Detailed information for compound 1714059

Basic information

Technical information
  • TDR Targets ID: 1714059
  • Name: 1-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)p yrrolidin-2-one
  • MW: 340.395 | Formula: C15H20N2O5S
  • H donors: 0 H acceptors: 3 LogP: 0.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)N1CCOCC1)N1CCCC1=O
  • InChi: 1S/C15H20N2O5S/c1-21-13-5-4-12(17-6-2-3-15(17)18)11-14(13)23(19,20)16-7-9-22-10-8-16/h4-5,11H,2-3,6-10H2,1H3
  • InChiKey: HBISTGSIJBUEIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methoxy-3-morpholinosulfonyl-phenyl)pyrrolidin-2-one
  • 1-(4-methoxy-3-morpholinosulfonylphenyl)-2-pyrrolidinone
  • 1-(4-methoxy-3-morpholinosulfonyl-phenyl)-2-pyrrolidone
  • 1-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)pyrrolidin-2-one
  • ZINC06938432
  • T5371654

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1804 0.315
Brugia malayi 6-phosphofructokinase 0.011 0.3906 0.6821
Leishmania major ATP-dependent phosphofructokinase 0.011 0.3906 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.3358 0.5865
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3906 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.3358 0.5865
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0638 0.1114
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0408 0.5
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0154 0.6081 0.5979
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0587 0.0862
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0254 0.0444
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.5726 1
Brugia malayi phosphofructokinase 0.011 0.3906 0.6821
Loa Loa (eye worm) beta-lactamase 0.0036 0.0254 0.0444
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1482 0.2177
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.3906 0.6821
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0154 0.6081 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0154 0.6081 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.5522 0.8114
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1482 0.2177
Brugia malayi 6-phosphofructokinase 0.011 0.3906 0.6821
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3906 0.6266
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1482 0.2177
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.3906 1
Schistosoma mansoni 6-phosphofructokinase 0.011 0.3906 0.5739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0638 0.0937
Schistosoma mansoni hypothetical protein 0.0169 0.6806 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0638 0.0937
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1482 0.2177
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0587 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0408 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0638 0.0937
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.3906 0.3747
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.3358 0.5865
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0154 0.6081 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0638 0.0937
Echinococcus multilocularis geminin 0.0169 0.6806 1
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.3906 0.5739
Echinococcus granulosus geminin 0.0169 0.6806 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Loa Loa (eye worm) RNA binding protein 0.0061 0.1482 0.2587
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0638 0.0937
Loa Loa (eye worm) hypothetical protein 0.0068 0.1804 0.315
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0254 0.0373
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.5726 0.8414
Brugia malayi RNA binding protein 0.0061 0.1482 0.2587
Mycobacterium ulcerans hypothetical protein 0.0154 0.6081 1
Brugia malayi beta-lactamase family protein 0.0036 0.0254 0.0444
Loa Loa (eye worm) hypothetical protein 0.0099 0.3358 0.5865
Echinococcus granulosus 6 phosphofructokinase 0.011 0.3906 0.5739
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.3906 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0638 0.1114
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1482 0.2587
Onchocerca volvulus 0.0036 0.0254 0.5
Schistosoma mansoni hypothetical protein 0.0169 0.6806 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0587 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0587 0.0571
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.3906 0.5
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.3906 0.6266
Brugia malayi TAR-binding protein 0.0061 0.1482 0.2587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0638 0.0937
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1482 0.2587
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1482 0.2587
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3906 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0254 0.0373
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3906 0.6266
Loa Loa (eye worm) phosphofructokinase 0.011 0.3906 0.6821
Onchocerca volvulus 0.0036 0.0254 0.5
Brugia malayi beta-lactamase family protein 0.0036 0.0254 0.0444
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0587 0.0571
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.3906 0.6266
Schistosoma mansoni hypothetical protein 0.0068 0.1804 0.2651
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0254 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0254 0.0373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3906 0.6266
Onchocerca volvulus 0.0036 0.0254 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0444
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.3906 0.6821
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0638 0.0937
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1482 0.2177
Loa Loa (eye worm) acetyltransferase 0.0147 0.5726 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.5726 0.8414
Schistosoma mansoni 6-phosphofructokinase 0.011 0.3906 0.5739
Entamoeba histolytica phosphofructokinase, putative 0.011 0.3906 1
Brugia malayi beta-lactamase 0.0036 0.0254 0.0444
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1482 0.2177
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0254 0.0444
Mycobacterium tuberculosis Probable aminotransferase 0.0154 0.6081 0.5979
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.3906 0.6266
Echinococcus granulosus tar DNA binding protein 0.0061 0.1482 0.2177

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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