Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Candida glabrata CBS 138 | Carbonic anhydrase | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | Carbonic anhydrase | 219 aa | 199 aa | 25.6 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.2135 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.446 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 2.139 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 3.429 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 3.679 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 13.9 nM | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 135 nM | Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.