Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.2194 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2654 | 0.0313 | 0.0313 |
Schistosoma mansoni | serine/threonine kinase | 0.7963 | 0.5704 | 0.5704 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2654 | 0.0313 | 0.0313 |
Echinococcus granulosus | calcium activated potassium channel | 0.2654 | 0.0313 | 0.0313 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8293 | 0.6039 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8293 | 0.6039 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.2634 | 0.0292 | 0.0292 |
Schistosoma mansoni | hypothetical protein | 0.2634 | 0.0292 | 0.0292 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.5329 | 0.3028 | 0.3028 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2654 | 0.0313 | 0.0313 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2654 | 0.0313 | 0.0313 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8293 | 0.6039 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.7963 | 0.5704 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.2194 | 1 | 0.5 |
Brugia malayi | Kinase associated domain 1 family protein | 0.2634 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.7963 | 0.5704 | 0.5704 |
Schistosoma mansoni | hypothetical protein | 0.2634 | 0.0292 | 0.0292 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2654 | 0.0313 | 0.0313 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8293 | 0.6039 | 0.5 |
Onchocerca volvulus | 0.2347 | 0 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 1.2194 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2654 | 0.0313 | 0.0313 |
Echinococcus multilocularis | calcium activated potassium channel | 0.2654 | 0.0313 | 0.0313 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.5329 | 0.3028 | 0.3028 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2654 | 0.0313 | 0.0313 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2654 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.2634 | 0.0292 | 0.0292 |
Brugia malayi | Dihydrofolate reductase | 1.2194 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.2194 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.2194 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.2194 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.2194 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.2194 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.8293 | 0.6039 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8293 | 0.6039 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2654 | 0.0313 | 0.0313 |
Brugia malayi | Protein kinase domain containing protein | 0.7963 | 0.5704 | 0.5704 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 5 nM | Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 95 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 95 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 166 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 166 nM | Binding affinity towards human dopamine D2 receptor, using [3H]-YM-09151 as a radioligand | ChEMBL. | 12372512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.