TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 672.618 | Formula: C35H33N2O10P
H donors: 4 H acceptors: 6 LogP: 4.4 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)OCC1c2ccccc2c2c1cccc2)Cc1ccc2c(c1)COP(=O)(O2)O
InChi: 1S/C35H33N2O10P/c1-44-34(40)31(18-22-12-15-32-23(16-22)19-46-48(42,43)47-32)36-33(39)30(17-21-10-13-24(38)14-11-21)37-35(41)45-20-29-27-8-4-2-6-25(27)26-7-3-5-9-28(26)29/h2-16,29-31,38H,17-20H2,1H3,(H,36,39)(H,37,41)(H,42,43)/t30-,31-/m0/s1
InChiKey: OKIRDOUBFYPCKB-CONSDPRKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0575	0.1092	0.1174
Schistosoma mansoni	integrin alpha-ps	0.0539	0.1018	0.1094
Schistosoma mansoni	tyrosine kinase	0.0095	0.0114	0.0122
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0291	0.0512	0.0656
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0575	0.1092	0.1092
Echinococcus multilocularis	potassium voltage gated channel protein	0.052	0.0979	0.1252
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0497	0.0933	0.1193
Echinococcus multilocularis	voltage gated potassium channel	0.0045	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0045	0.001	0.0005
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0575	0.1092	0.1398
Toxoplasma gondii	PAN domain-containing protein	0.0178	0.0281	0.0737
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	neuropeptide F-like receptor	0.0575	0.1092	0.1174
Schistosoma mansoni	serine-type protease inhibitor	0.4602	0.9302	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0189	0.0303	0.0388
Schistosoma mansoni	integrin alpha-4	0.0391	0.0716	0.077
Onchocerca volvulus		0.0182	0.0291	0.0628
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	glutamate receptor 2	0.0091	0.0105	0.0134
Echinococcus multilocularis	serotonin receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	neuropeptides capa receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Echinococcus granulosus	G protein coupled receptor 139	0.0575	0.1092	0.1398
Echinococcus multilocularis	sex peptide receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0091	0.0105	0.0134
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0575	0.1092	0.1174
Brugia malayi	GnHR receptor homolog	0.0575	0.1092	0.1092
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0194	0.0315	0.0403
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0227	0.0381	0.0488
Schistosoma mansoni	neuropeptide receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	tyrosine kinase	0.0108	0.0139	0.0149
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Echinococcus multilocularis	potassium voltage gated channel protein	0.0045	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Echinococcus multilocularis	shaker cognate	0.0045	0.001	0.0013
Onchocerca volvulus		0.0416	0.0768	0.2239
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0197	0.032	0.041
Brugia malayi	excitatory GABA receptor EXP-1A	0.0416	0.0768	0.0768
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Brugia malayi	ORL1-like opioid receptor	0.0575	0.1092	0.1092
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0146	0.0216	0.0376
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0066	0.0053	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Onchocerca volvulus		0.0317	0.0565	0.1552
Schistosoma mansoni	hypothetical protein	0.0258	0.0446	0.0479
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0194	0.0315	0.0403
Echinococcus multilocularis	glycine receptor subunit beta	0.0416	0.0768	0.0983
Schistosoma mansoni	growth factor receptor-bound protein	0.0044	0.0008	0.0009
Schistosoma mansoni	adenoreceptor	0.0575	0.1092	0.1174
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Schistosoma mansoni	tyrosine kinase	0.0164	0.0253	0.0272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Schistosoma mansoni	neuropeptide receptor	0.1501	0.2981	0.3204
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0091	0.0105	0.0134
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0197	0.032	0.041
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Brugia malayi	Variant SH3 domain containing protein	0.0044	0.0008	0.0008
Toxoplasma gondii	PAN domain-containing protein	0.188	0.3753	1
Onchocerca volvulus		0.0575	0.1092	0.3332
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0091	0.0105	0.0134
Echinococcus multilocularis	neuropeptide s receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	serotonin receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Schistosoma mansoni	amine GPCR	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	voltage dependent calcium channel	0.0128	0.018	0.0231
Loa Loa (eye worm)	SRC-1	0.0232	0.0393	0.0388
Loa Loa (eye worm)	ACC-1 protein	0.0416	0.0768	0.0764
Echinococcus multilocularis	glycoprotein Antigen 5	0.0227	0.0381	0.0488
Loa Loa (eye worm)	melatonin receptor type 1A	0.0575	0.1092	0.1087
Echinococcus granulosus	neuropeptide receptor	0.1501	0.2981	0.3815
Onchocerca volvulus		0.0575	0.1092	0.3332
Onchocerca volvulus		0.0197	0.032	0.0727
Toxoplasma gondii	subtilisin SUB12	0.0178	0.0281	0.0737
Onchocerca volvulus		0.0416	0.0768	0.2239
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.022	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Onchocerca volvulus		0.0575	0.1092	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.1544	0.3068	0.3064
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	GABA receptor subunit	0.022	0.0367	0.0362
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0575	0.1092	0.1087
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0485	0.0909	0.1163
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0091	0.0105	0.0105
