Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Homo sapiens | sirtuin 3 | Starlite/ChEMBL | References |
Homo sapiens | sirtuin 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Trypanosoma brucei | SIR2-like protein 4, putative | sirtuin 3 | 257 aa | 247 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0191 | 0.5717 | 0.5717 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0191 | 0.5717 | 0.5717 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0191 | 0.5717 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3121 | 0.3121 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0191 | 0.5717 | 0.5717 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0191 | 0.5717 | 0.5717 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0191 | 0.5717 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.5717 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.5857 | 0.5857 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0191 | 0.5717 | 0.5717 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0191 | 0.5717 | 0.5717 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0191 | 0.5717 | 0.5717 |
Brugia malayi | ecdysteroid receptor | 0.0194 | 0.5857 | 0.5857 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0194 | 0.5857 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0048 uM | Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrate addition measured after 30 mins by mass spectrophotometric analysis | ChEMBL. | 23570514 |
IC50 (binding) | = 0.023 uM | Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after 30 mins by mass spectrophotometric analysis | ChEMBL. | 23570514 |
IC50 (binding) | = 0.031 uM | Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after 30 mins by mass spectrophotometric analysis | ChEMBL. | 23570514 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.