Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.1178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0384 | 1 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.1346 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0384 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0181 | 0.3931 | 0.2987 |
Onchocerca volvulus | 0.0384 | 1 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0384 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0384 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0258 | 0.6243 | 0.5658 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0384 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0384 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0384 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1346 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | conserved hypotetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0203 | 0.4581 | 0.3738 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | nuclear receptor RXR | 0.0203 | 0.4581 | 0.3738 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.1346 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | nuclear receptor | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0384 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0384 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.6243 | 0.5658 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | FTZ F1 alpha | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0384 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | nuclear receptor NHR-88 | 0.0181 | 0.3931 | 0.2987 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.1346 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0384 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0384 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0203 | 0.4581 | 0.3738 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0384 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0181 | 0.3931 | 0.2987 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.1346 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0384 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0384 | 1 | 1 |
Brugia malayi | tailless protein | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0384 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0203 | 0.4581 | 0.3738 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | zinc finger protein | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0258 | 0.6243 | 0.5658 |
Brugia malayi | Carboxylesterase family protein | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0181 | 0.3931 | 0.2987 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0384 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0203 | 0.4581 | 0.3738 |
Brugia malayi | Carboxylesterase family protein | 0.0258 | 0.6243 | 0.5658 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.1346 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | thyroid hormone receptor | 0.0384 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | coup transcription factor | 0.0384 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0384 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.1346 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | acetylcholinesterase | 0.0258 | 0.6243 | 0.5658 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.1346 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.1178 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0384 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0181 | 0.3931 | 0.2987 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1346 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0384 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0384 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0384 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0384 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.1346 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0384 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0384 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0384 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0203 | 0.4581 | 0.3738 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Schistosoma mansoni | nuclear hormone receptor | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0384 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3931 | 0.2987 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0181 | 0.3931 | 0.2987 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0384 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0384 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1346 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0384 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0384 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0384 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0384 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.4581 | 0.3738 |
Brugia malayi | nuclear receptor NHR-88 | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.6243 | 0.5658 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0384 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0203 | 0.4581 | 0.3738 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1346 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0181 | 0.3931 | 0.2987 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0384 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.1346 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0181 | 0.3931 | 0.2987 |
Echinococcus granulosus | carboxylesterase 5A | 0.0258 | 0.6243 | 0.5658 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0384 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1346 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.