TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 520.485 | Formula: C19H19F7N2O3S2
H donors: 1 H acceptors: 3 LogP: 4.58 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(c(c1)C(F)(F)F)N1CCN([C@@H](C1)C)S(=O)(=O)c1ccc(s1)C(C(F)(F)F)(O)C
InChi: 1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17?/m1/s1
InChiKey: KMOODFIUONBYCX-VCQTYVLVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	hydroxysteroid 11-beta dehydrogenase 1	Starlite/ChEMBL	References
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid 11-beta dehydrogenase 1	292 aa	246 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0036	0.0289	0.0928
Brugia malayi	Receptor family ligand binding region containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	FL cytokine receptor	0.0036	0.0289	0.0928
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0056	0.0585	1
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	protein tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Brugia malayi	SRC-1	0.0052	0.0523	0.1681
Echinococcus granulosus	protein tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0289	0.0928
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0317	0.0953
Echinococcus granulosus	activated cdc42 kinase 1	0.0036	0.0289	0.0928
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0036	0.0289	0.0928
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	epidermal growth factor receptor	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0052	0.0523	0.1681
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Echinococcus granulosus	aurora kinase A	0.0056	0.0585	0.1881
Echinococcus granulosus	activated cdc42 kinase 1	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Trypanosoma brucei	aurora B kinase	0.0056	0.0585	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Guanylyl cyclase protein 23	0.0036	0.0289	0.0928
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Schistosoma mansoni	protein tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	AUR protein kinase	0.0056	0.0585	0.1881
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	c src tyrosine kinase	0.0052	0.0523	0.1681
Echinococcus multilocularis	tyrosine protein kinase shark	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0038	0.0317	0.1018
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0523	0.1681
Loa Loa (eye worm)	SRC-1	0.0052	0.0523	0.1681
Echinococcus granulosus	tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FAK protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine kinase	0.0052	0.0523	0.1681
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	epidermal growth factor receptor	0.0036	0.0289	0.0928
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0056	0.0585	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0289	0.0928
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0036	0.0289	0.0928
Brugia malayi	Raf kinase	0.0036	0.0289	0.0928
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0208	0.067
Echinococcus multilocularis	transfer RNA-Thr	0.0036	0.0289	0.0928
Echinococcus granulosus	integrin linked protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0052	0.0523	0.1681
Giardia lamblia	Kinase, TTK	0.0222	0.3112	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0585	0.1881
Loa Loa (eye worm)	TK protein kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0052	0.0523	0.1681
Trichomonas vaginalis	CAMK family protein kinase	0.0222	0.3112	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/RYK protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	activin receptor type	0.0038	0.0317	0.1018
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Plasmodium falciparum	protein kinase, putative	0.0038	0.0317	0.0953
Echinococcus granulosus	ephrin type A receptor 4 A	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/ROR protein kinase	0.0036	0.0289	0.0928
Trypanosoma cruzi	aurora B kinase, putative	0.0056	0.0585	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0289	0.0928
Brugia malayi	ephrin receptor 1 precursor	0.0036	0.0289	0.0928
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0036	0.0289	0.0928
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/INSR protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0038	0.0317	0.1018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0056	0.0585	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0036	0.0289	0.0928
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0585	0.1051
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/ABL protein kinase	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TTK protein kinase	0.0222	0.3112	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0052	0.0523	0.1681
Brugia malayi	serine/threonine kinase 12	0.0056	0.0585	0.1881
Brugia malayi	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0222	0.3112	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Giardia lamblia	Aurora kinase	0.0056	0.0585	0.1051
Loa Loa (eye worm)	TK/ACK protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0036	0.0289	0.0928
Loa Loa (eye worm)	serine/threonine protein kinase	0.0036	0.0289	0.0928
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0056	0.0585	1
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Entamoeba histolytica	protein kinase domain containing protein	0.0056	0.0585	1
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0585	0.1051
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	aurora kinase A	0.0056	0.0585	0.1881
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Brugia malayi	protein-tyrosine kinase	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0036	0.0289	0.0928
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0052	0.0523	0.1681
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	ephrin receptor	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0222	0.3112	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Echinococcus granulosus	raf serine:threonine protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Brugia malayi	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	protein kinase	0.0036	0.0289	0.0928
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0036	0.0289	0.0928
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	c src tyrosine kinase	0.0052	0.0523	0.1681
Onchocerca volvulus		0.0036	0.0289	0.0928
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0052	0.0523	0.1681
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	kinase suppressor of Ras 1	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0036	0.0289	0.0928
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0289	0.0928
Brugia malayi	SH2 domain containing protein	0.0052	0.0523	0.1681
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase shark	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	integrin linked protein kinase	0.0036	0.0289	0.0928
Leishmania major	protein kinase, putative	0.0056	0.0585	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0052	0.0523	0.1681
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0056	0.0585	0.1881
