Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.4932 | 0.3791 | 1 |
Echinococcus multilocularis | nicalin | 0.0883 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.0386 | 0.0386 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0728 | 0.0463 | 0.0463 |
Echinococcus granulosus | Nicastrin | 0.2404 | 0.1789 | 0.1789 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0211 | 0.0053 | 0.0053 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.2773 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1727 | 0.1253 | 0.1253 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.2773 | 1 | 1 |
Echinococcus granulosus | presenilin | 0.4932 | 0.3791 | 0.3791 |
Brugia malayi | hypothetical protein | 0.2404 | 0.1789 | 0.1789 |
Echinococcus multilocularis | Nicastrin | 0.2404 | 0.1789 | 0.1789 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.1727 | 0.1253 | 0.1253 |
Trypanosoma brucei | Aph-1 protein, putative | 0.4977 | 0.3827 | 1 |
Brugia malayi | Presenilin spe-4 | 0.1727 | 0.1253 | 0.1253 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0795 | 0.0516 | 0.0516 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Echinococcus granulosus | nicalin | 0.0883 | 0.0585 | 0.0585 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4977 | 0.3827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2404 | 0.1789 | 0.1789 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0211 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0053 | 0.0053 |
Brugia malayi | hypothetical protein | 0.2404 | 0.1789 | 0.1789 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.4932 | 0.3791 | 0.9889 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4932 | 0.3791 | 1 |
Schistosoma mansoni | hypothetical protein | 0.2404 | 0.1789 | 0.1789 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.4629 | 0.3551 | 0.3551 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.2404 | 0.1789 | 0.472 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1727 | 0.1253 | 0.1253 |
Echinococcus granulosus | presenilin enhancer 2 | 0.4629 | 0.3551 | 0.3551 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0211 | 0.0053 | 0.0053 |
Brugia malayi | Presenilin spe-4 | 0.1727 | 0.1253 | 0.1253 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.4932 | 0.3791 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0249 | 0.0083 | 0.0083 |
Brugia malayi | Presenilin family protein | 0.4932 | 0.3791 | 0.3791 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4932 | 0.3791 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.4932 | 0.3791 | 0.9889 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.2404 | 0.1789 | 0.472 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.2773 | 1 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.4629 | 0.3551 | 0.3551 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0211 | 0.0053 | 0.0053 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0728 | 0.0463 | 0.0463 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4932 | 0.3791 | 1 |
Brugia malayi | Presenilin spe-4 | 0.1727 | 0.1253 | 0.1253 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0728 | 0.0463 | 0.0463 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.4932 | 0.3791 | 0.9889 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0728 | 0.0463 | 0.0463 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0795 | 0.0516 | 0.0516 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.4932 | 0.3791 | 0.3791 |
Echinococcus multilocularis | Nicastrin | 0.2404 | 0.1789 | 0.1789 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.1393 | 0.0989 | 0.1245 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.068 | 0.0425 | 0.112 |
Echinococcus granulosus | voltage gated potassium channel | 0.0211 | 0.0053 | 0.0053 |
Toxoplasma gondii | hypothetical protein | 0.1727 | 0.1253 | 1 |
Brugia malayi | hypothetical protein | 0.1727 | 0.1253 | 0.1253 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4977 | 0.3827 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0249 | 0.0083 | 0.0083 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0211 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.2773 | 1 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.4629 | 0.3551 | 0.3551 |
Brugia malayi | hypothetical protein | 0.1727 | 0.1253 | 0.1253 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Echinococcus multilocularis | presenilin | 0.4932 | 0.3791 | 0.3791 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.068 | 0.0425 | 0.112 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0249 | 0.0083 | 0.0083 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0211 | 0.0053 | 0.0053 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.29 uM | Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincubated for 30 mins before ATP treatment by Fluo-4 AM fluorescence method | ChEMBL. | 23075067 |
Inhibition (functional) | = 27 % | Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated at IC50 for 30 mins before ATP treatment by Fluo-4 AM fluorescence method | ChEMBL. | 23075067 |
Inhibition (functional) | = 51 % | Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated at 100 uM for 30 mins before ATP treatment by Fluo-4 AM fluorescence method | ChEMBL. | 23075067 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.