TDR Targets

Basic information

Technical information

TDR Targets ID: 173954
Name: (2S)-2-[[3-[[4-(4-fluorophenoxy)phenyl]methyl carbamoyl]-4-methoxyphenyl]methyl]butanoic ac id
MW: 451.487 | Formula: C26H26FNO5
H donors: 2 H acceptors: 3 LogP: 4.98 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@H](C(=O)O)Cc1ccc(c(c1)C(=O)NCc1ccc(cc1)Oc1ccc(cc1)F)OC
InChi: 1S/C26H26FNO5/c1-3-19(26(30)31)14-18-6-13-24(32-2)23(15-18)25(29)28-16-17-4-9-21(10-5-17)33-22-11-7-20(27)8-12-22/h4-13,15,19H,3,14,16H2,1-2H3,(H,28,29)(H,30,31)/t19-/m0/s1
InChiKey: VRHOBXXCNBZJRX-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2S)-2-[[3-[[4-(4-fluorophenoxy)phenyl]methylcarbamoyl]-4-methoxy-phenyl]methyl]butanoic acid
(2S)-2-[[3-[[[4-(4-fluorophenoxy)phenyl]methylamino]-oxomethyl]-4-methoxyphenyl]methyl]butanoic acid
(2S)-2-[3-[[4-(4-fluorophenoxy)benzyl]carbamoyl]-4-methoxy-benzyl]butyric acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor delta	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor alpha	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma japonicum	IPR008946,Nuclear receptor, ligand-binding,domain-containing	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	Get druggable targets OG5_137778	All targets in OG5_137778

