Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0123 | 0.0123 |
Echinococcus multilocularis | hexokinase type 2 | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0272 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0171 | 0.4604 | 0.4604 |
Trypanosoma brucei | hexokinase, putative | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0272 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0272 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0272 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0272 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0272 | 1 | 0.5 |
Onchocerca volvulus | 0.0272 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.0272 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0272 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0123 | 0.0123 |
Leishmania major | hexokinase, putative | 0.0272 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0272 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0272 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0171 | 0.4604 | 0.4604 |
Onchocerca volvulus | 0.0272 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0272 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.5396 | 0.5396 |
Loa Loa (eye worm) | hexokinase | 0.0272 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0272 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0087 | 0.0123 | 0.0123 |
Schistosoma mansoni | hexokinase | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0272 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0272 | 1 | 0.5 |
Onchocerca volvulus | 0.0272 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1750 nM | Inhibition of human ELOVL6 expressed in Pichia pastoris SND1168 | ChEMBL. | 19522500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.