Detailed information for compound 1734584

Basic information

Technical information
  • TDR Targets ID: 1734584
  • Name: (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-cy clopentyl-N-[5-(3-methoxyprop-1-ynyl)pyrazin- 2-yl]propanamide
  • MW: 475.988 | Formula: C23H26ClN3O4S
  • H donors: 1 H acceptors: 5 LogP: 3.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC#Cc1cnc(cn1)NC(=O)[C@@H](c1ccc(c(c1)Cl)S(=O)(=O)C)CC1CCCC1
  • InChi: 1S/C23H26ClN3O4S/c1-31-11-5-8-18-14-26-22(15-25-18)27-23(28)19(12-16-6-3-4-7-16)17-9-10-21(20(24)13-17)32(2,29)30/h9-10,13-16,19H,3-4,6-7,11-12H2,1-2H3,(H,26,27,28)/t19-/m1/s1
  • InChiKey: MLELNNISKJTUDF-LJQANCHMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-(3-chloro-4-methylsulfonyl-phenyl)-3-cyclopentyl-N-[5-(3-methoxyprop-1-ynyl)pyrazin-2-yl]propanamide
  • (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-N-[5-(3-methoxyprop-1-ynyl)-2-pyrazinyl]propanamide
  • (2R)-2-(3-chloro-4-mesyl-phenyl)-3-cyclopentyl-N-[5-(3-methoxyprop-1-ynyl)pyrazin-2-yl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Schistosoma mansoni protein tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus cpg binding protein 0.0034 0.145 0.1305
Echinococcus granulosus tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Echinococcus multilocularis protein KINase family member (kin 25) 0.0052 0.2373 0.2244
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Trypanosoma brucei protein kinase, putative 0.0052 0.2373 1
Echinococcus multilocularis FL cytokine receptor 0.0052 0.2373 0.2244
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Brugia malayi Variant SH3 domain containing protein 0.0077 0.3624 0.5641
Echinococcus granulosus tyrosine protein kinase Blk 0.013 0.6225 0.6161
Echinococcus granulosus activin receptor type 0.0052 0.2373 0.2244
Echinococcus multilocularis tensin 0.0077 0.3624 0.3515
Echinococcus multilocularis hedgehog 0.0206 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.2373 0.354
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0263 0.0098
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Echinococcus granulosus kinase suppressor of Ras 1 0.0052 0.2373 0.2244
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.013 0.6225 0.6161
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.2373 0.3286
Echinococcus multilocularis protein kinase 0.0052 0.2373 0.2244
Echinococcus granulosus growth factor receptor bound protein 2 0.0077 0.3624 0.3515
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0077 0.3624 0.4654
Echinococcus granulosus tyrosine protein kinase shark 0.013 0.6225 0.6161
Leishmania major protein kinase, putative 0.0052 0.2373 1
Schistosoma mansoni hypothetical protein 0.0077 0.3624 0.5017
Brugia malayi SH2 domain containing protein 0.013 0.6225 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Giardia lamblia Kinase, NEK 0.0052 0.2373 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.1359 0.1847
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.2373 0.3286
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0077 0.3624 0.3515
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) serine/threonine protein kinase 0.0052 0.2373 0.354
Onchocerca volvulus 0.0052 0.2373 0.2085
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Toxoplasma gondii STE kinase 0.0052 0.2373 0.794
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Onchocerca volvulus 0.0052 0.2373 0.2085
Echinococcus granulosus tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Echinococcus multilocularis tyrosine protein kinase Srms 0.013 0.6225 0.6161
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis tyrosine protein kinase ABL1 0.013 0.6225 0.6161
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0052 0.2373 0.2885
Echinococcus granulosus raf serine:threonine protein kinase 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.2373 0.3547
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Echinococcus granulosus receptor type guanylyl cyclase 0.0052 0.2373 0.2244
Loa Loa (eye worm) TK/EGFR protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica hypothetical protein 0.004 0.176 0.1753
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0052 0.2373 0.2244
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.2373 0.2244
Schistosoma mansoni serine/threonine RGC 0.0052 0.2373 0.3286
Echinococcus multilocularis tyrosine protein kinase HCK 0.0052 0.2373 0.2244
Onchocerca volvulus 0.0077 0.3624 0.4654
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis tyrosine protein kinase shark 0.013 0.6225 0.6161
Brugia malayi hypothetical protein 0.0077 0.3624 0.5641
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Echinococcus granulosus ephrin type A receptor 4 A 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus tyrosine protein kinase Fps85D 0.013 0.6225 0.6161
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0052 0.2373 1
Schistosoma mansoni ephrin receptor 0.0052 0.2373 0.3286
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0812 0.0656
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0052 0.2373 0.3547
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Brugia malayi Protein kinase domain containing protein 0.013 0.6225 1