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Onchocerca volvulus		0.0182	0.0291	0.0628
Echinococcus granulosus	kelch ECH associated protein 1	0.0093	0.011	0.014
Schistosoma mansoni	neurotransmitter gated ion channel	0.022	0.0367	0.0395
Echinococcus multilocularis	fibrillin 2	0.0146	0.0216	0.0277
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Brugia malayi	RE15519p	0.0575	0.1092	0.1092
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0035	0.003
Echinococcus granulosus	fibrillin 1	0.0146	0.0216	0.0277
Echinococcus multilocularis	enteropeptidase	0.0227	0.0381	0.0488
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0575	0.1092	0.1174
Echinococcus granulosus	potassium voltage gated channel protein	0.0045	0.001	0.0013
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0128	0.018	0.0231
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0197	0.032	0.0344
Schistosoma mansoni	tyrosine kinase	0.006	0.0042	0.0046
Echinococcus granulosus	c src tyrosine kinase	0.006	0.0042	0.0054
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0575	0.1092	0.3332
Toxoplasma gondii	microneme protein, putative	0.0178	0.0281	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Brugia malayi	Muscle positioning protein 4	0.0187	0.03	0.03
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0575	0.1092	0.1174
Echinococcus granulosus	g protein coupled receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	nAChR subunit	0.0197	0.032	0.0344
Echinococcus multilocularis	glutamate receptor 2	0.0091	0.0105	0.0134
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.011	0.014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Echinococcus granulosus	serotonin receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0211	0.0349	0.0446
Echinococcus granulosus	g protein coupled receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	sodium channel protein	0.0066	0.0053	0.0068
Giardia lamblia	hypothetical protein	0.0146	0.0216	0.5
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.052	0.0979	0.0979
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0575	0.1092	0.1398
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Schistosoma mansoni	metabotropic glutamate receptor	0.0091	0.0105	0.0113
Schistosoma mansoni	opsin-like receptor	0.0575	0.1092	0.1174
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0232	0.0393	0.0503
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Echinococcus multilocularis	g protein coupled receptor	0.0575	0.1092	0.1398
Brugia malayi	Dopamine receptor protein 2	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	neuropeptide receptor A26	0.0575	0.1092	0.1398
Brugia malayi	hypothetical protein	0.0227	0.0381	0.0381
Brugia malayi	EGF-like domain containing protein	0.0146	0.0216	0.0216
Brugia malayi	Cation transporter family protein	0.1015	0.1988	0.1988
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.011	0.014
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0232	0.0393	0.0503
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0216	0.0211
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0485	0.0909	0.1163
Schistosoma mansoni	growth factor receptor-bound protein	0.0044	0.0008	0.0009
Loa Loa (eye worm)	glutamate receptor	0.0091	0.0105	0.01
Onchocerca volvulus		0.0178	0.0281	0.0596
Toxoplasma gondii	kringle domain-containing protein	0.0317	0.0565	0.1493
Onchocerca volvulus		0.0575	0.1092	0.3332
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0416	0.0768	0.0764
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0197	0.032	0.041
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0105	0.0133	0.017
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Toxoplasma gondii	hypothetical protein	0.0146	0.0216	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0091	0.0105	0.0134
Echinococcus multilocularis	dro:myosuppressin receptor	0.0575	0.1092	0.1398
Brugia malayi	Furin-like cysteine rich region family protein	0.0164	0.0253	0.0253
Echinococcus multilocularis	epidermal growth factor receptor	0.0164	0.0253	0.0324
Leishmania major	hypothetical protein, conserved	0.0317	0.0565	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0575	0.1092	0.1398
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0575	0.1092	0.1398
Echinococcus granulosus	tm gpcr rhodopsin	0.2146	0.4296	0.5498
Giardia lamblia	Tenascin-X	0.0146	0.0216	0.5
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Schistosoma mansoni	tyrosine kinase	0.0079	0.008	0.0085
Echinococcus granulosus	integrin alpha ps	0.0258	0.0446	0.0571
Echinococcus multilocularis	epidermal growth factor receptor	0.0095	0.0114	0.0145
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0381	0.0376
Echinococcus granulosus	NCK adaptor protein	0.0044	0.0008	0.0011
Brugia malayi	EGF-like domain containing protein	0.0146	0.0216	0.0216
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0252	0.0432	0.0553
Loa Loa (eye worm)	TK/ROR protein kinase	0.0333	0.0599	0.0594
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0252	0.0432	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0045	0.001	0.001
Loa Loa (eye worm)	LGC-31 protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Schistosoma mansoni	nck2/grb4	0.0044	0.0008	0.0009
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0416	0.0768	0.0983
Echinococcus multilocularis	potassium voltage gated channel protein	0.0045	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0799	0.1548	0.1544
Onchocerca volvulus		0.0187	0.03	0.0658
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0291	0.0512	0.1375
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0128	0.018	0.0231
