Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0898 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.0244 | 0.0244 |
Brugia malayi | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Onchocerca volvulus | 0.0096 | 0.0661 | 0.0428 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.004 | 0.004 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.0244 | 0.0205 |
Echinococcus granulosus | wd40 repeat | 0.0074 | 0.0402 | 0.0364 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.0661 | 0.0624 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0661 | 0.5 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0074 | 0.0402 | 0.0364 |
Onchocerca volvulus | 0.0898 | 1 | 1 | |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0074 | 0.0402 | 0.0364 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0898 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0661 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.0661 | 0.0624 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0661 | 1 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0661 | 0.0624 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0074 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0305 | 0.0305 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0661 | 0.5 |
Echinococcus granulosus | protein will die slowly | 0.0898 | 1 | 1 |
Echinococcus multilocularis | protein will die slowly | 0.0898 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0898 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.0661 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0661 | 0.0661 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0661 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0402 | 0.0402 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0661 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0661 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0661 | 0.0661 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0661 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0661 | 0.0661 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.0661 | 1 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0661 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.004 | 0.004 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0661 | 0.5 |
Echinococcus multilocularis | wd40 repeat | 0.0074 | 0.0402 | 0.0364 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0661 | 0.5 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0043 | 0.004 | 0.004 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0661 | 0.0624 |
Onchocerca volvulus | 0.0096 | 0.0661 | 0.0428 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0402 | 0.0402 |
Onchocerca volvulus | 0.0096 | 0.0661 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 135 nM | Induction of human pancreatic glucokinase activity at 5 mM glucose concentration | ChEMBL. | 23218712 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.