Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0204 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0141 | 0.1296 | 0.1296 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0204 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0204 | 0.5571 | 0.5571 |
Echinococcus granulosus | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0146 | 0.1672 | 0.1672 |
Trypanosoma brucei | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0204 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0204 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 2 | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0204 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Schistosoma mansoni | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0204 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0146 | 0.1672 | 0.1672 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0204 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0141 | 0.1296 | 0.1296 |
Echinococcus multilocularis | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0204 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha-2 chain | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0204 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0204 | 0.5571 | 0.5571 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0141 | 0.1296 | 0.1296 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0146 | 0.1672 | 0.1672 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1296 | 0.1296 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0146 | 0.1672 | 0.1672 |
Schistosoma mansoni | tubulin subunit alpha | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0204 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0204 | 0.5571 | 0.4682 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0204 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0141 | 0.1296 | 0.1296 |
Trypanosoma brucei | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0204 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0204 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0204 | 0.5571 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.0204 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0204 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0204 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of VDR-RXRalpha heterodimerization in human HCT116 cells assessed as Renilla luciferase reporter gene transcriptional activity at 20 to 40 uM after 24 hrs by mammalian two-hybrid assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at glucocorticoid receptor (unknown origin) expressed in human HCT116 cells co-expressing GRE at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at human VDR expressed in human HCT116 cells assessed as CYP24A1 transcriptional activity at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at RXR (unknown origin) expressed in human HCT116 cells co-expressing RXRE at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at human VDR expressed in human HCT116 cells co-expressing VDRE assessed as XDR3 transcriptional activity at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at human VDR expressed in human HCT116 cells assessed as induction of recruitment of DRIP205 at 20 to 40 uM after 24 hrs by mammalian two hybrid system based luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at RAR (unknown origin) expressed in human HCT116 cells co-expressing RARE at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Agonist activity at human VDR expressed in human HCT116 cells assessed as induction of recruitment of SRC-1 at 20 to 40 uM after 24 hrs by mammalian two hybrid system based luciferase reporter gene assay | ChEMBL. | 23276449 | |
Activity (binding) | Induction of RXRalpha-AD/RXRalpha-BD (unknown origin) homodimerization expressed in human HCT116 cells at 20 to 40 uM after 24 hrs by luciferase reporter gene assay | ChEMBL. | 23276449 | |
FC (binding) | = 8 | Agonist activity at human VDR expressed in human HCT116 cells co-expressing VDRE assessed as XDR3 transcriptional activity at 20 to 40 uM after 24 hrs by luciferase reporter gene assay relative to control in presence of resveratrol | ChEMBL. | 23276449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.