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Echinococcus multilocularis	integrin alpha ps	0.0539	0.1018	0.1303
Schistosoma mansoni	neuropeptide receptor	0.0575	0.1092	0.1174
Brugia malayi	hypothetical protein	0.0197	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Schistosoma mansoni	histamine h1 receptor	0.0575	0.1092	0.1174
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0091	0.0105	0.0134
Echinococcus multilocularis	allatostatin A receptor	0.0575	0.1092	0.1398
Brugia malayi	hypothetical protein	0.0091	0.0105	0.0105
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0197	0.032	0.041
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Onchocerca volvulus		0.0197	0.032	0.0727
Brugia malayi	hypothetical protein	0.0197	0.032	0.032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Giardia lamblia	Neurogenic locus notch-like protein	0.0146	0.0216	0.5
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0178	0.0281	0.0737
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0416	0.0768	0.0768
Toxoplasma gondii	PAN domain-containing protein	0.0178	0.0281	0.0737
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0317	0.0565	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0044	0.0008	0.0003
Onchocerca volvulus		0.0575	0.1092	0.3332
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Schistosoma mansoni	amine GPCR	0.0575	0.1092	0.1174
Schistosoma mansoni	hypothetical protein	0.0094	0.011	0.0118
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0232	0.0393	0.0503
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0416	0.0768	0.0826
Schistosoma mansoni	growth hormone secretagogue receptor	0.0575	0.1092	0.1174
Onchocerca volvulus		0.0178	0.0281	0.0596
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0485	0.0909	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0187	0.03	0.0295
Echinococcus multilocularis	nAChR subunit	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0035	0.003
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.1015	0.1988	0.2137
Toxoplasma gondii	microneme protein MIC4	0.0178	0.0281	0.0737
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0128	0.018	0.0231
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0381	0.0376
Onchocerca volvulus	Putative nachr subunit	0.0485	0.0909	0.2713
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0232	0.0393	0.0503
Echinococcus multilocularis	glutamate receptor 2	0.0091	0.0105	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Onchocerca volvulus		0.0182	0.0291	0.0628
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0091	0.0105	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0416	0.0768	0.0768
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0575	0.1092	0.1174
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0232	0.0393	0.0503
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0575	0.1092	0.1174
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0827	0.1606	0.1602
Echinococcus multilocularis	g protein coupled receptor	0.0575	0.1092	0.1398
Brugia malayi	Kelch motif family protein	0.0827	0.1606	0.1606
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0044	0.0008	0.0011
Echinococcus granulosus	neuropeptide receptor	0.0575	0.1092	0.1398
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.022	0.0367	0.0367
Echinococcus granulosus	epidermal growth factor receptor	0.0095	0.0114	0.0145
Echinococcus granulosus	fmrfamide receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	acetylcholine receptor-related	0.0197	0.032	0.0344
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0485	0.0909	0.0904
Brugia malayi	Dopamine receptor	0.0575	0.1092	0.1092
Echinococcus granulosus	hypothetical protein	0.0575	0.1092	0.1398
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0045	0.001	0.001
Echinococcus multilocularis	c src tyrosine kinase	0.006	0.0042	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1606	0.3194	0.3433
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0091	0.0105	0.0134
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0164	0.0253	0.0248
Loa Loa (eye worm)	DOMON domain-containing protein	0.0182	0.0291	0.0286
Echinococcus granulosus	Mastin	0.0227	0.0381	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	neuropeptide F receptor	0.0575	0.1092	0.1092
Brugia malayi	Cation transporter family protein	0.0416	0.0768	0.0768
Brugia malayi	Melatonin receptor type 1A	0.0575	0.1092	0.1092
Onchocerca volvulus		0.0227	0.0381	0.0933
Loa Loa (eye worm)	G-protein coupled receptor	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.0042	0.0054
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.001	0.0013
Echinococcus multilocularis	tissue type plasminogen activator	0.0317	0.0565	0.0723
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0105	0.0133	0.017
Schistosoma mansoni	tyrosine kinase	0.0079	0.008	0.0085
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0128	0.018	0.0231
Echinococcus multilocularis	Kelch repeat type 1	0.0094	0.011	0.0141
Brugia malayi	Protein kinase domain containing protein	0.0333	0.0599	0.0599
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0197	0.032	0.041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	putative neuropeptide receptor NPR1	0.0575	0.1092	0.1092
Echinococcus granulosus	nmda type glutamate receptor	0.0091	0.0105	0.0134
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0091	0.0105	0.01
Loa Loa (eye worm)	hypothetical protein	0.0831	0.1614	0.161
Loa Loa (eye worm)	neuropeptide F receptor	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.1015	0.1988	0.1984
Toxoplasma gondii	hypothetical protein	0.0178	0.0281	0.0737
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0227	0.0381	0.041
