TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.531 | Formula: C25H31N3O4
H donors: 1 H acceptors: 2 LogP: 2.83 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)CN1CCC2(Oc3c1cccc3)CCN(CC2)C(=O)CNC(=O)C
InChi: 1S/C25H31N3O4/c1-19(29)26-17-24(30)27-13-10-25(11-14-27)12-15-28(22-8-3-4-9-23(22)32-25)18-20-6-5-7-21(16-20)31-2/h3-9,16H,10-15,17-18H2,1-2H3,(H,26,29)
InChiKey: CCUHMZFDDXPVDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0082	0.3455	0.9376
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0082	0.3455	0.9376
Echinococcus granulosus	neuropeptide Y receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	amine GPCR	0.0082	0.3455	1
Brugia malayi	Melatonin receptor type 1A	0.0082	0.3455	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0082	0.3455	0.3455
Echinococcus granulosus	g-protein coupled receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	g protein coupled receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Brugia malayi	sulfakinin receptor protein	0.0082	0.3455	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0082	0.3455	0.9376
Brugia malayi	Dopamine receptor protein 2	0.0082	0.3455	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0082	0.3455	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Plasmodium falciparum	stearoyl-CoA desaturase	0.0068	0.2711	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0082	0.3455	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	neuropeptides capa receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	serotonin receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	fmrfamide receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	amine GPCR	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0082	0.3455	0.3455
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0082	0.3455	1
Brugia malayi	putative neuropeptide receptor	0.0082	0.3455	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	dro:myosuppressin receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Onchocerca volvulus		0.0082	0.3455	0.9376
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	opsin-like receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0082	0.3455	1
Echinococcus multilocularis	somatostatin receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	biogenic amine receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	fmrfamide receptor	0.0082	0.3455	0.3455
Brugia malayi	G-protein coupled receptor	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Brugia malayi	follicle stimulating hormone receptor	0.0082	0.3455	1
Echinococcus multilocularis	fmrfamide receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0082	0.3455	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	acyl-CoA desaturase	0.0068	0.2711	0.7847
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	hypothetical protein	0.0082	0.3455	1
Brugia malayi	Serotonin receptor	0.0082	0.3455	1
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0018	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.3455	0.3455
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0082	0.3455	1
Brugia malayi	Dopamine receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0082	0.3455	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0082	0.3455	0.3455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Schistosoma mansoni	myosin xvIII	0.0082	0.3455	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0082	0.3455	1
Toxoplasma gondii	sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein	0.0018	0	0.5
Onchocerca volvulus		0.0082	0.3455	0.9376
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0082	0.3455	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0082	0.3455	0.3455
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Mycobacterium ulcerans	electron transfer protein FdxB	0.0018	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0082	0.3455	1
Echinococcus granulosus	G protein coupled receptor 139	0.0082	0.3455	0.3455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	GnHR receptor homolog	0.0082	0.3455	1
Brugia malayi	RE15519p	0.0082	0.3455	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Brugia malayi	AKH receptor	0.0082	0.3455	1
Echinococcus granulosus	neuropeptide receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0082	0.3455	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.3455	0.3455
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0018	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0082	0.3455	0.3455
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0018	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Schistosoma mansoni	neuropeptide F-like receptor	0.0082	0.3455	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.3455	0.3455
Echinococcus multilocularis	neuropeptide receptor A26	0.0082	0.3455	0.3455
Loa Loa (eye worm)	melatonin receptor type 1A	0.0082	0.3455	1
Schistosoma mansoni	neuropeptide receptor	0.0082	0.3455	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	allatostatin A receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	serotonin receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0082	0.3455	0.3455
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	expressed protein	0.0203	1	1
Schistosoma mansoni	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.3455	0.3455
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0018	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0082	0.3455	0.3455
Brugia malayi	ORL1-like opioid receptor	0.0082	0.3455	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	neuropeptide s receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	7TM GPCR rhodopsin	0.0082	0.3455	0.3455
Onchocerca volvulus		0.0086	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.3455	0.3455