Brugia malayi Raf kinase 0.0052 0.2373 0.3547
Echinococcus granulosus insulin receptor 0.0052 0.2373 0.2244
Schistosoma mansoni tensin-related 0.0077 0.3624 0.5017
Schistosoma mansoni suppressor of cytokine signaling 0.0077 0.3624 0.5017
Schistosoma mansoni ap endonuclease 0.0021 0.0812 0.1124
Echinococcus multilocularis insulin receptor 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0077 0.3624 0.3515
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0077 0.3624 0.3515
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Brugia malayi Variant SH3 domain containing protein 0.0077 0.3624 0.5641
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Brugia malayi Protein kinase domain containing protein 0.013 0.6225 1
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0077 0.3624 0.5637
Toxoplasma gondii protein kinase 0.0052 0.2373 0.794
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.2373 0.354
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.2373 0.2244
Brugia malayi Sex muscle abnormal protein 5 0.0077 0.3624 0.5641
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Brugia malayi ephrin receptor 1 precursor 0.0052 0.2373 0.3547
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Brugia malayi hypothetical protein 0.0052 0.2373 0.3547
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0052 0.2373 0.794
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0077 0.3624 0.5637
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.2373 0.3286
Echinococcus granulosus integrin linked protein kinase 0.0052 0.2373 0.2244
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis epidermal growth factor receptor 0.0052 0.2373 0.2244
Echinococcus multilocularis c src tyrosine kinase 0.013 0.6225 0.6161
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0052 0.2373 0.354
Brugia malayi Protein kinase domain containing protein 0.013 0.6225 1
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Onchocerca volvulus 0.0077 0.3624 0.4654
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0052 0.2373 0.2244
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.2373 0.2244
Echinococcus multilocularis tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Loa Loa (eye worm) STAT protein 0.0077 0.3624 0.5637
Entamoeba histolytica protein kinase, putative 0.0077 0.3624 0.5195
Loa Loa (eye worm) TK/FAK protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Plasmodium vivax tyrosine kinase-like protein, putative 0.0052 0.2373 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0052 0.2373 0.354
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.2373 0.3286
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0077 0.3624 0.3515
Loa Loa (eye worm) SH2 domain-containing protein 0.0077 0.3624 0.5637
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.2373 0.2244
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis receptor type guanylyl cyclase 0.0052 0.2373 0.2244
Echinococcus granulosus tyrosine protein kinase ABL1 0.013 0.6225 0.6161
Brugia malayi integrin-linked kinase 0.0052 0.2373 0.3547
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0077 0.3624 0.3515
Schistosoma mansoni tensin 0.0077 0.3624 0.5017
Schistosoma mansoni shc transforming protein 0.0077 0.3624 0.5017
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.2373 0.2885
Brugia malayi SRC-1 0.013 0.6225 1
Echinococcus multilocularis tyrosine protein kinase 0.0052 0.2373 0.2244
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/RYK protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Brugia malayi STAT protein, DNA binding domain containing protein 0.0077 0.3624 0.5641
Echinococcus multilocularis tyrosine protein kinase Abl 0.013 0.6225 0.6161
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.2373 0.3286
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0812 0.092
Brugia malayi tRNA modification GTPase TrmE family protein 0.0077 0.3624 0.5641
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica ankyrin repeat protein 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.2373 0.2885
Trypanosoma cruzi protein kinase, putative 0.0052 0.2373 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0052 0.2373 0.354
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.2373 0.2244
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Echinococcus granulosus signal transduction protein lnk realted 0.0077 0.3624 0.3515
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0077 0.3624 0.3515
Brugia malayi Guanylyl cyclase protein 23 0.0052 0.2373 0.3547
Echinococcus multilocularis SH2 motif 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Echinococcus multilocularis epidermal growth factor receptor 0.0052 0.2373 0.2244
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0812 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0052 0.2373 0.794
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0077 0.3624 0.5637
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Schistosoma mansoni cpg binding protein 0.0032 0.1359 0.1882
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0052 0.2373 0.3286
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.013 0.6225 0.6161