Echinococcus granulosus	nAChR subunit	0.0416	0.0768	0.0983
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.022	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	somatostatin receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Echinococcus multilocularis	nAChR subunit	0.022	0.0367	0.047
Echinococcus granulosus	tyrosine protein kinase HCK	0.0189	0.0303	0.0388
Echinococcus multilocularis	adam	0.0146	0.0216	0.0277
Loa Loa (eye worm)	hypothetical protein	0.1015	0.1988	0.1984
Entamoeba histolytica	protein kinase, putative	0.0189	0.0304	0.8267
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0091	0.0105	0.01
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Schistosoma mansoni	neuropeptide receptor	0.0575	0.1092	0.1174
Toxoplasma gondii	microneme protein MIC17B	0.0178	0.0281	0.0737
Schistosoma mansoni	hypothetical protein	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Loa Loa (eye worm)	TYRA-2 protein	0.0575	0.1092	0.1087
Schistosoma mansoni	neurotransmitter gated ion channel	0.0197	0.032	0.0344
Brugia malayi	Serotonin receptor	0.0575	0.1092	0.1092
Echinococcus multilocularis	integrin alpha ps	0.0258	0.0446	0.0571
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0095	0.0114	0.0145
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0091	0.0105	0.0134
Loa Loa (eye worm)	PAN domain-containing protein	0.0178	0.0281	0.0276
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0128	0.018	0.0194
Plasmodium falciparum	cysteine repeat modular protein 1	0.0317	0.0565	0.5
Onchocerca volvulus		0.0227	0.0381	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	adapter molecule crk	0.0044	0.0008	0.0009
Schistosoma mansoni	neurotransmitter gated ion channel	0.0197	0.032	0.0344
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0416	0.0768	0.0768
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	opsin-like receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Giardia lamblia	Tenascin precursor	0.0146	0.0216	0.5
Brugia malayi	protein-tyrosine kinase	0.0211	0.0349	0.0349
Loa Loa (eye worm)	integrin alpha pat-2	0.1414	0.2802	0.2798
Echinococcus granulosus	voltage dependent calcium channel	0.0042	0.0005	0.0007
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0416	0.0768	0.0764
Echinococcus multilocularis	fmrfamide receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	g-protein coupled receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	sex peptide receptor	0.0575	0.1092	0.1398
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0139	0.0134
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0044	0.0008	0.0003
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0128	0.018	0.0231
Brugia malayi	Serotonin receptor	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0575	0.1092	0.1398
Loa Loa (eye worm)	G-protein coupled receptor	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0575	0.1092	0.1087
Echinococcus granulosus	neuropeptide s receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0045	0.004
Echinococcus granulosus	neuropeptide Y receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0063	0.0048	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Onchocerca volvulus		0.0575	0.1092	0.3332
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	tyrosine kinase	0.0232	0.0393	0.0422
Onchocerca volvulus		0.0178	0.0281	0.0596
Schistosoma mansoni	neuropeptide f receptor 76f	0.0575	0.1092	0.1174
Giardia lamblia	Tenascin-37	0.0146	0.0216	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0045	0.001	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Brugia malayi	Sex muscle abnormal protein 5	0.0044	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0291	0.0286
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0575	0.1092	0.1174
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0575	0.1092	0.1092
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.0054	0.0048
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0575	0.1092	0.1398
Brugia malayi	Trypsin family protein	0.0227	0.0381	0.0381
Giardia lamblia	High cysteine protein	0.0146	0.0216	0.5
Echinococcus granulosus	shaker cognate	0.0045	0.001	0.0013
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0416	0.0768	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0258	0.0446	0.0441
Onchocerca volvulus		0.0178	0.0281	0.0596
Brugia malayi	Receptor family ligand binding region containing protein	0.0091	0.0105	0.0105
Echinococcus multilocularis	integrin beta 2	0.3871	0.7814	1
Brugia malayi	Variant SH3 domain containing protein	0.0044	0.0008	0.0008
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0091	0.0105	0.0134
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0227	0.0381	0.0381
Schistosoma mansoni	tyrosine kinase	0.0063	0.0048	0.0051
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Schistosoma mansoni	neuropeptide F-like receptor	0.0575	0.1092	0.1174
Echinococcus multilocularis	neuropeptide Y receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0818	0.1587	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Toxoplasma gondii	microneme protein MIC17C	0.0178	0.0281	0.0737
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.1544	0.3068	0.3064
Echinococcus granulosus	g protein coupled receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	glycoprotein Antigen 5	0.0227	0.0381	0.0488
Schistosoma mansoni	tyrosine kinase	0.0108	0.0139	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0491	0.0486
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Brugia malayi	AKH receptor	0.0575	0.1092	0.1092
Schistosoma mansoni	vesicular amine transporter	0.0045	0.001	0.0011
