Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | methionine-tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0043 | 0.4732 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0027 | 0.2647 | 0.2647 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0017 | 0.1354 | 0.5 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0017 | 0.1354 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0017 | 0.1354 | 0.5 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0017 | 0.1354 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0017 | 0.1354 | 0.2862 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1354 | 0.1354 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0043 | 0.4732 | 0.5 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0043 | 0.4732 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 0.4732 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0043 | 0.4732 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0043 | 0.4732 | 0.5 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0043 | 0.4732 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0017 | 0.1354 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0017 | 0.1354 | 0.2862 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Brugia malayi | methionyl-tRNA synthetase | 0.0017 | 0.1354 | 0.1354 |
Brugia malayi | protein ZK524.3 | 0.0017 | 0.1354 | 0.1354 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0043 | 0.4732 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0043 | 0.4732 | 1 |
Onchocerca volvulus | 0.0027 | 0.2647 | 0.5 | |
Brugia malayi | methionyl-tRNA synthetase | 0.0043 | 0.4732 | 0.4732 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0017 | 0.1354 | 0.2862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 80 % | Inhibition of Class 1 histone deacetylase in human HeLa cells assessed as induction in p21 protein expression at 3 uM incubated for 16 hrs by luciferase reporter gene assay relative to HDAC inhibitor entinostat | ChEMBL. | 23061376 |
CL (ADMET) | = 41 ml/min.kg | Clearance in mouse liver microsomes at 1 uM incubated for 10 mins by LC-MS/MS method | ChEMBL. | 23061376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.