Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0031 | 0.0011 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0162 | 0.2513 | 0.2545 |
Schistosoma mansoni | protein kinase | 0.0031 | 0.0011 | 0.0011 |
Entamoeba histolytica | protein kinase, putative | 0.0031 | 0.0011 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0052 | 0.0409 | 0.0414 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0192 | 0.3089 | 0.3089 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0052 | 0.0409 | 0.0414 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.5064 | 0.5064 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0548 | 0.9876 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0548 | 0.9876 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.5064 | 0.5127 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0555 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0162 | 0.2513 | 0.2545 |
Entamoeba histolytica | protein kinase, putative | 0.0052 | 0.0409 | 1 |
Echinococcus granulosus | protein tyrosine kinase | 0.0548 | 0.9876 | 1 |
Brugia malayi | Protein kinase domain | 0.0052 | 0.0409 | 0.0409 |
Trichomonas vaginalis | STE family protein kinase | 0.0052 | 0.0409 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.5064 | 0.5064 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0052 | 0.0409 | 0.0414 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.1622 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0398 | 0.0398 |
Schistosoma mansoni | protein kinase | 0.0052 | 0.0409 | 0.0414 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0052 | 0.0409 | 0.0414 |
Entamoeba histolytica | protein kinase, putative | 0.0031 | 0.0011 | 0.0277 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0052 | 0.0409 | 0.0414 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.5064 | 0.5127 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0031 | 0.0011 | 0.0011 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.1622 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0032 | 0.0044 | 0.0044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0398 | 0.9715 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0.0044 | 0.0044 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0052 | 0.0409 | 0.0414 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.5064 | 0.5127 |
Entamoeba histolytica | p21-activated kinase | 0.0052 | 0.0409 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.1622 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0052 | 0.0409 | 0.0414 |
Trichomonas vaginalis | STE family protein kinase | 0.0052 | 0.0409 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0052 | 0.0409 | 0.5 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0192 | 0.3089 | 0.3089 |
Trichomonas vaginalis | STE family protein kinase | 0.0052 | 0.0409 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0052 | 0.0409 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13300 nM | Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassay | ChEMBL. | 24900409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.