Echinococcus granulosus	somatostatin receptor	0.0575	0.1092	0.1398
Brugia malayi	CUB domain containing protein	0.0062	0.0045	0.0045
Brugia malayi	Guanylyl cyclase protein 23	0.013	0.0185	0.0185
Brugia malayi	Trypsin family protein	0.0227	0.0381	0.0381
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0232	0.0393	0.0503
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.011	0.014
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Trypanosoma cruzi	extracellular receptor, putative	0.0091	0.0105	0.0237
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.022	0.0367	0.0367
Echinococcus granulosus	tissue type plasminogen activator	0.0317	0.0565	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0216	0.0211
Schistosoma mansoni	jumonji domain containing protein	0.0083	0.0089	0.0095
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0485	0.0909	0.0904
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0416	0.0768	0.0983
Loa Loa (eye worm)	ACC-1 protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0317	0.0565	0.056
Brugia malayi	hypothetical protein	0.0197	0.032	0.032
Onchocerca volvulus		0.0575	0.1092	0.3332
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0575	0.1092	0.1398
Toxoplasma gondii	PAN domain-containing protein	0.188	0.3753	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0381	0.0376
Echinococcus granulosus	voltage gated potassium channel	0.0045	0.001	0.0013
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0575	0.1092	0.1087
Brugia malayi	Cation transporter family protein	0.0416	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Brugia malayi	Tyrosine-protein kinase abl-1	0.006	0.0042	0.0042
Schistosoma mansoni	myosin xvIII	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Echinococcus granulosus	integrin alpha ps	0.0539	0.1018	0.1303
Brugia malayi	Kringle domain containing protein	0.0317	0.0565	0.0565
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0232	0.0393	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0063	0.0048	0.0061
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0091	0.0105	0.0105
Toxoplasma gondii	hypothetical protein	0.0178	0.0281	0.0737
Schistosoma mansoni	hypothetical protein	0.0227	0.0381	0.041
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0416	0.0768	0.0983
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	PAN domain-containing protein	0.0178	0.0281	0.0276
Echinococcus granulosus	nAChR subunit	0.022	0.0367	0.047
Onchocerca volvulus		0.1015	0.1988	0.6357
Giardia lamblia	Neurogenic locus Notch protein precursor	0.0146	0.0216	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0255	0.0439	0.0472
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0575	0.1092	0.1092
Schistosoma mansoni	biogenic amine receptor	0.0575	0.1092	0.1174
Brugia malayi	hypothetical protein	0.0197	0.032	0.032
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0128	0.018	0.0231
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0575	0.1092	0.1087
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.022	0.0367	0.0395
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0381	0.041
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0485	0.0909	0.1163
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0091	0.0105	0.01
Schistosoma mansoni	tyrosine kinase	0.0063	0.0048	0.0051
Brugia malayi	sulfakinin receptor protein	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Onchocerca volvulus		0.022	0.0367	0.0885
Brugia malayi	Trypsin family protein	0.1544	0.3068	0.3068
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0035	0.0035
Brugia malayi	Trypsin-like protease protein 5	0.0227	0.0381	0.0381
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0227	0.0381	0.0488
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0381	0.041
Brugia malayi	G-protein coupled receptor	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0031	0.0026
Echinococcus multilocularis	tyrosine protein kinase Abl	0.006	0.0042	0.0054
Echinococcus granulosus	enteropeptidase	0.0227	0.0381	0.0488
Onchocerca volvulus		0.0575	0.1092	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0575	0.1092	0.1174
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Echinococcus granulosus	tyrosine kinase	0.0211	0.0349	0.0446
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Schistosoma mansoni	hypothetical protein	0.0317	0.0565	0.0607
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0416	0.0768	0.0768
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Loa Loa (eye worm)	acetylcholine receptor protein	0.0197	0.032	0.0315
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0416	0.0768	0.0983
Echinococcus multilocularis	transfer RNA-Gly	0.0045	0.001	0.0013
Echinococcus granulosus	allatostatin A receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0128	0.018	0.0194
Echinococcus granulosus	integrin alpha 3	0.0809	0.1569	0.2008
Brugia malayi	hypothetical protein	0.0197	0.032	0.032
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0128	0.018	0.018
Loa Loa (eye worm)	neuropeptide F receptor	0.0575	0.1092	0.1087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0381	0.0376
Brugia malayi	jmjC domain containing protein	0.0105	0.0133	0.0133
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.001	0.0013
Echinococcus granulosus	growth factor receptor bound protein 2	0.0044	0.0008	0.0011
Echinococcus granulosus	7tm_1 domain containing protein	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0575	0.1092	0.3332
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0575	0.1092	0.1398
Schistosoma mansoni	hypothetical protein	0.0182	0.0291	0.0313
Echinococcus granulosus	integrin beta 2	0.3871	0.7814	1
