Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Mus musculus | fibroblast activation protein | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.3882 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1647 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.2526 | 0.632 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.3882 | 0.3759 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.2526 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.3882 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.3882 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0198 | 0.0784 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.023 uM | Inhibition of pig PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide substrate | ChEMBL. | 23121075 |
IC50 (binding) | > 5 uM | Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
IC50 (binding) | > 10 uM | Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 23121075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.