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Echinococcus granulosus expressed conserved protein 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK/ABL protein kinase 0.013 0.6225 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0052 0.2373 0.354
Leishmania major protein kinase, putative 0.0052 0.2373 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0052 0.2373 0.2085
Brugia malayi Protein kinase domain containing protein 0.013 0.6225 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0077 0.3624 0.3515
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni growth factor receptor-bound protein 0.0077 0.3624 0.5017
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0077 0.3624 0.3515
Schistosoma mansoni cpg binding protein 0.0034 0.145 0.2007
Onchocerca volvulus 0.0052 0.2373 0.2085
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Brugia malayi hypothetical protein 0.013 0.6225 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0812 0.5
Schistosoma mansoni hypothetical protein 0.0077 0.3624 0.5017
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0167 0.0231
Loa Loa (eye worm) SH2 domain-containing protein 0.0077 0.3624 0.5637
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.176 0.1621
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Schistosoma mansoni tyrosine protein kinase 0.0052 0.2373 0.3286
Brugia malayi Variant SH3 domain containing protein 0.0077 0.3624 0.5641
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0052 0.2373 0.794
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Echinococcus granulosus N chimaerin 0.0077 0.3624 0.3515
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Onchocerca volvulus 0.013 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0077 0.3624 0.5637
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Brugia malayi protein-tyrosine kinase 0.013 0.6225 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0052 0.2373 0.3547
Onchocerca volvulus 0.0052 0.2373 0.2085
Entamoeba histolytica receptor protein kinase, putative 0.0052 0.2373 0.2885
Giardia lamblia Kinase, NEK 0.0052 0.2373 1
Brugia malayi C-terminal src kinase protein 1 0.0052 0.2373 0.3547
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0052 0.2373 0.2885
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Onchocerca volvulus 0.0077 0.3624 0.4654
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0812 0.3032
Brugia malayi Hint module family protein 0.0056 0.255 0.3843
Loa Loa (eye worm) SRC-1 0.013 0.6225 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.2373 0.3547
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Plasmodium vivax tyrosine kinase-like protein, putative 0.0052 0.2373 1
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.2373 0.2244
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.1359 0.1838
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis heat shock protein 70 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0812 0.0656
Echinococcus multilocularis SH2 motif 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Echinococcus granulosus SH2 domain containing protein 7 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Brugia malayi Tensin 0.0077 0.3624 0.5641
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Schistosoma mansoni SH2A 0.0077 0.3624 0.5017
Entamoeba histolytica SH2-protein kinase domain containing protein 0.013 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Echinococcus multilocularis tyrosine kinase 0.0052 0.2373 0.2244
Echinococcus granulosus natriuretic peptide receptor 1 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Echinococcus granulosus tensin 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0812 0.0929
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0052 0.2373 0.3286
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.013 0.6225 0.6161
Onchocerca volvulus 0.0052 0.2373 0.2085
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0077 0.3624 0.3515
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.2373 0.3286
Onchocerca volvulus 0.0052 0.2373 0.2085
Echinococcus granulosus tyrosine protein kinase Srms 0.013 0.6225 0.6161
Echinococcus granulosus tyrosine kinase 0.013 0.6225 0.6161
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Echinococcus multilocularis tensin 0.0077 0.3624 0.3515
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0052 0.2373 0.354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.176 0.1621
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni transcription factor LCR-F1 0.004 0.176 0.2437
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni adapter molecule crk 0.0077 0.3624 0.5017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0263 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.3138 0.4345
Echinococcus granulosus SH2 motif 0.0077 0.3624 0.3515
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0052 0.2373 0.2085
Schistosoma mansoni signal transduction protein lnk-related 0.0077 0.3624 0.5017
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica SH2 domain containing protein 0.0077 0.3624 0.5195
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Onchocerca volvulus 0.013 0.6225 1