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0045	0.001	0.0013
Brugia malayi	SEA domain containing protein	0.0182	0.0291	0.0291
Echinococcus granulosus	potassium voltage gated channel protein	0.052	0.0979	0.1252
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Schistosoma mansoni	hypothetical protein	0.0057	0.0035	0.0038
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Trichomonas vaginalis	hypothetical protein	0.0146	0.0216	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0227	0.0381	0.0933
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0211	0.0349	0.0446
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0416	0.0768	0.0768
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0416	0.0768	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	tyrosine kinase	0.0108	0.0139	0.0178
Echinococcus multilocularis	fmrfamide receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	voltage dependent calcium channel	0.0128	0.018	0.0231
Mycobacterium ulcerans	hypothetical protein	0.0227	0.0381	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0575	0.1092	0.1092
Brugia malayi	G protein-coupled receptor F59B2.13	0.0575	0.1092	0.1092
Schistosoma mansoni	hypothetical protein	0.0575	0.1092	0.1174
Echinococcus granulosus	insulin receptor	0.0063	0.0048	0.0061
Echinococcus granulosus	neuropeptide FF receptor 2	0.0575	0.1092	0.1398
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0197	0.032	0.0315
Echinococcus granulosus	receptor type guanylyl cyclase	0.0291	0.0512	0.0656
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0575	0.1092	0.1092
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0575	0.1092	0.1174
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0583	0.1107	0.1107
Schistosoma mansoni	biogenic amine receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	tyrosine protein kinase Blk	0.0211	0.0349	0.0446
Echinococcus granulosus	glycine receptor subunit beta	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Schistosoma mansoni	hypothetical protein	0.0575	0.1092	0.1174
Schistosoma mansoni	tyrosine kinase	0.006	0.0042	0.0046
Loa Loa (eye worm)	voltage-gated potassium channel	0.0045	0.001	0.0005
Brugia malayi	hypothetical protein	0.0799	0.1548	0.1548
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0416	0.0768	0.0983
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0232	0.0393	0.0503
Schistosoma mansoni	tyrosine kinase	0.0095	0.0114	0.0122
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Echinococcus multilocularis	Mastin	0.0227	0.0381	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0485	0.0909	0.1163
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0575	0.1092	0.1174
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1544	0.3068	0.3298
Echinococcus granulosus	potassium voltage gated channel protein	0.0045	0.001	0.0013
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0416	0.0768	0.0983
Brugia malayi	larval opioid receptor	0.0575	0.1092	0.1092
Onchocerca volvulus		0.0575	0.1092	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0128	0.018	0.0175
Echinococcus granulosus	7TM GPCR rhodopsin	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0583	0.1107	0.1103
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.1015	0.1988	0.2137
Onchocerca volvulus		0.013	0.0185	0.027
Echinococcus multilocularis	orexin receptor type 2	0.0575	0.1092	0.1398
Schistosoma mansoni	glutamate receptor NMDA	0.0091	0.0105	0.0113
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0416	0.0768	0.0983
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0575	0.1092	0.1398
Onchocerca volvulus		0.1317	0.2606	0.844
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis		0.0046	0.0012	0.0016
Entamoeba histolytica	hypothetical protein	0.0091	0.0105	0.2855
Brugia malayi	neuropeptide F receptor	0.0575	0.1092	0.1092
Echinococcus multilocularis	glycine receptor subunit beta	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus multilocularis	neuropeptide receptor	0.1501	0.2981	0.3815
Onchocerca volvulus		0.022	0.0367	0.0885
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0197	0.032	0.032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Echinococcus multilocularis	neuropeptides capa receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	protein kinase	0.0291	0.0512	0.0551
Echinococcus granulosus	neuropeptide receptor A26	0.0575	0.1092	0.1398
Echinococcus granulosus	fibrillin 2	0.0146	0.0216	0.0277
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0416	0.0768	0.0768
Schistosoma mansoni	opsin-like receptor	0.0575	0.1092	0.1174
Echinococcus granulosus	glutamate receptor 2	0.0091	0.0105	0.0134
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0086	0.0094	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Brugia malayi	metabotropic glutamate receptor type 2	0.0091	0.0105	0.0105
Echinococcus granulosus	neuropeptides capa receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0128	0.018	0.0231
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.052	0.0979	0.0974
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0416	0.0768	0.0768
Brugia malayi	G protein-coupled receptor	0.0575	0.1092	0.1092
Brugia malayi	putative neuropeptide receptor	0.0575	0.1092	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0381	0.0376
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Schistosoma mansoni	amine GPCR	0.0575	0.1092	0.1174
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0178	0.0281	0.0737
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.022	0.0367	0.0395
Brugia malayi	follicle stimulating hormone receptor	0.0575	0.1092	0.1092
