Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0048 | 0.2795 | 0.5 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0023 | 0.0366 | 0.1449 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.7205 | 0.7099 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0044 | 0.2458 | 0.9637 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Brugia malayi | calcium ATPase | 0.0023 | 0.0366 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2524 | 0.224 |
Loa Loa (eye worm) | calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0028 | 0.0852 | 0.0504 |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0028 | 0.0918 | 0.5 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0045 | 0.2524 | 1 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0044 | 0.2458 | 0.2248 |
Brugia malayi | haloacid dehalogenase-like hydrolase family protein | 0.0025 | 0.0608 | 0.0347 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0106 | 0.8394 | 0.8333 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0045 | 0.2524 | 0.0092 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0045 | 0.2524 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5384 | 0.5208 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.012 | 0.9729 | 1 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0025 | 0.0637 | 0.1219 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8897 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0119 | 0.9663 | 0.9553 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0044 | 0.2458 | 0.8612 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8897 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0852 | 0.0504 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0119 | 0.9663 | 1 |
Leishmania major | calcium-translocating P-type ATPase | 0.0045 | 0.2524 | 1 |
Plasmodium vivax | P-type ATPase4, putative | 0.0048 | 0.2795 | 0.5 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0045 | 0.2524 | 1 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0044 | 0.2458 | 0.9637 |
Toxoplasma gondii | P-type ATPase PMA1 | 0.0026 | 0.0703 | 0.1388 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0048 | 0.2795 | 0.0468 |
Trypanosoma cruzi | plasma-membrane proton-efflux P-type ATPase, putative | 0.0023 | 0.0366 | 0.1449 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0045 | 0.2524 | 0.8884 |
Leishmania major | calcium-transporting ATPase, putative | 0.0044 | 0.2458 | 0.9637 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0023 | 0.0366 | 0.1449 |
Trypanosoma brucei | calcium-transporting ATPase, putative | 0.0028 | 0.0852 | 0.0818 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha-3 chain, putative | 0.0023 | 0.0366 | 0.0097 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0044 | 0.2458 | 0.2248 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0119 | 0.9663 | 1 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0044 | 0.2458 | 0.9637 |
Onchocerca volvulus | 0.012 | 0.9729 | 0.5 | |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0048 | 0.2795 | 0.0468 |
Leishmania major | P-type ATPase, putative | 0.0044 | 0.2458 | 0.9637 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0025 | 0.0608 | 0.1103 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0045 | 0.2524 | 0.0451 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0044 | 0.2458 | 0.9738 |
Trypanosoma cruzi | calcium-transporting ATPase, putative | 0.0028 | 0.0852 | 0.3374 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0045 | 0.2524 | 0.8705 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8897 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0048 | 0.2795 | 1 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0045 | 0.2524 | 1 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0026 | 0.0703 | 0.035 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0045 | 0.2524 | 1 |
Schistosoma mansoni | ATPase | 0.0045 | 0.2524 | 0.0088 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.0103 | 0.8123 | 0.5 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0045 | 0.2524 | 1 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0048 | 0.2795 | 0.0468 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0045 | 0.2524 | 1 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0026 | 0.0703 | 0.2784 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.6301 | 0.6161 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0048 | 0.2795 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0119 | 0.9663 | 1 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0048 | 0.2795 | 0.0468 |
Schistosoma mansoni | ATPase | 0.0045 | 0.2524 | 0.0088 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0045 | 0.2524 | 1 |
Brugia malayi | E1-E2 ATPase family protein | 0.0029 | 0.0974 | 0.0722 |
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0028 | 0.0852 | 0.0597 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0106 | 0.8394 | 0.8349 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0045 | 0.2524 | 0.0092 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0026 | 0.0703 | 0.2784 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0048 | 0.2795 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0044 | 0.2458 | 0.8389 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0048 | 0.2795 | 1 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0048 | 0.2795 | 0.2131 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0044 | 0.2458 | 0.9738 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0045 | 0.2524 | 0.8705 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0048 | 0.2795 | 1 |
Loa Loa (eye worm) | calcium ATPase | 0.0025 | 0.0608 | 0.0252 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC99 (functional) | > 125 uM | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv using iron-replete GAST media after 10 to 14 days by broth microdilution assay | ChEMBL. | 23437866 |
MIC99 (functional) | > 125 uM | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv using iron-deficient GAST media after 10 to 14 days by broth microdilution assay | ChEMBL. | 23437866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.