TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 709.837 | Formula: C29H43N9O8S2
H donors: 8 H acceptors: 8 LogP: -4.68 Rotable bonds: 11
Rule of 5 violations (Lipinski): 3
SMILES: NC(=NCCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(SSC[C@@H](C(=O)N1C)NCC(=O)c1ccccc1)(C)C)C(=O)N)N
InChi: 1S/C29H43N9O8S2/c1-29(2)23(24(30)43)37-25(44)17(12-22(41)42)36-21(40)14-35-26(45)19(10-7-11-33-28(31)32)38(3)27(46)18(15-47-48-29)34-13-20(39)16-8-5-4-6-9-16/h4-6,8-9,17-19,23,34H,7,10-15H2,1-3H3,(H2,30,43)(H,35,45)(H,36,40)(H,37,44)(H,41,42)(H4,31,32,33)/t17-,18-,19-,23-/m0/s1
InChiKey: GQTKXTJVRLZDDD-KGYLXKDPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	Starlite/ChEMBL	References
Homo sapiens	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Integrin beta-PS precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	ko:K06464 integrin beta 2, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin alpha	Get druggable targets OG5_129341	All targets in OG5_129341
Echinococcus multilocularis	integrin alpha 3	Get druggable targets OG5_129341	All targets in OG5_129341
Loa Loa (eye worm)	integrin beta-2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus granulosus	integrin alpha 3	Get druggable targets OG5_129341	All targets in OG5_129341
Brugia malayi	Integrin beta pat-3 precursor	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	Integrin beta-3 precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Loa Loa (eye worm)	integrin alpha pat-2	Get druggable targets OG5_129341	All targets in OG5_129341
Brugia malayi	Integrin alpha pat-2 precursor	Get druggable targets OG5_129341	All targets in OG5_129341
Echinococcus multilocularis	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus granulosus	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin beta subunit	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing	Get druggable targets OG5_129341	All targets in OG5_129341
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129341	All targets in OG5_129341
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129341	All targets in OG5_129341
Schistosoma japonicum	ko:K06476 integrin alpha 2B, putative	Get druggable targets OG5_129341	All targets in OG5_129341