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0575	0.1092	0.1398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Brugia malayi	PAN domain containing protein	0.0178	0.0281	0.0281
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Onchocerca volvulus		0.0227	0.0381	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0416	0.0768	0.0768
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0575	0.1092	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0551	0.1042	0.1037
Toxoplasma gondii	microneme protein MIC17A	0.0178	0.0281	0.0737
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Brugia malayi	Dopamine receptor protein 1	0.0575	0.1092	0.1092
Echinococcus multilocularis	protein jagged 2	0.0146	0.0216	0.0277
Schistosoma mansoni	biogenic amine receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0281	0.0276
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0045	0.001	0.0013
Brugia malayi	Receptor family ligand binding region containing protein	0.0291	0.0512	0.0512
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0044	0.0008	0.0009
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0416	0.0768	0.0764
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.0042	0.0046
Schistosoma mansoni	metabotropic glutamate receptor	0.0091	0.0105	0.0113
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0197	0.032	0.032
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0045	0.001	0.0013
Toxoplasma gondii	PAN domain-containing protein	0.0178	0.0281	0.0737
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0381	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0575	0.1092	0.1398
Echinococcus granulosus	orexin receptor type 2	0.0575	0.1092	0.1398
Loa Loa (eye worm)	TK protein kinase	0.0189	0.0303	0.0298
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0416	0.0768	0.0768
Echinococcus multilocularis	nmda type glutamate receptor	0.0091	0.0105	0.0134
Brugia malayi	G-protein coupled receptor	0.0575	0.1092	0.1092
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0485	0.0909	0.1163
Echinococcus granulosus	dro:myosuppressin receptor	0.0575	0.1092	0.1398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.006	0.0042	0.0054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0575	0.1092	0.1398
Brugia malayi	Trypsin family protein	0.0227	0.0381	0.0381
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Brugia malayi	SRC-1	0.0232	0.0393	0.0393
Loa Loa (eye worm)	PAN domain-containing protein	0.0178	0.0281	0.0276
Echinococcus granulosus	tm gpcr rhodopsin	0.0575	0.1092	0.1398
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0091	0.0105	0.0134
Onchocerca volvulus		0.1015	0.1988	0.6357
Schistosoma mansoni	tyrosine kinase	0.0079	0.008	0.0085
Loa Loa (eye worm)	hypothetical protein	0.022	0.0367	0.0362
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0575	0.1092	0.1398
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0381	0.041
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0197	0.032	0.032
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0045	0.001	0.0013
Echinococcus granulosus	adam	0.0146	0.0216	0.0277
Schistosoma mansoni	nAChR subunit	0.0416	0.0768	0.0826
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus granulosus	neuropeptides capa receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	voltage-gated cation channel	0.0128	0.018	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0091	0.0105	0.0134
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0227	0.0381	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Giardia lamblia	Tenascin-like	0.0146	0.0216	0.5
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Schistosoma mansoni	amine GPCR	0.0575	0.1092	0.1174
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0045	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0216	0.0211
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.011	0.014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0575	0.1092	0.1398
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0232	0.0393	0.0503
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	RGC/RGC protein kinase	0.013	0.0185	0.018
Onchocerca volvulus		0.1544	0.3068	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0416	0.0768	0.0768
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0091	0.0105	0.0134
Loa Loa (eye worm)	TK/INSR protein kinase	0.0063	0.0048	0.0043
Onchocerca volvulus		0.1015	0.1988	0.6357
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0211	0.0349	0.0446
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0197	0.032	0.0315
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0768	0.0764
Echinococcus multilocularis	integrin alpha ps	0.0539	0.1018	0.1303
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0575	0.1092	0.1398
Loa Loa (eye worm)	TK protein kinase	0.0211	0.0349	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0045	0.004
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Giardia lamblia	High cysteine protein	0.0146	0.0216	0.5
Echinococcus multilocularis	insulin receptor	0.0063	0.0048	0.0061
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0197	0.032	0.032
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0575	0.1092	0.1092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0291	0.0512	0.0507
Schistosoma mansoni	amine GPCR	0.0575	0.1092	0.1174
Schistosoma mansoni	hypothetical protein	0.0575	0.1092	0.1174
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus multilocularis	voltage dependent calcium channel	0.0128	0.018	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0575	0.1092	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	serine-type protease inhibitor	0.4602	0.9302	1