Echinococcus granulosus	neuropeptide Y receptor	0.0082	0.3455	0.3455
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0082	0.3455	1
Echinococcus granulosus	neuropeptides capa receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	somatostatin receptor	0.0082	0.3455	0.3455
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2711	0.7358
Schistosoma mansoni	neuropeptide receptor	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	opsin-like receptor	0.0082	0.3455	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	hypothetical protein	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0068	0.2711	0.5
Onchocerca volvulus		0.0082	0.3455	0.9376
Brugia malayi	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0082	0.3455	0.3455
Onchocerca volvulus		0.0082	0.3455	0.9376
Loa Loa (eye worm)	TYRA-2 protein	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide s receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0082	0.3455	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0082	0.3455	1
Schistosoma mansoni	adenoreceptor	0.0082	0.3455	1
Brugia malayi	Serotonin receptor	0.0082	0.3455	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0082	0.3455	0.3455
Loa Loa (eye worm)	neuropeptide F receptor	0.0082	0.3455	1
Brugia malayi	neuropeptide F receptor	0.0082	0.3455	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0082	0.3455	0.3455
Onchocerca volvulus		0.0082	0.3455	0.9376
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Echinococcus multilocularis	orexin receptor type 2	0.0082	0.3455	0.3455
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0082	0.3455	1
Schistosoma mansoni	neuropeptide receptor	0.0082	0.3455	1
Brugia malayi	G-protein coupled receptor	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Brugia malayi	putative neuropeptide receptor NPR1	0.0082	0.3455	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0082	0.3455	1
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	neuropeptides capa receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0082	0.3455	0.3455
Echinococcus granulosus	neuropeptide receptor A26	0.0082	0.3455	0.3455
Echinococcus granulosus	g protein coupled receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Echinococcus multilocularis	sex peptide receptor	0.0082	0.3455	0.3455
Echinococcus granulosus	biogenic amine 5HT receptor	0.0082	0.3455	0.3455
Onchocerca volvulus		0.0082	0.3455	0.9376
Schistosoma mansoni	histamine h1 receptor	0.0082	0.3455	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0082	0.3455	1
Brugia malayi	larval opioid receptor	0.0082	0.3455	1
Echinococcus granulosus	orexin receptor type 2	0.0082	0.3455	0.3455
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0082	0.3455	1
Mycobacterium ulcerans	hypothetical protein	0.0018	0	0.5
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2711	0.7358
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Brugia malayi	neuropeptide F receptor	0.0082	0.3455	1
Echinococcus multilocularis	allatostatin A receptor	0.0082	0.3455	0.3455
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.3455	0.3455
Onchocerca volvulus		0.0082	0.3455	0.9376
Schistosoma mansoni	biogenic amine receptor	0.0082	0.3455	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.3455	0.3455
Schistosoma mansoni	amine GPCR	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0082	0.3455	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0082	0.3455	1
Schistosoma mansoni	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	g-protein coupled receptor	0.0082	0.3455	0.3455
Leishmania major	stearic acid desaturase, putative	0.0086	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	G-protein coupled receptor	0.0082	0.3455	1
Schistosoma mansoni	biogenic amine receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Onchocerca volvulus		0.0086	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Leishmania major	fatty-acid desaturase, putative	0.0086	0.3684	1
Brugia malayi	acyl-CoA desaturase	0.0068	0.2711	0.7847
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.3455	1
Trypanosoma cruzi	fatty acid desaturase, putative	0.0086	0.3684	1
Mycobacterium ulcerans	hypothetical protein	0.0018	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0082	0.3455	0.3455
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	amine GPCR	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	neuropeptide receptor	0.0082	0.3455	0.3455
Schistosoma mansoni	neuropeptide receptor	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0082	0.3455	0.3455
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	Dopamine receptor protein 1	0.0082	0.3455	1
Onchocerca volvulus		0.0082	0.3455	0.9376
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Brugia malayi	G protein-coupled receptor	0.0082	0.3455	1
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0018	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0082	0.3455	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0082	0.3455	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	G-protein coupled receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	sex peptide receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Echinococcus granulosus	neuropeptides capa receptor	0.0082	0.3455	0.3455
Trypanosoma brucei	fatty acid desaturase, putative	0.0086	0.3684	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.3455	1
Schistosoma mansoni	amine GPCR	0.0082	0.3455	1
Echinococcus multilocularis	serotonin receptor	0.0082	0.3455	0.3455
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3455	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.8 uM	Inhibition of rat SCD1 by rat microsomal assay	ChEMBL.	23265904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2315501

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1740178