Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0092 | 0.0445 | 0.2487 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0585 | 0.9181 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0167 | 0.1789 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0167 | 0.1789 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0585 | 0.9181 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0167 | 0.1789 | 0.1407 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0092 | 0.0445 | 0.2487 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0167 | 0.1789 | 0.5 |
Leishmania major | protein kinase, putative | 0.0167 | 0.1789 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0167 | 0.1789 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0158 | 0.1623 | 0.9072 |
Trichomonas vaginalis | STE family protein kinase | 0.0158 | 0.1623 | 0.9072 |
Schistosoma mansoni | protein kinase | 0.0092 | 0.0445 | 0.2487 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 0.1789 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0167 | 0.1789 | 0.1407 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0493 | 0.7558 | 0.7444 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0493 | 0.7558 | 0.7444 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0167 | 0.1789 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0167 | 0.1789 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0158 | 0.1623 | 0.1233 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 0.1789 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1567 | 0.8759 |
Trichomonas vaginalis | STE family protein kinase | 0.0158 | 0.1623 | 0.9072 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0092 | 0.0445 | 0.0485 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0445 | 0.2487 |
Loa Loa (eye worm) | AUR protein kinase | 0.0167 | 0.1789 | 0.1949 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0158 | 0.1623 | 0.1233 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.0501 | 0.0416 |
Toxoplasma gondii | aurora kinase | 0.0167 | 0.1789 | 0.5 |
Brugia malayi | Protein kinase domain | 0.0158 | 0.1623 | 0.1768 |
Entamoeba histolytica | protein kinase, putative | 0.0167 | 0.1789 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0167 | 0.1789 | 0.1949 |
Schistosoma mansoni | protein kinase | 0.0095 | 0.0501 | 0.28 |
Loa Loa (eye worm) | AUR protein kinase | 0.0167 | 0.1789 | 0.1949 |
Entamoeba histolytica | protein kinase, putative | 0.0167 | 0.1789 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 0.1789 | 1 |
Schistosoma mansoni | protein kinase | 0.0158 | 0.1623 | 0.9072 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0167 | 0.1789 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0092 | 0.0445 | 0.0485 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0167 | 0.1789 | 0.1949 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0158 | 0.1623 | 0.1233 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0095 | 0.0501 | 0.0059 |
Trichomonas vaginalis | STE family protein kinase | 0.0158 | 0.1623 | 0.9072 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0167 | 0.1789 | 1 |
Brugia malayi | WH1 domain containing protein | 0.0092 | 0.0445 | 0.0485 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0158 | 0.1623 | 0.1233 |
Echinococcus granulosus | aurora kinase A | 0.0167 | 0.1789 | 0.1407 |
Loa Loa (eye worm) | AUR protein kinase | 0.0167 | 0.1789 | 0.1949 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0445 | 0.2487 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0167 | 0.1789 | 0.1407 |
Schistosoma mansoni | protein kinase | 0.0167 | 0.1789 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0158 | 0.1623 | 0.1233 |
Trichomonas vaginalis | STE family protein kinase | 0.0095 | 0.0501 | 0.28 |
Trichomonas vaginalis | AGC family protein kinase | 0.0167 | 0.1789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1567 | 0.1707 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.0501 | 0.0416 |
Entamoeba histolytica | p21-activated kinase | 0.0158 | 0.1623 | 0.8764 |
Entamoeba histolytica | protein kinase, putative | 0.0158 | 0.1623 | 0.8764 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0445 | 0.2487 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0445 | 0.2487 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.0501 | 0.0416 |
Trichomonas vaginalis | STE family protein kinase | 0.0158 | 0.1623 | 0.9072 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.1789 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0158 | 0.1623 | 0.1233 |
Giardia lamblia | Aurora kinase | 0.0167 | 0.1789 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0092 | 0.0445 | 0.0485 |
Brugia malayi | serine/threonine kinase 12 | 0.0167 | 0.1789 | 0.1949 |
Entamoeba histolytica | protein kinase , putative | 0.0167 | 0.1789 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Agonist activity at MOP receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins | ChEMBL. | 23022277 | |
Ki (binding) | = 132 nM | Displacement of [3H]DAMGO from MOP receptor expressed in CHO-K1 cells after overnight incubation by beta counting method | ChEMBL. | 23022277 |
Ki (binding) | = 2254 nM | Displacement of [3H]DPDPE from DOP receptor expressed in CHO-K1 cells after overnight incubation by beta counting method | ChEMBL. | 23022277 |
Papp (ADMET) | = 8.08 ucm/s | Apparent permeability across human Caco2 cells st 200 uM measured over 150 mins by LC/MS analysis | ChEMBL. | 23022277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.