Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.3296 | 0.3296 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.004 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.3296 | 0.3296 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.3296 | 0.3296 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.004 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.6468 | 0.5975 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.004 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.6468 | 0.5975 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3172 | 0.2219 |
Schistosoma mansoni | coup transcription factor | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.004 | 0.1225 | 0.1225 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 1 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.3296 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.6468 | 0.5975 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.004 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.6468 | 0.5975 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.3296 | 0.3296 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.004 | 0.1225 | 0.1225 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.1225 | 0.1225 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.6468 | 0.5975 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.6468 | 0.5975 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.1225 | 0.1225 |
Onchocerca volvulus | 0.0056 | 0.3172 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.6704 | 0.6244 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.114 | Inhibition of Homo sapiens (human) endothelin converting enzyme-1 | ChEMBL. | No reference |
IC50 (binding) | = 77 nM | In vitro inhibition of Endothelin-converting enzyme 1. | ChEMBL. | 12372501 |
IC50 (binding) | = 77 nM | In vitro inhibition of Endothelin-converting enzyme 1. | ChEMBL. | 12372501 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.