TDR Targets

Basic information

Technical information

TDR Targets ID: 174408
Name: [6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyr idin-3-yl]-pyrrolidin-1-ylmethanone
MW: 360.237 | Formula: C18H15Cl2N3O
H donors: 0 H acceptors: 2 LogP: 4.96 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1nc2n(c1C(=O)N1CCCC1)cc(cc2)Cl
InChi: 1S/C18H15Cl2N3O/c19-13-5-3-12(4-6-13)16-17(18(24)22-9-1-2-10-22)23-11-14(20)7-8-15(23)21-16/h3-8,11H,1-2,9-10H2
InChiKey: JXGWOCDIVNXAMU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-pyrrolidin-1-yl-methanone
[6-chloro-2-(4-chlorophenyl)-3-imidazo[1,2-a]pyridinyl]-(1-pyrrolidinyl)methanone
[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-pyrrolidino-methanone
[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-pyrrolidin-1-ylmethanone
[6-chloro-2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-pyrrolidin-1-yl-methanone
[6-chloro-2-(4-chlorophenyl)-3-imidazo[3,2-a]pyridinyl]-1-pyrrolidinylmethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0457	0.4149	0.4149
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0725	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0457	0.4149	0.4149
Plasmodium falciparum	tyrosine kinase-like protein	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0457	0.4149	0.4149
Schistosoma mansoni	tensin	0.0457	0.4149	0.4149
Schistosoma mansoni	vav2	0.0457	0.4149	0.4149
Echinococcus granulosus	signal transduction protein lnk realted	0.0457	0.4149	0.4149
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0457	0.4149	0.4149
Plasmodium falciparum	protein kinase, putative	0.0268	0	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0725	1	1
Trypanosoma cruzi	protein kinase, putative	0.0268	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0457	0.4149	0.4149
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0457	0.4149	0.4149
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Entamoeba histolytica	hypothetical protein	0.0279	0.024	0.024
Leishmania major	protein kinase, putative	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0268	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0457	0.4149	0.4149
Schistosoma mansoni	GTPase activating protein	0.0457	0.4149	0.4149
Brugia malayi	hypothetical protein	0.0457	0.4149	0.4149
Trypanosoma brucei	protein kinase, putative	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0725	1	1
Schistosoma mansoni	tensin-related	0.0457	0.4149	0.4149
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0268	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0457	0.4149	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	SH2 motif	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0457	0.4149	0.4149
Echinococcus granulosus	c src tyrosine kinase	0.0725	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0279	0.024	0.024
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0725	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0725	1	1
Onchocerca volvulus		0.0725	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Leishmania major	protein kinase, putative	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Schistosoma mansoni	tensin	0.0457	0.4149	0.4149
Echinococcus multilocularis	NCK adaptor protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0725	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Toxoplasma gondii	protein kinase	0.0268	0	0.5
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Onchocerca volvulus		0.0725	1	1
Trypanosoma cruzi	protein kinase, putative	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0725	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0725	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0457	0.4149	0.4149
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0725	1	1
Schistosoma mansoni	hypothetical protein	0.0457	0.4149	0.4149
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0725	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0725	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0457	0.4149	0.4149
Echinococcus multilocularis		0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0725	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0725	1	1
Loa Loa (eye worm)	SRC-1	0.0725	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0457	0.4149	0.4149
Echinococcus multilocularis	SHC transforming protein 3	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0725	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0725	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0268	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0457	0.4149	0.4149
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Schistosoma mansoni	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	c src tyrosine kinase	0.0725	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0457	0.4149	0.4149
Schistosoma mansoni	tensin-related	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	SH2 domain containing protein	0.0725	1	1
Echinococcus granulosus	tyrosine kinase	0.0725	1	1
Echinococcus granulosus	tensin	0.0457	0.4149	0.4149
Entamoeba histolytica	SH2 domain containing protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus multilocularis	SH2 motif	0.0457	0.4149	0.4149
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0457	0.4149	0.4149
Trypanosoma brucei	Pseudokinase, putative	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus granulosus	tyrosine protein kinase Srms	0.0725	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0268	0	0.5
Schistosoma mansoni	nck2/grb4	0.0457	0.4149	0.4149
Entamoeba histolytica	hypothetical protein	0.0279	0.024	0.024
Brugia malayi	Variant SH3 domain containing protein	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0457	0.4149	0.4149
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0268	0	0.5
Brugia malayi	hypothetical protein	0.0725	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0268	0	0.5