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.052	0.0979	0.1252
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0232	0.0393	0.0503
Schistosoma mansoni	voltage-gated potassium channel	0.052	0.0979	0.1052
Onchocerca volvulus		0.0416	0.0768	0.2239
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Brugia malayi	EGF-like domain containing protein	0.0146	0.0216	0.0216
Echinococcus granulosus	epidermal growth factor receptor	0.0164	0.0253	0.0324
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0575	0.1092	0.1174
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0232	0.0393	0.0503
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Echinococcus multilocularis	G protein coupled receptor 139	0.1501	0.2981	0.3815
Echinococcus multilocularis	NCK adaptor protein	0.0044	0.0008	0.0011
Onchocerca volvulus		0.0178	0.0281	0.0596
Schistosoma mansoni	hypothetical protein	0.0227	0.0381	0.041
Echinococcus multilocularis	integrin alpha 3	0.0809	0.1569	0.2008
Loa Loa (eye worm)	calcium channel	0.0128	0.018	0.0175
Trichomonas vaginalis	teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative	0.0146	0.0216	0.5
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0485	0.0909	0.0909
Schistosoma mansoni	tyrosine kinase	0.0232	0.0393	0.0422
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0211	0.0349	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	glycine receptor subunit beta	0.0416	0.0768	0.0983
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Brugia malayi	Integrin alpha pat-2 precursor	0.109	0.2141	0.2141
Echinococcus granulosus	neuropeptide Y receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0197	0.032	0.0727
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0197	0.032	0.032
Onchocerca volvulus		0.0182	0.0291	0.0628
Schistosoma mansoni	integrin beta subunit	0.3072	0.6184	0.6648
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0232	0.0393	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0197	0.032	0.0315
Echinococcus multilocularis	g-protein coupled receptor	0.0575	0.1092	0.1398
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0575	0.1092	0.1087
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0045	0.001	0.0013
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Echinococcus granulosus	biogenic amine 5HT receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	nAChR subunit	0.0197	0.032	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0008	0.0003
Loa Loa (eye worm)	PAN domain-containing protein	0.0178	0.0281	0.0276
Brugia malayi	EGF-like domain containing protein	0.0146	0.0216	0.0216
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0048	0.0048
Onchocerca volvulus		0.0227	0.0381	0.0933
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0416	0.0768	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0216	0.0211
Loa Loa (eye worm)	trypsin family protein	0.0227	0.0381	0.0376
Brugia malayi	hypothetical protein	0.0575	0.1092	0.1092
Echinococcus multilocularis	neuropeptide receptor	0.0575	0.1092	0.1398
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0011
Schistosoma mansoni	integrin alpha	0.109	0.2141	0.2301
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0291	0.0512	0.0507
Entamoeba histolytica	hypothetical protein	0.022	0.0367	1
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus granulosus	tyrosine kinase	0.0108	0.0139	0.0178
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2146	0.4296	0.5498
Schistosoma mansoni	cercarial elastase (S01 family)	0.0227	0.0381	0.041
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Echinococcus multilocularis	transmembrane protease serine 3	0.0227	0.0381	0.0488
Onchocerca volvulus		0.0575	0.1092	0.3332
Schistosoma mansoni	integrin alpha-ps	0.0281	0.0491	0.0528
Trypanosoma cruzi	hypothetical protein, conserved	0.0317	0.0565	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0178	0.0281	0.0276
Echinococcus multilocularis	fibrillin 1	0.0146	0.0216	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0416	0.0768	0.0826
Echinococcus multilocularis	g protein coupled receptor	0.0575	0.1092	0.1398
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0416	0.0768	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0105	0.01
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0381	0.041
Onchocerca volvulus		0.0178	0.0281	0.0596
Echinococcus granulosus	transmembrane protease serine 3	0.0227	0.0381	0.0488
Echinococcus multilocularis	neuropeptide Y receptor	0.0575	0.1092	0.1398
Onchocerca volvulus		0.0575	0.1092	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1092	0.1087
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0197	0.032	0.032
Toxoplasma gondii	PAN domain-containing protein	0.0178	0.0281	0.0737
Schistosoma mansoni	voltage-gated potassium channel	0.052	0.0979	0.1052

Activities

Activity type	Activity value	Assay description	Source	Reference
FC (binding)	= 1.05	Inhibition of recombinant 6-His-tagged SLAM associated protein SH2 domain (unknown origin) expressed in Escherichia coli BL21(DE3) binding to biotinyl-KKSLTIpYAQVQK-NH2 attached to NeutrAvidin-coated plates using p-nitrophenyl phosphate as substrate at 10 uM after 1 hr relative to control	ChEMBL.	23470190
Inhibition (binding)		Inhibition of recombinant 6-His-tagged SLAM associated protein SH2 domain (unknown origin) expressed in Escherichia coli BL21(DE3) binding to biotinyl-KKSLTIpYAQVQK-NH2 attached to NeutrAvidin-coated plates using p-nitrophenyl phosphate as substrate at 100 uM after 1 hr	ChEMBL.	23470190

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2321928

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1729321