Detailed information for compound 1740350

Basic information

Technical information
  • TDR Targets ID: 1740350
  • Name: [1-[(5S,7S)-2,2,7-trimethyl-4,9-dioxo-3,8-dio xaspiro[4.4]nonan-7-yl]ethylideneamino]thiour ea
  • MW: 313.373 | Formula: C13H19N3O4S
  • H donors: 2 H acceptors: 2 LogP: 0.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=N\NC(=S)N)/[C@@]1(C)OC(=O)[C@]2(C1)CC(OC2=O)(C)C
  • InChi: 1S/C13H19N3O4S/c1-7(15-16-10(14)21)12(4)6-13(9(18)20-12)5-11(2,3)19-8(13)17/h5-6H2,1-4H3,(H3,14,16,21)/b15-7+/t12-,13-/m0/s1
  • InChiKey: YQINBAFGCQXUBM-GTDURTQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [1-[(5S,7S)-4,9-diketo-2,2,7-trimethyl-3,8-dioxaspiro[4.4]nonan-7-yl]ethylideneamino]thiourea
  • ZINC01301035

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0027 0.1033 0.1033
Loa Loa (eye worm) fibroinase 0.0027 0.1033 0.1168
Brugia malayi cathepsin L-like precursor 0.0018 0.031 0.031
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1033 0.4245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1033 0.4852
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.1033 0.1168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0975 0.1102
Onchocerca volvulus 0.0018 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0018 0.031 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Onchocerca volvulus 0.0027 0.1033 0.1033
Loa Loa (eye worm) ctsf protein 0.0027 0.1033 0.1168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.031 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Leishmania major cysteine peptidase A (CPA) 0.0027 0.1033 0.4852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Mycobacterium ulcerans aminopeptidase N PepN 0.004 0.2129 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.2434 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Brugia malayi Cathepsin L-like precursor 0.0018 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.004 0.2129 1
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Loa Loa (eye worm) hypothetical protein 0.0018 0.031 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Loa Loa (eye worm) hypothetical protein 0.0027 0.1033 0.1168
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1033 0.4852
Loa Loa (eye worm) hypothetical protein 0.0026 0.0975 0.1102
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.1033 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1033 0.4245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.004 0.2129 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0975 0.4578
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1033 0.3975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.031 0.1455
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1033 0.4852
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1033 0.1033
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.1033 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.004 0.2129 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.031 0.1455
Plasmodium vivax vivapain-2 0.0027 0.1033 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1033 0.1033
Onchocerca volvulus 0.0027 0.1033 0.1033
Plasmodium vivax vivapain-2 0.0027 0.1033 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Onchocerca volvulus 0.004 0.2129 0.2129
Trypanosoma cruzi Aminopeptidase M1, putative 0.004 0.2129 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.004 0.2129 0.2129
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.1033 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1033 0.1033
Onchocerca volvulus 0.0137 1 1
Trypanosoma cruzi aminopeptidase, putative 0.004 0.2129 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.8846 1
Onchocerca volvulus Cathepsin F homolog 0.0027 0.1033 0.1033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.1033 0.1033
Entamoeba histolytica cysteine protease, putative 0.0027 0.1033 0.3975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.031 0.1455
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Loa Loa (eye worm) peptidase family M1 containing protein 0.0111 0.7871 0.8898
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1033 0.4852
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1033 0.1033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Onchocerca volvulus 0.0027 0.1033 0.1033
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1033 0.4852
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Trypanosoma brucei Aminopeptidase M1, putative 0.004 0.2129 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1033 0.4852
Echinococcus granulosus aminopeptidase N 0.0137 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Brugia malayi hypothetical protein 0.004 0.2129 0.2129
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0975 0.0975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Loa Loa (eye worm) hypothetical protein 0.0018 0.031 0.035
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.004 0.2129 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.004 0.2129 0.8749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Entamoeba histolytica aminopeptidase, putative 0.004 0.2129 1
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Brugia malayi Cathepsin L-like precursor 0.0027 0.1033 0.1033
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1033 0.3975
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.1033 0.1033
Brugia malayi Cathepsin L-like precursor 0.0018 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0097 0.6717 0.7593
Echinococcus granulosus cathepsin l1 0.0018 0.031 0.031
Toxoplasma gondii cathepsin CPL 0.0027 0.1033 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Echinococcus multilocularis cysteine protease 0.0027 0.1033 0.1033
Onchocerca volvulus 0.0027 0.1033 0.1033
Onchocerca volvulus 0.0027 0.1033 0.1033
Echinococcus multilocularis cysteine protease 0.0027 0.1033 0.1033
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.1033 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.004 0.2129 1
Loa Loa (eye worm) aminopeptidase N 0.004 0.2129 0.2407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Onchocerca volvulus 0.0027 0.1033 0.1033
Echinococcus multilocularis aminopeptidase N 0.0137 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Echinococcus granulosus puromycin sensitive aminopeptidase 0.004 0.2129 0.2129
Brugia malayi Peptidase family M1 containing protein 0.004 0.2129 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.031 0.1273
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.1033 0.1033
Echinococcus granulosus cathepsin l1 0.0027 0.1033 0.1033
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.004 0.2129 1
Leishmania major cathepsin L-like protease 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1033 0.4852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1033 0.4852
Loa Loa (eye worm) cysteine protease 0.0027 0.1033 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0026 0.0975 0.4005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1033 0.4852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1033 0.4852
Trypanosoma brucei Aminopeptidase M1, putative 0.004 0.2129 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.8 uM Inhibition of human recombinant His-tagged cathepsin K using Cbz-Phe-Arg-AMC as substrate incubated for 30 mins prior to substrate addition by FRET assay ChEMBL. 23350811
Inhibition (binding) Covalent reversible inhibition of human recombinant His-tagged cathepsin K using Cbz-Phe-Arg-AMC as substrate at 333-fold IC50 incubated for 30 mins prior to substrate addition followed by 333-fold dilution measured up to 60 mins by rapid dilution assay ChEMBL. 23350811

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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