Plasmodium falciparum tyrosine kinase-like protein 0.0052 0.2373 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Schistosoma mansoni GTPase activating protein 0.0077 0.3624 0.5017
Onchocerca volvulus 0.0052 0.2373 0.2085
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.2373 0.2244
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0077 0.3624 0.5017
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.2373 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis growth factor receptor bound protein 2 0.0077 0.3624 0.3515
Echinococcus multilocularis tyrosine protein kinase pr2 0.0052 0.2373 0.2244
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Brugia malayi SH2 domain containing protein 0.013 0.6225 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.2373 0.3547
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0077 0.3624 0.3515
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0077 0.3624 0.5637
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.2373 0.354
Loa Loa (eye worm) protein kinase domain-containing protein 0.0052 0.2373 0.354
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0052 0.2373 0.2244
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.2373 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.2373 0.2244
Brugia malayi Tyrosine-protein kinase PR2 0.0052 0.2373 0.3547
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.013 0.6225 0.6161
Onchocerca volvulus 0.0052 0.2373 0.2085
Echinococcus multilocularis transfer RNA-Thr 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Trypanosoma brucei Pseudokinase, putative 0.0052 0.2373 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Echinococcus granulosus tyrosine protein kinase Src42A 0.013 0.6225 0.6161
Entamoeba histolytica cysteine surface protein, putative 0.0052 0.2373 0.2885
Echinococcus multilocularis kinase suppressor of Ras 1 0.0052 0.2373 0.2244
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.013 0.6225 0.8619
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis protein kinase 0.0052 0.2373 0.2244
Echinococcus granulosus tyrosine kinase 0.013 0.6225 0.6161
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.2373 0.2244
Trichomonas vaginalis TK family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Loa Loa (eye worm) TK/ACK protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Echinococcus multilocularis activin receptor type 0.0052 0.2373 0.2244
Schistosoma mansoni tensin-related 0.0077 0.3624 0.5017
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0052 0.2373 0.354
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0812 0.5
Onchocerca volvulus 0.0077 0.3624 0.4654
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Schistosoma mansoni cpg binding protein 0.0034 0.145 0.2007
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni growth factor receptor-bound protein 0.0077 0.3624 0.5017
Echinococcus granulosus epidermal growth factor receptor 0.0052 0.2373 0.2244
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0052 0.2373 0.354
Brugia malayi Variant SH3 domain containing protein 0.0077 0.3624 0.5641
Brugia malayi cytokine inducible SH2-containing protein 5 0.0077 0.3624 0.5641
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/INSR protein kinase 0.0052 0.2373 0.354
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni hypothetical protein 0.0052 0.2373 0.3286
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0077 0.3624 0.5017
Giardia lamblia Kinase 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.255 0.3836
Echinococcus granulosus NCK adaptor protein 0.0077 0.3624 0.3515
Loa Loa (eye worm) TK/Met protein kinase 0.0052 0.2373 0.354
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Echinococcus multilocularis raf serine:threonine protein kinase 0.0052 0.2373 0.2244
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.2373 0.354
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis protein kinase atn1, putative 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Loa Loa (eye worm) hypothetical protein 0.013 0.6225 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus protein kinase 0.0052 0.2373 0.2244
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Echinococcus multilocularis tyrosine protein kinase Fgr 0.013 0.6225 0.6161
Echinococcus granulosus SH2 motif 0.0077 0.3624 0.3515
Onchocerca volvulus 0.0077 0.3624 0.4654
Echinococcus granulosus epidermal growth factor receptor 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Echinococcus granulosus tyrosine protein kinase 0.0052 0.2373 0.2244
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Plasmodium falciparum protein kinase, putative 0.0052 0.2373 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0077 0.3624 0.5017
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Entamoeba histolytica hypothetical protein 0.004 0.176 0.1753
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Onchocerca volvulus 0.013 0.6225 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.2373 0.3286
Brugia malayi SH2 domain containing protein 0.0077 0.3624 0.5641
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0077 0.3624 0.3515
