Detailed information for compound 1731728

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.299 | Formula: C15H9F7N2OS
  • H donors: 2 H acceptors: 1 LogP: 5.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)C(F)(F)F)F)Nc1ccc(cc1)SC(F)(F)F
  • InChi: 1S/C15H9F7N2OS/c16-12-6-3-9(7-11(12)14(17,18)19)24-13(25)23-8-1-4-10(5-2-8)26-15(20,21)22/h1-7H,(H2,23,24,25)
  • InChiKey: UKELNQDMNMPGST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0262 0.3502
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0248 0.0282
Echinococcus granulosus dna polymerase kappa 0.0021 0.0132 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0434 0.1855
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0068 0.002
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.019 0.3626 0.3595
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0068 0.0289
Plasmodium falciparum glutathione reductase 0.005 0.0749 0.0705
Trypanosoma brucei glucose transporter 2A 0.0036 0.0459 0.6123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0449 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.045 0.0617
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0248 0.5182
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.2132 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0166 0.0516
Plasmodium vivax CDK-related protein kinase 6, putative 0.0498 1 1
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0248 0.0308
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0132 0.1763
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0132 0.1205
Plasmodium falciparum hexose transporter 0.0117 0.2132 0.2094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.235 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0068 0.002
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0048 0.0199
Plasmodium vivax hexose transporter 0.0117 0.2132 0.2094
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0749 0.0987
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0132 0.0405
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0068 0.1012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0068 0.0289
Leishmania major DNA polymerase kappa, putative 0.0021 0.0132 0.1205
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0068 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0054 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.235 1
Leishmania major glucose transporter, lmgt1 0.0036 0.0459 0.586
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.045 0.0404
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0132 0.0405
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0749 0.0987
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0132 0.4218
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0403 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Brugia malayi Thioredoxin reductase 0.005 0.0749 0.3366
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0248 0.0374
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0434 0.9526
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0132 0.0283
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0449 0.2088
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0459 0.1973
Loa Loa (eye worm) hypothetical protein 0.0036 0.0449 0.2088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0248 0.2855
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0132 0.1205
Trypanosoma cruzi hexose transporter, putative 0.002 0.0118 0.1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0555 0.7229
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0132 0.1763
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0248 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0459 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0459 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0459 0.6123
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0132 0.1763
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Schistosoma mansoni hypothetical protein 0.0117 0.2132 0.6985
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0054 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0068 0.0289
Schistosoma mansoni protein kinase 0.0036 0.0449 0.1346
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0248 0.2855
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0434 0.1296
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Echinococcus multilocularis General substrate transporter 0.0101 0.1791 0.2452
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0132 0.0596
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0068 0.0289
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0434 0.1855
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0449 0.1927
Echinococcus granulosus tumor protein p63 0.036 0.7157 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0248 0.0671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0054 0.001
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.045 0.0404
Brugia malayi hypothetical protein 0.0027 0.0262 0.103
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Leishmania major DNA polymerase eta, putative 0.0021 0.0132 0.1205
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0434 0.1227
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0459 0.6123
Trypanosoma brucei sugar transporter, putative 0.0016 0.0048 0.0635
Plasmodium falciparum protein kinase 7 0.0331 0.6559 0.6542
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.045 0.0404
Loa Loa (eye worm) sugar transporter 0.0117 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0596
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0023
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.2132 0.2932
Entamoeba histolytica hypothetical protein 0.0026 0.0248 0.3652
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0262 0.0216
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.235 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0132 0.2186
Loa Loa (eye worm) hypothetical protein 0.0036 0.0458 0.2129
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0749 0.3047
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.2085 0.8847
Echinococcus granulosus General substrate transporter 0.0101 0.1791 0.2452
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0248 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0248 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.2085 0.8847
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0054 0.0231
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0068 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0434 0.0544
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0248 0.0961
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0458 0.1969
Toxoplasma gondii protein kinase, putative 0.0331 0.6559 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0132 0.1205
Loa Loa (eye worm) hypothetical protein 0.0053 0.0806 0.3764
Brugia malayi glutathione reductase 0.005 0.0749 0.3366
Brugia malayi Cam kinase protein 1 0.0036 0.0449 0.1927
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.2132 0.3201
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0068 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.1375
Plasmodium falciparum thioredoxin reductase 0.0017 0.0068 0.002
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0048 0.0635
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.045 0.0404
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0132 0.0367
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0248 0.0961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0054 0.001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0449 0.2088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0023
Leishmania major trypanothione reductase 0.005 0.0749 1
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0068 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.1141
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0749 0.0705
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0068 0.0088
Loa Loa (eye worm) sugar transporter 0.0016 0.0048 0.0199
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0132 0.1205
Plasmodium falciparum glutathione reductase 0.0017 0.0068 0.002
