Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus anthracis | Replicative DNA helicase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Schistosoma mansoni | Replicative DNA helicase | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Treponema pallidum | replicative DNA helicase (dnaB) | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Chlamydia trachomatis | replicative DNA helicase | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | Get druggable targets OG5_131890 | All targets in OG5_131890 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0289 | 0.3231 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0778 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0778 | 1 | 0.5 |
Schistosoma mansoni | Replicative DNA helicase | 0.0778 | 1 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.0206 | 0.5 | |
Leishmania major | stearic acid desaturase, putative | 0.0071 | 0.0206 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.0206 | 0.5 | |
Loa Loa (eye worm) | twinkle helicase | 0.0222 | 0.2299 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0056 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0056 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0056 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0778 | 1 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0289 | 0.3231 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0071 | 0.0206 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0071 | 0.0206 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0071 | 0.0206 | 0.5 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0778 | 1 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0778 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 4.4 uM | Cytotoxicity against human HeLa cells by MTS assay | ChEMBL. | 23231076 |
IC50 (binding) | = 10.2 uM | Inhibition of Bacillus anthracis Sterne 34F2 replicative DNA helicase-mediated ATP-dependent dissociation of Hel-5'FAM:Hel-3'BHQ by FRET assay | ChEMBL. | 23231076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.