Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Candida glabrata CBS 138 | Carbonic anhydrase | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | Carbonic anhydrase | 219 aa | 199 aa | 25.6 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.2135 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.612 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 1.682 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 2.253 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 2.472 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 6.7 nM | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Ki (binding) | = 72 nM | Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 23511020 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.