Brugia malayi hypothetical protein 0.004 0.176 0.2519
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Onchocerca volvulus 0.0077 0.3624 0.4654
Onchocerca volvulus 0.013 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Schistosoma mansoni ap endonuclease 0.0021 0.0812 0.1124
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Plasmodium vivax protein kinase, putative 0.0052 0.2373 1
Trypanosoma cruzi protein kinase, putative 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.013 0.6225 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.013 0.6225 0.6161
Echinococcus multilocularis N chimaerin 0.0077 0.3624 0.3515
Brugia malayi Hint module family protein 0.0056 0.255 0.3843
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0052 0.2373 0.2244
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0077 0.3624 0.4654
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Echinococcus multilocularis tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Echinococcus multilocularis tyrosine protein kinase Src64B 0.013 0.6225 0.6161
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.2373 0.2885
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.2373 0.3547
Schistosoma mansoni vav2 0.0077 0.3624 0.5017
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0052 0.2373 0.354
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis STE family protein kinase 0.0052 0.2373 1
Brugia malayi hypothetical protein 0.0052 0.2373 0.3547
Echinococcus granulosus tyrosine protein kinase pr2 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.2373 0.3286
Echinococcus multilocularis SHC transforming protein 3 0.0077 0.3624 0.3515
Echinococcus granulosus tyrosine protein kinase Src64B 0.013 0.6225 0.6161
Echinococcus multilocularis signal transduction protein lnk realted 0.0077 0.3624 0.3515
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0077 0.3624 0.3515
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.2373 0.2244
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0052 0.2373 0.794
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0052 0.2373 0.2244
Plasmodium falciparum protein kinase, putative 0.0052 0.2373 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica hypothetical protein 0.004 0.176 0.1753
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Echinococcus granulosus SHC transforming protein 3 0.0077 0.3624 0.3515
Echinococcus multilocularis tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0077 0.3624 0.5641
Echinococcus granulosus tyrosine protein kinase Lyn 0.013 0.6225 0.6161
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Echinococcus multilocularis activated cdc42 kinase 1 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Trichomonas vaginalis protein tyrosine kinase, putative 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/FER protein kinase 0.013 0.6225 1
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.013 0.6225 0.6161
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0077 0.3624 0.3515
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.2373 0.2244
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Echinococcus multilocularis NCK adaptor protein 0.0077 0.3624 0.3515
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis tyrosine protein kinase Blk 0.013 0.6225 0.6161
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Schistosoma mansoni tensin 0.0077 0.3624 0.5017
Entamoeba histolytica receptor protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Entamoeba histolytica hypothetical protein, conserved 0.0052 0.2373 0.2885
Echinococcus granulosus tyrosine protein kinase HCK 0.0052 0.2373 0.2244
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Echinococcus multilocularis 0.0077 0.3624 0.3515
Onchocerca volvulus Tyrosine kinase homolog 0.0052 0.2373 0.2085
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0052 0.2373 0.354
Trichomonas vaginalis AGC family protein kinase 0.0052 0.2373 1
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0077 0.3624 0.3515
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0077 0.3624 0.5637
Echinococcus granulosus tyrosine kinase 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.6225 1
Entamoeba histolytica hypothetical protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.2373 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0077 0.3624 0.3515
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Echinococcus multilocularis integrin linked protein kinase 0.0052 0.2373 0.2244
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0052 0.2373 1
Plasmodium falciparum tyrosine kinase-like protein 0.0052 0.2373 1
Onchocerca volvulus 0.013 0.6225 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.2373 0.2244
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0077 0.3624 0.5195
Echinococcus multilocularis cpg binding protein 0.0034 0.145 0.1305
Echinococcus multilocularis protein tyrosine kinase 0.0052 0.2373 0.2244
Echinococcus granulosus tyrosine protein kinase Btk29A 0.013 0.6225 0.6161
Brugia malayi Protein kinase domain containing protein 0.0052 0.2373 0.3547
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni tensin 0.0077 0.3624 0.5017