Echinococcus multilocularis	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	insulin receptor	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.0317	0.0953
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0052	0.0523	0.1681
Brugia malayi	C-terminal src kinase protein 1	0.0036	0.0289	0.0928
Entamoeba histolytica	protein kinase , putative	0.0056	0.0585	1
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0036	0.0289	0.0928
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0317	0.0953
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/Met protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Onchocerca volvulus		0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0523	0.1681
Schistosoma mansoni	protein kinase	0.0038	0.0317	0.1018
Loa Loa (eye worm)	TK/DDR protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0222	0.3112	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Brugia malayi	serine/threonine protein kinase 6	0.0056	0.0585	0.1881
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0052	0.0523	0.1681
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0052	0.0523	0.7895
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Brugia malayi	hypothetical protein	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0036	0.0289	0.0928
Echinococcus multilocularis	activin receptor type	0.0038	0.0317	0.1018
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Trichomonas vaginalis	CAMK family protein kinase	0.0222	0.3112	1
Echinococcus granulosus	epidermal growth factor receptor	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/CSK protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0038	0.0317	0.1018
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0056	0.0585	1
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0585	0.1051
Loa Loa (eye worm)	TK/FER protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	AUR protein kinase	0.0056	0.0585	0.1881
Loa Loa (eye worm)	TK/FER protein kinase	0.0052	0.0523	0.1681
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0052	0.0523	0.1681
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0036	0.0289	0.0928
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0052	0.0523	0.1681
Brugia malayi	serine/threonine-protein kinase 6	0.0056	0.0585	0.1881
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0052	0.0523	0.1681
Brugia malayi	Tyrosine-protein kinase PR2	0.0036	0.0289	0.0928
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0052	0.0523	0.1681
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0038	0.0317	0.1018
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0222	0.3112	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	serine/threonine RGC	0.0036	0.0289	0.0928
Echinococcus multilocularis	activated cdc42 kinase 1	0.0036	0.0289	0.0928
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0038	0.0317	0.0953
Echinococcus granulosus	tyrosine kinase	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine kinase	0.0052	0.0523	0.1681
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus	Tyrosine kinase homolog	0.0036	0.0289	0.0928
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0036	0.0289	0.0928
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	heat shock protein 70	0.0036	0.0289	0.0928
Schistosoma mansoni	ephrin receptor	0.0036	0.0289	0.0928
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0036	0.0289	0.0928
Echinococcus multilocularis	protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Tyrosine-protein kinase abl-1	0.0052	0.0523	0.1681
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0317	0.0953
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0054	0.0551	0.1772
Toxoplasma gondii	aurora kinase	0.0056	0.0585	1
Schistosoma mansoni	tyrosine protein kinase	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0052	0.0523	0.1681
Schistosoma mansoni	protein kinase	0.0056	0.0585	0.1881
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Entamoeba histolytica	protein kinase, putative	0.0056	0.0585	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/ALK protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0036	0.0289	0.0928
Onchocerca volvulus		0.0052	0.0523	0.1681
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Brugia malayi	Furin-like cysteine rich region family protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0052	0.0523	0.1681
Entamoeba histolytica	protein kinase, putative	0.0056	0.0585	1
Echinococcus multilocularis	insulin receptor	0.0036	0.0289	0.0928
Trypanosoma brucei	protein kinase, putative	0.0038	0.0317	0.0953
Onchocerca volvulus		0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0052	0.0523	0.1681
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0052	0.0523	0.1681
Echinococcus granulosus	natriuretic peptide receptor 1	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0036	0.0289	0.0928
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Leishmania major	protein kinase, putative	0.0038	0.0317	0.0953
Echinococcus granulosus	protein kinase	0.0036	0.0289	0.0928
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0056	0.0585	0.1881
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Echinococcus granulosus	tyrosine protein kinase pr2	0.0036	0.0289	0.0928
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Loa Loa (eye worm)	AUR protein kinase	0.0056	0.0585	0.1881
Echinococcus granulosus	tyrosine protein kinase Blk	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0585	0.1051
Brugia malayi	SH2 domain containing protein	0.0052	0.0523	0.1681
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0289	0.0928
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0222	0.3112	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0036	0.0289	0.0928
Schistosoma mansoni	protein kinase	0.0036	0.0289	0.0928
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0052	0.0523	0.1681
Brugia malayi	integrin-linked kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	TK/EPH protein kinase	0.0036	0.0289	0.0928
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0289	0.0928
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0208	0.067
Echinococcus granulosus	receptor type guanylyl cyclase	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0036	0.0289	0.0928
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0052	0.0523	0.1681
Schistosoma mansoni	tyrosine kinase	0.0036	0.0289	0.0928

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.01 uM	Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay in presence of 10% human serum	ChEMBL.	24900572
IC50 (binding)	= 0.01 uM	Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay	ChEMBL.	24900572
IC50 (binding)	= 0.015 uM	Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay	ChEMBL.	24900572
Inhibition (functional)	= 44 %	Ex vivo inhibition of 11beta-HSD1 in C57B16 mouse epididymal fat assessed as conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po after 5 hrs by HPLC analysis relative to vehicle-treated control	ChEMBL.	24900572

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2322704

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1726257