Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0175 | 0.1763 | 0.1763 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.033 | 0.3735 | 0.3437 |
Echinococcus granulosus | thymidylate synthase | 0.0821 | 1 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0073 | 0.0453 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0073 | 0.0453 | 0.0453 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.033 | 0.3735 | 0.3437 |
Trypanosoma brucei | RNA helicase, putative | 0.0135 | 0.1242 | 0.0827 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.033 | 0.3735 | 0.3734 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0391 | 0.4508 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0391 | 0.4508 | 0.4248 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0043 | 0.0072 | 0.1581 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0073 | 0.0453 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0043 | 0.0072 | 0.1581 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0129 | 0.0129 |
Brugia malayi | hypothetical protein | 0.0169 | 0.168 | 0.168 |
Mycobacterium ulcerans | thymidylate synthase | 0.0821 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Onchocerca volvulus | 0.0821 | 1 | 1 | |
Echinococcus multilocularis | thymidylate synthase | 0.0821 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0821 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0129 | 0.0129 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.033 | 0.3735 | 0.3734 |
Echinococcus granulosus | thymidylate kinase | 0.0073 | 0.0453 | 0.0453 |
Schistosoma mansoni | single-minded | 0.005 | 0.0167 | 0.0167 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.033 | 0.3735 | 0.3734 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.005 | 0.0167 | 0.0167 |
Echinococcus multilocularis | thymidylate kinase | 0.0073 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.168 | 0.1571 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0156 | 0.1513 | 0.1513 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0391 | 0.4508 | 0.4248 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0043 | 0.0072 | 0.1581 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | thymidylate kinase | 0.0073 | 0.0453 | 0.0328 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1763 | 0.1763 |
Echinococcus multilocularis | geminin | 0.0175 | 0.1763 | 0.1763 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0129 | 0.0129 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.033 | 0.3735 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.1242 | 0.1242 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0129 | 0.0129 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.0167 | 0.0167 |
Brugia malayi | thymidylate kinase | 0.0073 | 0.0453 | 0.0453 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.033 | 0.3735 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0821 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1763 | 0.1763 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Giardia lamblia | CDC8 | 0.0073 | 0.0453 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0043 | 0.0072 | 0.1581 |
Schistosoma mansoni | thymidylate kinase | 0.0073 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0156 | 0.1513 | 0.1402 |
Brugia malayi | hypothetical protein | 0.0391 | 0.4508 | 0.4508 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.033 | 0.3735 | 0.3437 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0821 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0073 | 0.0453 | 0.0452 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0129 | 0.0129 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0821 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0129 | 0.0129 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0043 | 0.0072 | 0.1581 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0073 | 0.0453 | 0.0452 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0821 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0129 | 0.0129 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0453 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 4 ug ml-1 | Inhibition of radiolabeled C5a binding to its membrane bound C5a anaphylatoxin chemotactic receptor | ChEMBL. | No reference |
MPO release (functional) | = 0.3 ug ml-1 | Nonspecific degranulation of polymorho neutrophils as measured by myeloperoxidase (MPO) release in a whole functional cell assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.