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Schistosoma mansoni hypothetical protein 0.004 0.176 0.2437
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0077 0.3624 0.3515
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0052 0.2373 0.3547
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0812 0.3032
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Schistosoma mansoni hypothetical protein 0.015 0.7222 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0052 0.2373 0.2244
Loa Loa (eye worm) hypothetical protein 0.0056 0.255 0.3836
Loa Loa (eye worm) TK protein kinase 0.013 0.6225 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0052 0.2373 0.2244
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0077 0.3624 0.3515
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0077 0.3624 0.5017
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.2373 0.2244
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Leishmania major hypothetical protein, conserved 0.0052 0.2373 1
Loa Loa (eye worm) TK protein kinase 0.0052 0.2373 0.354
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0052 0.2373 0.2244
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0052 0.2373 1
Entamoeba histolytica hypothetical protein 0.004 0.176 0.1753
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.013 0.6225 0.6161
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0812 0.5
Schistosoma mansoni protein kinase 0.0052 0.2373 0.3286
Echinococcus granulosus SH2 domain containing adapter protein F 0.0077 0.3624 0.3515
Schistosoma mansoni nck2/grb4 0.0077 0.3624 0.5017
Onchocerca volvulus 0.0052 0.2373 0.2085
Entamoeba histolytica protein kinase, putative 0.0052 0.2373 0.2885
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.3624 0.5637
Entamoeba histolytica ankyrin repeat protein 0.0052 0.2373 0.2885
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Plasmodium falciparum protein kinase, putative 0.0052 0.2373 1
Schistosoma mansoni suppressor of cytokine signaling 0.0077 0.3624 0.5017
Echinococcus granulosus fibroblast growth factor receptor 4 0.0052 0.2373 0.2244
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2373 1
Echinococcus multilocularis tyrosine kinase 0.013 0.6225 0.6161
Onchocerca volvulus 0.013 0.6225 1
Echinococcus granulosus hypothetical protein 0.0077 0.3624 0.3515
Trichomonas vaginalis TKL family protein kinase 0.0052 0.2373 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.2373 0.2244
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0052 0.2373 0.2244
Loa Loa (eye worm) hypothetical protein 0.0052 0.2373 0.354
Loa Loa (eye worm) SH2 domain-containing protein 0.0077 0.3624 0.5637
Echinococcus multilocularis tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Brugia malayi Furin-like cysteine rich region family protein 0.0052 0.2373 0.3547
Schistosoma mansoni ephrin receptor 0.0052 0.2373 0.3286
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0052 0.2373 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.013 0.6225 0.8619
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.2779 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0052 0.2373 0.2244
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0052 0.2373 0.354
Giardia lamblia Protein 21.1 0.0052 0.2373 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.013 0.6225 0.6161
Echinococcus multilocularis SH2 motif 0.0077 0.3624 0.3515
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.2373 0.2244
Schistosoma mansoni tyrosine kinase 0.0052 0.2373 0.3286
Echinococcus granulosus protein tyrosine kinase 0.0052 0.2373 0.2244
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0077 0.3624 0.5017
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.2373 0.2885
Echinococcus granulosus suppressor of cytokine signaling 6 0.0077 0.3624 0.3515
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.2373 0.2885
Echinococcus granulosus tyrosine protein kinase Fyn 0.013 0.6225 0.6161
Echinococcus granulosus c src tyrosine kinase 0.013 0.6225 0.6161
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0052 0.2373 0.2244
Brugia malayi RhoGAP domain containing protein 0.0077 0.3624 0.5641
Trypanosoma brucei Flagellum attachment zone protein 20 0.0052 0.2373 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.2373 0.2244

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -49 % Antidiabetic activity in C57Bl/6J mouse assessed as change in blood glucose level at 50 mg/kg, po after 4 hrs relative to vehicle-treated control ChEMBL. 24900686
Activity (binding) = 0.14 uM Activation of glucokinase (unknown origin) using glucose as substrate assessed as stimulation concentration required to achieve 150% activity relative to control ChEMBL. 24900686
Inhibition (ADMET) = 45 % Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM incubated for 3 to 24 mins prior to substrate addition measured after 10 mins by LC-MS/MS analysis in presence of NADPH ChEMBL. 24900686
Inhibition (binding) = 53 % Inhibition of human ERG channel at 10 uM by patch clamp method ChEMBL. 24900686

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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