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0806 0.3638
Plasmodium falciparum thioredoxin reductase 0.005 0.0749 0.0705
Leishmania major glucose transporter, lmgt3 0.0036 0.0459 0.586
Toxoplasma gondii thioredoxin reductase 0.005 0.0749 0.1077
Echinococcus multilocularis dna polymerase eta 0.0021 0.0132 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0132 0.1205
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0459 0.1973
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0068 0.1012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0262 0.1209
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0434 0.1855
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0068 0.0097
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0248 0.3309
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0248 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0459 0.586
Schistosoma mansoni hypothetical protein 0.0036 0.0458 0.1375
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Trypanosoma brucei trypanothione reductase 0.005 0.0749 1
Trypanosoma brucei unspecified product 0.0021 0.0132 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0459 0.6123
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0806 0.3638
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0068 0.0906
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0068 0.0097
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.2085 0.8785
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0459 0.586
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0068 0.0524
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0132 0.1763
Echinococcus granulosus dna polymerase eta 0.0021 0.0132 0.0119
Treponema pallidum NADH oxidase 0.0017 0.0068 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0262 0.3061
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0555 0.7405
Brugia malayi hypothetical protein 0.0017 0.0065 0.0085
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0797 0.3723
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0068 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0449 0.1346
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.045 0.0617
Brugia malayi Sugar transporter family protein 0.0117 0.2132 1
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0248 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Entamoeba histolytica protein kinase, putative 0.0036 0.0449 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0132 0.0405
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0403 0.05
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0262 0.0216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0132 0.4218
Leishmania major protein kinase, putative 0.0036 0.0449 0.5725
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0181 0.0641
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.045 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0434 0.2017
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0434 0.1296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0132 0.0119
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0023
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0459 0.586
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0449 0.1927
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0262 0.3061
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0132 0.0283
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0459 0.1973
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Trypanosoma cruzi hexose transporter 0.0036 0.0459 0.586
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0068 0.0906
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0231
Leishmania major hypothetical protein, conserved 0.0027 0.0262 0.3061
Schistosoma mansoni glucose transport protein 0.0117 0.2132 0.6985
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0459 0.1973
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0555 0.7229
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0459 0.586
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0555 0.051
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0262 0.033
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0068 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0434 0.2017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0132 0.0119
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0555 0.0779
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0068 0.0289
Trypanosoma brucei glucose transporter, putative 0.0036 0.0459 0.6123
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0132 0.0405
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0068
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0068 0.1012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.2085 0.8847
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0434 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0029
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0449 0.5996
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0555 0.051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0132 0.1205
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0132 0.1763
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0797 0.2512
Plasmodium vivax glutathione reductase, putative 0.005 0.0749 0.0705
Loa Loa (eye worm) glutathione reductase 0.005 0.0749 0.3498
Plasmodium falciparum mitogen-activated protein kinase 2 0.019 0.3626 0.3595
Echinococcus multilocularis tumor protein p63 0.036 0.7157 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0054 0.0033
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0132 0.0119
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.2085 0.8847
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0054 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.235 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0806 0.3764
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0555 0.7229
Mycobacterium tuberculosis Probable reductase 0.0115 0.2085 0.8847
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0555 0.7229
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.045 0.0617
Schistosoma mansoni protein kinase 0.0036 0.0449 0.1346
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.045 0.0404
Entamoeba histolytica protein kinase, putative 0.0036 0.0449 1
Leishmania major glucose transporter, lmgt2 0.0036 0.0459 0.586
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.2132 0.2932
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0459 0.1973
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.045 0.0404
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.045 0.0404
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.2085 0.8847
Schistosoma mansoni DNA polymerase eta 0.0021 0.0132 0.0283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0132 0.0367
Echinococcus multilocularis GPCR, family 2 0.0017 0.0054 0.001
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0434 0.0544
Schistosoma mansoni protein kinase 0.0036 0.0449 0.1346
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.045 0.0404
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0068 0.0906
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0166 0.0516
Echinococcus granulosus GPCR family 2 0.0017 0.0054 0.001
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0048 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199
Schistosoma mansoni glucose transport protein 0.0117 0.2132 0.6985
Schistosoma mansoni glucose transport protein 0.0117 0.2132 0.6985
Trypanosoma brucei glucose transporter 1E 0.0036 0.0459 0.6123
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0749 0.3498
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0262 0.0216
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0449 0.0565
Onchocerca volvulus 0.0053 0.0797 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.019 0.3626 0.5495
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0068 0.002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0068 0.0289
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0248 0.0201
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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