TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.41 | Formula: C21H24O9
H donors: 3 H acceptors: 5 LogP: -0.54 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc2c1[C@@H](OC)[C@]13[C@](C2=O)(O1)[C@H](O)[C@H]([C@]([C@H]3O)(O)C(=O)[C@@H]1O[C@H]1C)C
InChi: 1S/C21H24O9/c1-8-14(22)20-15(23)10-6-5-7-11(27-3)12(10)17(28-4)21(20,30-20)18(25)19(8,26)16(24)13-9(2)29-13/h5-9,13-14,17-18,22,25-26H,1-4H3/t8-,9+,13-,14-,17-,18-,19+,20+,21+/m1/s1
InChiKey: WWNXYRCJJRRWAQ-UUYIBEJGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear receptor nhr-48	0.0194869	0.347342	0.347342
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Giardia lamblia	Cathepsin B precursor	0.0165782	0.260356	0.5
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0413107	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0218238	0.41723	0.355039
Entamoeba histolytica	cysteine proteinase, putative	0.0110966	0.0964258	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0413107	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0358196	0.835786	0.835786
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0110966	0.0964258	0.0964258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Trypanosoma cruzi	cysteine peptidase, putative	0.0110966	0.0964258	0.115372
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0413107	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0110966	0.0964258	1
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	conserved hypotetical protein	0.0194869	0.347342	0.347342
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0413107	1	1
Brugia malayi	ecdysone receptor	0.0194869	0.347342	0.347342
Brugia malayi	cathepsin B-like cysteine proteinase	0.0358196	0.835786	0.835786
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	hypothetical protein	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	hypothetical protein	0.0358196	0.835786	0.835786
Loa Loa (eye worm)	cysteine protease	0.0110966	0.0964258	0.0964258
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0218238	0.41723	0.41723
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Schistosoma mansoni	thyroid hormone receptor	0.0413107	1	1
Schistosoma mansoni	zinc finger protein	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0413107	1	1
Loa Loa (eye worm)	DR-78	0.0194869	0.347342	0.347342
Onchocerca volvulus		0.0413107	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165782	0.260356	0.260356
Echinococcus multilocularis	ecdysone induced protein 78C	0.0413107	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0194869	0.347342	0.277693
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0413107	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0194869	0.347342	0.347342
Brugia malayi	nuclear receptor NHR-88	0.0413107	1	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0194869	0.347342	0.347342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Plasmodium vivax	vivapain-2	0.0110966	0.0964258	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0194869	0.347342	0.347342
Schistosoma mansoni	thyroid hormone receptor	0.0413107	1	1
Schistosoma mansoni	nuclear receptor	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	hypothetical protein	0.0218238	0.41723	0.41723
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0218238	0.41723	0.41723
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0413107	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0218238	0.41723	0.41723
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Echinococcus multilocularis	FTZ F1 alpha	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0110966	0.0964258	0.370361
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0194869	0.347342	0.347342
Brugia malayi	orphan nuclear receptor NR2E1	0.0194869	0.347342	0.347342
Brugia malayi	nuclear hormone receptor	0.0413107	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0413107	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0413107	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0413107	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0194869	0.347342	0.347342
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0194869	0.347342	0.347342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Onchocerca volvulus	Cathepsin F homolog	0.0110966	0.0964258	0.0964258
Brugia malayi	Nuclear hormone receptor-like 1	0.0413107	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0413107	1	1
Brugia malayi	nuclear receptor NHR-67	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0165782	0.260356	1
Toxoplasma gondii	cathepsin B	0.0165782	0.260356	1
Loa Loa (eye worm)	steroid hormone receptor	0.0413107	1	1
Brugia malayi	steroid hormone receptor	0.0413107	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0110966	0.0964258	0.115372
Entamoeba histolytica	cysteine protease, putative	0.0110966	0.0964258	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0194869	0.347342	0.347342
Onchocerca volvulus	Cathepsin L homolog	0.0110966	0.0964258	0.0964258
Echinococcus granulosus	cathepsin l1	0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0413107	1	1
Brugia malayi	hypothetical protein	0.0194869	0.347342	0.347342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	photoreceptor-specific nuclear receptor	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Schistosoma mansoni	cathepsin F (C01 family)	0.0110966	0.0964258	0.0964258
Trypanosoma cruzi	cysteine peptidase, putative	0.0110966	0.0964258	0.115372
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Brugia malayi	nuclear receptor NHR-88	0.0194869	0.347342	0.347342
Echinococcus multilocularis	cathepsin b	0.0358196	0.835786	0.818261
Brugia malayi	ecdysteroid receptor	0.0413107	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0358196	0.835786	0.835786
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Brugia malayi	nuclear hormone receptor	0.0194869	0.347342	0.347342
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	nuclear receptor RXR	0.0218238	0.41723	0.41723
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0413107	1	1
Echinococcus multilocularis	cathepsin b	0.0358196	0.835786	0.818261
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Plasmodium vivax	vivapain-2	0.0110966	0.0964258	0.5
Schistosoma mansoni	coup transcription factor	0.0413107	1	1
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0413107	1	1