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor delta	441 aa	369 aa	24.7 %
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor alpha	468 aa	397 aa	25.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Brugia malayi	hypothetical protein	0.1088	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	N chimaerin	0.0639	0.3156	0.2981
Echinococcus granulosus	signal transduction protein lnk realted	0.0639	0.3156	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	suppressor of cytokine signaling	0.0639	0.3156	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0449	0.0249	0.5
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1088	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0639	0.3156	0.2981
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0639	0.3156	0.2981
Onchocerca volvulus		0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Schistosoma mansoni	tensin	0.0639	0.3156	0.3156
Loa Loa (eye worm)	SH2 domain-containing protein	0.0639	0.3156	0.2981
Schistosoma mansoni	serine/threonine protein kinase	0.0449	0.0249	0.0249
Loa Loa (eye worm)	TK/ABL protein kinase	0.1088	1	1
Schistosoma mansoni	hypothetical protein	0.0449	0.0249	0.0249
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tensin	0.0639	0.3156	0.3156
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0639	0.3156	0.2981
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Brugia malayi	Protein kinase domain containing protein	0.1088	1	1
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0639	0.3156	0.2981
Echinococcus granulosus	SH2 motif	0.0639	0.3156	0.2981
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Toxoplasma gondii	STE kinase	0.0449	0.0249	0.5
Schistosoma mansoni	shc transforming protein	0.0639	0.3156	0.3156
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1088	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0639	0.3156	0.3156
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1088	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0639	0.3156	0.2981
Echinococcus granulosus	expressed conserved protein	0.0639	0.3156	0.2981
Onchocerca volvulus		0.1088	1	1
Giardia lamblia	Kinase, NEK	0.0449	0.0249	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tensin	0.0639	0.3156	0.3156
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1088	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	STAT protein	0.0639	0.3156	0.2981
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1088	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Brugia malayi	RhoGAP domain containing protein	0.0639	0.3156	0.2981
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0639	0.3156	0.3156
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0639	0.3156	0.2981
Giardia lamblia	Protein 21.1	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	adapter molecule crk	0.0639	0.3156	0.3156
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tensin-related	0.0639	0.3156	0.3156
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.1088	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0639	0.3156	0.2981
Onchocerca volvulus		0.0639	0.3156	0.2981
Brugia malayi	Protein kinase domain containing protein	0.1088	1	1
Schistosoma mansoni	hypothetical protein	0.0639	0.3156	0.3156
Plasmodium vivax	protein kinase, putative	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0639	0.3156	0.3156
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Schistosoma mansoni	suppressor of cytokine signaling	0.0639	0.3156	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Echinococcus multilocularis	SH2 motif	0.0639	0.3156	0.2981
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0639	0.3156	0.2981
Onchocerca volvulus		0.0639	0.3156	0.2981
Brugia malayi	Protein kinase domain containing protein	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0639	0.3156	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Loa Loa (eye worm)	SH2 domain-containing protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	SHC transforming protein 3	0.0639	0.3156	0.2981
Leishmania major	hypothetical protein, conserved	0.0449	0.0249	0.5
Onchocerca volvulus		0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0639	0.3156	0.3156
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1088	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0639	0.3156	0.3156
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0449	0.0249	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0639	0.3156	0.2981
Brugia malayi	SH2 domain containing protein	0.1088	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1088	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine kinase	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1088	1	1
Leishmania major	protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0639	0.3156	0.3156
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	SH2 domain containing protein 7	0.0639	0.3156	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Brugia malayi	Protein kinase domain containing protein	0.1088	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1088	1	1
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1088	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.1088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	tensin	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine kinase	0.1088	1	1
Schistosoma mansoni	GTPase activating protein	0.0639	0.3156	0.3156
Trypanosoma cruzi	protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0449	0.0249	0.0249
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Loa Loa (eye worm)	SRC-1	0.1088	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1088	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine protein kinase Srms	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Plasmodium falciparum	protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0639	0.3156	0.3156
Trichomonas vaginalis	STE family protein kinase	0.0449	0.0249	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1088	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0449	0.0249	0.0249
Brugia malayi	protein-tyrosine kinase	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0639	0.3156	0.2981
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0449	0.0249	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0639	0.3156	0.2981
Schistosoma mansoni	tensin-related	0.0639	0.3156	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.1088	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Echinococcus granulosus	tensin	0.0639	0.3156	0.2981
Schistosoma mansoni	nck2/grb4	0.0639	0.3156	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0639	0.3156	0.2981
Plasmodium falciparum	protein kinase, putative	0.0449	0.0249	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0639	0.3156	0.2981
Toxoplasma gondii	protein kinase	0.0449	0.0249	0.5
Brugia malayi	SRC-1	0.1088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1088	1	1
Echinococcus granulosus	N chimaerin	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Giardia lamblia	Kinase, NEK	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1088	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0449	0.0249	0.0249
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0639	0.3156	0.2981
Trichomonas vaginalis	TK family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Entamoeba histolytica	protein kinase, putative	0.0639	0.3156	0.2981
Brugia malayi	SH2 domain containing protein	0.1088	1	1
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Echinococcus multilocularis	tensin	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0639	0.3156	0.2981
Onchocerca volvulus		0.0639	0.3156	0.2981
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1088	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0639	0.3156	0.2981
Echinococcus multilocularis		0.0639	0.3156	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	vav2	0.0639	0.3156	0.3156
Onchocerca volvulus		0.0639	0.3156	0.2981
Plasmodium falciparum	protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	tyrosine protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0449	0.0249	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0449	0.0249	0.5
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Brugia malayi	Tyrosine-protein kinase abl-1	0.1088	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0449	0.0249	0.5
Onchocerca volvulus		0.1088	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1088	1	1
Schistosoma mansoni	hypothetical protein	0.0639	0.3156	0.3156
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	c src tyrosine kinase	0.1088	1	1
Echinococcus multilocularis	SH2 motif	0.0639	0.3156	0.2981
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0639	0.3156	0.2981
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Brugia malayi	Tensin	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine protein kinase Blk	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	SH2A	0.0639	0.3156	0.3156
Onchocerca volvulus		0.0639	0.3156	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	ephrin receptor	0.0449	0.0249	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Giardia lamblia	Kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1088	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	protein tyrosine kinase	0.0449	0.0249	0.0249
Echinococcus granulosus	SH2 motif	0.0639	0.3156	0.2981
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0639	0.3156	0.2981
Brugia malayi	Variant SH3 domain containing protein	0.0639	0.3156	0.2981
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1088	1	1
Schistosoma mansoni	ephrin receptor	0.0449	0.0249	0.0249
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	CAMK family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	NCK adaptor protein	0.0639	0.3156	0.2981
Loa Loa (eye worm)	TK protein kinase	0.1088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Brugia malayi	hypothetical protein	0.0639	0.3156	0.2981
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0639	0.3156	0.3156
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0639	0.3156	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	tyrosine kinase	0.1088	1	1
Echinococcus granulosus	hypothetical protein	0.0639	0.3156	0.2981
Plasmodium falciparum	tyrosine kinase-like protein	0.0449	0.0249	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1088	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1088	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Schistosoma mansoni	protein kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0449	0.0249	0.5
Onchocerca volvulus		0.1088	1	1
Leishmania major	protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	serine/threonine RGC	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1088	1	1
Brugia malayi	SH2 domain containing protein	0.0639	0.3156	0.2981
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0639	0.3156	0.2981
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1088	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3156	0.2981
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0449	0.0249	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0449	0.0249	0.5
Onchocerca volvulus		0.1088	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.1088	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1088	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1088	1	1
Trypanosoma brucei	protein kinase, putative	0.0449	0.0249	0.5
Onchocerca volvulus		0.1088	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1088	1	1
Trypanosoma cruzi	protein kinase, putative	0.0449	0.0249	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1088	1	1
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Schistosoma mansoni	tyrosine kinase	0.1088	1	1
Echinococcus multilocularis	SH2 motif	0.0639	0.3156	0.2981
Schistosoma mansoni	tyrosine kinase	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0449	0.0249	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0449	0.0249	0.0249
Trichomonas vaginalis	TKL family protein kinase	0.0449	0.0249	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0639	0.3156	0.2981

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.000615 uM	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 0.000615 uM	Transcriptional activation activity on human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 0.013 uM	Transactivation of human PPARalpha expressed in CHO-K1 cells	ChEMBL.	22133631
EC50 (binding)	= 0.014 uM	Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 0.014 uM	Transcriptional activation activity on human T279M-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 0.667 uM	Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 0.667 uM	Transcriptional activation activity on human I272F-mutant Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells	ChEMBL.	12951082
EC50 (binding)	= 1.92 uM	Transactivation of human PPARdelta expressed in CHO-K1 cells	ChEMBL.	22133631
EC50 (binding)	= 2.5 uM	Transactivation of human PPARgamma expressed in CHO-K1 cells	ChEMBL.	22133631
Ratio (binding)	= 2.28	Ratio of transcriptional activation of T279M mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells	ChEMBL.	12951082
Ratio (binding)	= 108	Ratio of transcriptional activation of I272F mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells	ChEMBL.	12951082
Ratio (binding)	= 2.28	Ratio of transcriptional activation of T279M mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells	ChEMBL.	12951082
Ratio (binding)	= 108	Ratio of transcriptional activation of I272F mutant compared to wild type PPAR-GAL4 chimeric receptors in CHO-K1 cells	ChEMBL.	12951082

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL318351
PubChem: 9825046

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 173954