Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1518 | 0.9903 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1518 | 0.9903 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.054 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1518 | 0.9903 | 0.9903 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.054 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1518 | 0.9903 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.054 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1518 | 0.9903 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.054 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.054 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1518 | 0.9903 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1518 | 0.9903 | 0.9903 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1518 | 0.9903 | 1 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1518 | 0.9903 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1518 | 0.9903 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.054 | 0 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1518 | 0.9903 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1518 | 0.9903 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.1518 | 0.9903 | 0.9903 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1518 | 0.9903 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1518 | 0.9903 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.054 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.054 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.054 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1518 | 0.9903 | 1 |
Onchocerca volvulus | 0.1518 | 0.9903 | 1 | |
Loa Loa (eye worm) | brahma associated protein | 0.1518 | 0.9903 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1518 | 0.9903 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.1518 | 0.9903 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1518 | 0.9903 | 1 |
Leishmania major | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1518 | 0.9903 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1518 | 0.9903 | 0.9903 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1518 | 0.9903 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1518 | 0.9903 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.054 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log Ki (binding) | = -0.84 | Inhibitory activity was determined against HIV type 1 protease | ChEMBL. | 8523405 |
IC50 (functional) | = 1340 nM | Antiviral activity by observing cytopathic effect induced by HIV-1 strain IIIB in de novo infected MT-4 cells | ChEMBL. | 7932531 |
Ki (binding) | = -0.84 | Inhibitory activity was determined against HIV type 1 protease | ChEMBL. | 8523405 |
Ki (binding) | = 6.9 nM | Inhibitory constant against HIV-1 protease | ChEMBL. | 7932531 |
Ki (binding) | = 6.9 nM | Inhibitory constant against HIV-1 protease | ChEMBL. | 7932531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.