Echinococcus multilocularis | geminin | 0.0199 | 0.2195 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0043 | 0.0016 | 0.0016 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0043 | 0.0016 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0016 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.0756 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0756 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0756 | 1 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0216 | 0.2434 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.2195 | 0.2195 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.3191 | 0.3191 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0043 | 0.0016 | 0.0016 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0016 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0043 | 0.0016 | 0.0073 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0016 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0016 | 0.0073 |
Echinococcus granulosus | geminin | 0.0199 | 0.2195 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0016 | 0.0073 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0016 | 0.0073 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0043 | 0.0016 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.