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	CDC72	0.1505	0.4139	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0846	0.1173
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0265	0.0379	0.042
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0657	0.1568	0.2339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2223	0.6316	1
Trypanosoma brucei	N-myristoyltransferase	0.1505	0.4139	1
Echinococcus multilocularis	integrin beta 2	0.028	0.0426	0.0421
Schistosoma mansoni	N-myristoyltransferase	0.1505	0.4139	0.4068
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0192	0.0157	0.039
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.1505	0.4139	0.4135
Schistosoma mansoni	integrin beta subunit	0.0223	0.0252	0.0135
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.0197	0.0227
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0655	0.1562	0.233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0743	0.1008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Echinococcus multilocularis	serine protein kinase ATM	0.0179	0.0119	0.0113
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0336	0.0595	0.0769
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0655	0.1562	0.3591
Schistosoma mansoni	integrin alpha	0.0185	0.0136	0.0018
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.2223	0.6316	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.3439	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.2223	0.6316	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0265	0.0379	0.0374
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0336	0.0595	0.4825
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.2223	0.6316	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0346	0.0624	0.1257
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0336	0.0595	0.0942
Brugia malayi	N-myristoyltransferase 2	0.1505	0.4139	0.6552
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0157	0.0181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.0938	0.1322
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.2223	0.6316	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0763	0.1889	0.1791
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.1142	0.3039	0.7021
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0655	0.1562	0.233
Brugia malayi	Integrin beta pat-3 precursor	0.0378	0.0723	0.1145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0462	0.0976	0.1384
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0179	0.0119	0.0113
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1417	0.3872	0.613
Onchocerca volvulus		0.0233	0.0283	0.5
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0655	0.1562	0.3148
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0763	0.1889	0.2856
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1215	0.326	0.5161
Loa Loa (eye worm)	N-myristoyltransferase 2	0.1505	0.4139	0.4754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0846	0.1173
Loa Loa (eye worm)	phosphatidylinositol 3	0.3012	0.8706	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0336	0.0595	0.059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.1505	0.4139	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0336	0.0595	0.059
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0179	0.0119	0.0188
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0763	0.1889	0.2856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0535	0.1198	0.1742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0384	0.0742	0.1006
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.0283	0.0266
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0336	0.0595	0.0482
Trypanosoma cruzi	target of rapamycin kinase 3	0.0535	0.12	0.1744
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0532	0.119	0.201
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0336	0.0595	0.4825
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0336	0.0595	0.0769
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.1417	0.3872	0.3869
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.2223	0.6316	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0288	0.0449	0.5
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0141	0.0003	0.5
Brugia malayi	glutaminase DH11.1	0.0269	0.0392	0.0621
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0265	0.0379	0.0648
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0655	0.1562	0.1558
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0312	0.0522	0.1002
Giardia lamblia	GTOR	0.0655	0.1562	0.3019
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0655	0.1562	0.1461
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0655	0.1562	0.3591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.1562	0.233
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0265	0.0379	0.0374
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.1505	0.4139	0.6486
Echinococcus granulosus	serine protein kinase ATM	0.0179	0.0119	0.0113
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0763	0.1889	0.2856
Trypanosoma brucei	N-myristoyl transferase, putative	0.1505	0.4139	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0763	0.1889	0.299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0569	0.1302	0.1909
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.3439	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0265	0.0379	0.042
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0655	0.1562	0.233
Trichomonas vaginalis	N-myristoyl transferase, putative	0.1505	0.4139	0.6486
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.1505	0.4139	0.4135
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0763	0.1889	0.2856
Loa Loa (eye worm)	glutaminase	0.0269	0.0392	0.045
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0655	0.1562	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0806	0.2021	0.2321
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0763	0.1889	0.4403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0535	0.1198	0.1742
Trichomonas vaginalis	glutaminase, putative	0.0269	0.0392	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0265	0.0379	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0415	0.0835	0.1156
Brugia malayi	Pre-SET motif family protein	0.0205	0.0197	0.0313
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0336	0.0595	0.1185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.2223	0.6316	1
Loa Loa (eye worm)	integrin beta-2	0.0378	0.0723	0.0831
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0384	0.0742	0.1006
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.1505	0.4139	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0265	0.0379	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.1562	0.233
Echinococcus multilocularis	Zinc finger, PHD finger	0.0336	0.0595	0.059
Loa Loa (eye worm)	glutaminase 2	0.0269	0.0392	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.1417	0.3872	0.3869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0265	0.0379	0.042
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0763	0.1889	0.2856
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0655	0.1562	0.1558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0535	0.1198	0.1742
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0265	0.0379	0.042
Loa Loa (eye worm)	phosphatidylinositol 3	0.0655	0.1562	0.1795
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0535	0.12	0.2183
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0179	0.0119	0.0000000037752
Loa Loa (eye worm)	integrin alpha pat-2	0.0285	0.0439	0.0505
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1569	0.4333	0.68
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0336	0.0595	0.0575
Loa Loa (eye worm)	phosphatidylinositol 3	0.0657	0.1568	0.1802
Trypanosoma cruzi	N-myristoyl transferase, putative	0.1505	0.4139	0.6486
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0179	0.0119	0.0113
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0336	0.0595	0.059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0415	0.0835	0.1156
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.099	0.2579	0.3969
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0225	0.026	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0119	0.0136
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Echinococcus granulosus	integrin beta 2	0.028	0.0426	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0535	0.1198	0.1742
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0336	0.0595	0.0769
Mycobacterium ulcerans	glutaminase	0.0269	0.0392	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0535	0.12	0.2689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0265	0.0379	0.042
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0336	0.0595	0.0769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0535	0.1198	0.1742
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0655	0.1562	0.3148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0265	0.0379	0.042
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0141	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.1417	0.3872	0.4448
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0336	0.0595	0.0769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0384	0.0742	0.1006
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Trypanosoma cruzi	N-myristoyl transferase, putative	0.1505	0.4139	0.6486
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1569	0.4333	0.68
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0743	0.1008
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1797	0.5023	0.7913
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0743	0.1008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0846	0.1173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0179	0.0119	0.0188
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0655	0.1562	0.233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0336	0.0595	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0016	0.0018
Entamoeba histolytica	hypothetical protein	0.1797	0.5023	0.7913
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0385	0.0743	0.1008
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0763	0.1889	0.2856
Brugia malayi	Integrin alpha pat-2 precursor	0.0185	0.0136	0.0216
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0336	0.0595	0.0769
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0265	0.0379	0.0263
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0336	0.0595	0.0482
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0336	0.0595	0.0684
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.2118	0.5996	0.9483
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0989	0.2574	0.3962
Schistosoma mansoni	glutaminase	0.0269	0.0392	0.0277
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0336	0.0595	0.0769
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.0449	0.0532
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0265	0.0379	0.06
Loa Loa (eye worm)	phosphatidylinositol 3	0.0265	0.0379	0.0435
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0505	0.1106	1
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0157	0.0062
Leishmania major	N-myristoyl transferase, putative	0.1505	0.4139	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.1562	0.233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.1106	0.1593

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.035 uM	Tested for inhibition of fibrinogen binding to purified GPIIb/IIIa isolated from human platelets and reconstituted in liposomes	ChEMBL.	8145226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2371468

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1744003