Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.017 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.001 | 0.0009 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.0297 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.1132 | 0.5022 | 0.5022 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0234 | 0.0892 | 0.1504 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.133 | 0.5931 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0077 | 0.017 | 0.0286 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.0362 | 1 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0222 | 0.0841 | 0.1417 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0234 | 0.0892 | 0.0892 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.017 | 0.017 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.133 | 0.5931 | 0.5931 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0222 | 0.0841 | 0.1417 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.0192 | 0.5294 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.133 | 0.5931 | 1 |
Onchocerca volvulus | 0.0234 | 0.0892 | 0.1503 | |
Echinococcus multilocularis | serotonin transporter | 0.0234 | 0.0892 | 0.1503 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0234 | 0.0892 | 0.0892 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.0362 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.0362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0892 | 0.0892 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.0362 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.133 | 0.5931 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.133 | 0.5931 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.133 | 0.5931 | 0.5931 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.0362 | 0.0362 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.0346 | 0.9555 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.0362 | 0.0362 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0234 | 0.0892 | 0.1504 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0234 | 0.0892 | 0.0892 |
Echinococcus granulosus | serotonin transporter | 0.0234 | 0.0892 | 0.1503 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.0059 | 0.1637 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.073 | 0.0729 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.0081 | 0.5 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0222 | 0.0841 | 0.1418 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.0251 | 0.6931 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.0251 | 0.6931 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0077 | 0.017 | 0.0286 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0234 | 0.0892 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0892 | 0.0892 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.0192 | 0.5294 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | serotonin transporter b | 0.0234 | 0.0892 | 0.0892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 0.5 nM | Inhibition of recombinant PI3Kalpha (unknown origin)-mediated 3,4,5-inositoltriphosphate formation after 30 mins by TAMRA-PIP3-based competitive fluorescence polarization assay | ChEMBL. | 23265894 |
IC50 (binding) | = 0.042 uM | Inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in human PC3 cells | ChEMBL. | 23265894 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.