Brugia malayi	tailless protein	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0413107	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0194869	0.347342	0.277693
Schistosoma mansoni	nuclear hormone receptor	0.0413107	1	1
Echinococcus granulosus	cathepsin b	0.0358196	0.835786	0.835786
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Onchocerca volvulus		0.0194869	0.347342	0.347342
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0110966	0.0964258	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0413107	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0358196	0.835786	0.835786
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0194869	0.347342	0.277693
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0194869	0.347342	0.347342
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0165782	0.260356	1
Brugia malayi	hypothetical protein	0.0218238	0.41723	0.41723
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0413107	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0358196	0.835786	0.835786
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Loa Loa (eye worm)	fibroinase	0.0110966	0.0964258	0.0964258
Onchocerca volvulus	Bile acid receptor homolog	0.0413107	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0218238	0.41723	0.41723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0194869	0.347342	0.277693
Schistosoma mansoni	cathepsin F (C01 family)	0.0110966	0.0964258	0.0964258
Brugia malayi	Steroid receptor seven-up type 2	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0413107	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0165782	0.260356	0.311511
Loa Loa (eye worm)	hypothetical protein	0.0218238	0.41723	0.41723
Brugia malayi	Papain family cysteine protease containing protein	0.0110966	0.0964258	0.0964258
Giardia lamblia	Cathepsin B precursor	0.0165782	0.260356	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0110966	0.0964258	0.0964258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0413107	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0413107	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0218238	0.41723	0.41723
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0413107	1	1
Onchocerca volvulus		0.0194869	0.347342	0.347342
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0413107	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0413107	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0413107	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0110966	0.0964258	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0413107	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0110966	0.0964258	0.115372
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0194869	0.347342	0.347342
Echinococcus granulosus	thyroid hormone receptor alpha	0.0194869	0.347342	0.347342
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0413107	1	1
Loa Loa (eye worm)	hypothetical protein	0.0110966	0.0964258	0.0964258
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0194869	0.347342	0.277693
Brugia malayi	Cathepsin L-like precursor	0.0110966	0.0964258	0.0964258
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0110966	0.0964258	0.0964258
Schistosoma mansoni	retinoic acid receptor RXR	0.0413107	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0218238	0.41723	0.41723
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0110966	0.0964258	0.370361
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0358196	0.835786	1
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	nuclear hormone receptor family member odr-7	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0413107	1	1
Brugia malayi	nuclear receptor RXR	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	hypothetical protein	0.0413107	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0194869	0.347342	0.347342
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0413107	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0194869	0.347342	0.347342
Brugia malayi	Nuclear hormone receptor-like 1	0.0218238	0.41723	0.41723
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0413107	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0413107	1	1
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0194869	0.347342	0.347342
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0194869	0.347342	0.347342
Echinococcus granulosus	FTZ F1 alpha	0.0413107	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	ctsf protein	0.0110966	0.0964258	0.0964258
Loa Loa (eye worm)	hypothetical protein	0.0218238	0.41723	0.41723
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0413107	1	1
Onchocerca volvulus		0.0110966	0.0964258	0.0964258
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0413107	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0110966	0.0964258	0.115372
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0194869	0.347342	0.347342
Schistosoma mansoni	nuclear receptor	0.0194869	0.347342	0.347342
Schistosoma mansoni	nuclear hormone receptor	0.0194869	0.347342	0.347342
Brugia malayi	hypothetical protein	0.0218238	0.41723	0.41723
Loa Loa (eye worm)	cathepsin B	0.0165782	0.260356	0.260356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0110966	0.0964258	0.370361
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0413107	1	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0194869	0.347342	0.277693
Echinococcus granulosus	cathepsin b	0.0358196	0.835786	0.835786
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0413107	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0194869	0.347342	0.347342
Loa Loa (eye worm)	hypothetical protein	0.0218238	0.41723	0.41723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0413107	1	1
Giardia lamblia	Cathepsin B precursor	0.0165782	0.260356	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0110966	0.0964258	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0110966	0.0964258	0.370361
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0413107	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0165782	0.260356	1

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50	= 2.817 uM	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	ChEMBL.	18579783
EC50 (functional)	= 0.2257 uM	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783
EC50 (functional)	= 0.2641 uM	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	ChEMBL.	18579783

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2308884

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1736560