Brugia malayi	SRC-1	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Onchocerca volvulus		0.0457	0.4149	0.4149
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0457	0.4149	0.4149
Schistosoma mansoni	growth factor receptor-bound protein	0.0457	0.4149	0.4149
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0725	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0725	1	1
Plasmodium vivax	protein kinase, putative	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0725	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0457	0.4149	0.4149
Brugia malayi	protein-tyrosine kinase	0.0725	1	1
Loa Loa (eye worm)	TK protein kinase	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0725	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0457	0.4149	0.4149
Brugia malayi	Variant SH3 domain containing protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0725	1	1
Echinococcus multilocularis	tensin	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Schistosoma mansoni	SH2A	0.0457	0.4149	0.4149
Schistosoma mansoni	suppressor of cytokine signaling	0.0457	0.4149	0.4149
Echinococcus multilocularis	signal transduction protein lnk realted	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	SH2 domain containing protein	0.0725	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0457	0.4149	0.4149
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0457	0.4149	0.4149
Brugia malayi	Tensin	0.0457	0.4149	0.4149
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0268	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0725	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0725	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0457	0.4149	0.4149
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0457	0.4149	0.4149
Giardia lamblia	Kinase, NEK	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0725	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0457	0.4149	0.4149
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0268	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0268	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0457	0.4149	0.4149
Loa Loa (eye worm)	TK/ABL protein kinase	0.0725	1	1
Echinococcus granulosus	expressed conserved protein	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0725	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0457	0.4149	0.4149
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0457	0.4149	0.4149
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Leishmania major	hypothetical protein, conserved	0.0268	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0725	1	1
Entamoeba histolytica	protein kinase, putative	0.0457	0.4149	0.4149
Brugia malayi	Sex muscle abnormal protein 5	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0268	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0725	1	1
Toxoplasma gondii	STE kinase	0.0268	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Onchocerca volvulus		0.0457	0.4149	0.4149
Onchocerca volvulus		0.0457	0.4149	0.4149
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0457	0.4149	0.4149
Toxoplasma gondii	protein kinase domain-containing protein	0.0268	0	0.5
Entamoeba histolytica	hypothetical protein	0.0279	0.024	0.024
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0268	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Echinococcus granulosus	NCK adaptor protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0457	0.4149	0.4149
Schistosoma mansoni	shc transforming protein	0.0457	0.4149	0.4149
Echinococcus granulosus	N chimaerin	0.0457	0.4149	0.4149
Onchocerca volvulus		0.0725	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine kinase	0.0725	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0457	0.4149	0.4149
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0268	0	0.5
Giardia lamblia	Kinase, NEK	0.0268	0	0.5
Echinococcus granulosus	SH2 motif	0.0457	0.4149	0.4149
Echinococcus granulosus	tyrosine protein kinase shark	0.0725	1	1
Echinococcus multilocularis	N chimaerin	0.0457	0.4149	0.4149
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0457	0.4149	0.4149
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Echinococcus multilocularis	SH2 motif	0.0457	0.4149	0.4149
Giardia lamblia	Kinase	0.0268	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0268	0	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0457	0.4149	0.4149
Giardia lamblia	Protein 21.1	0.0268	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0457	0.4149	0.4149
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0457	0.4149	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus granulosus	hypothetical protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0725	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0457	0.4149	0.4149
Loa Loa (eye worm)	TK/FER protein kinase	0.0725	1	1
Brugia malayi	Protein kinase domain containing protein	0.0725	1	1
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0268	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0268	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0457	0.4149	0.4149
Schistosoma mansoni	tensin	0.0457	0.4149	0.4149
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0457	0.4149	0.4149
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0725	1	1
Brugia malayi	Protein kinase domain containing protein	0.0725	1	1
Echinococcus multilocularis	tensin	0.0457	0.4149	0.4149
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Entamoeba histolytica	protein kinase, putative	0.0279	0.024	0.024
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Onchocerca volvulus		0.0725	1	1
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Loa Loa (eye worm)	STAT protein	0.0457	0.4149	0.4149
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0268	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0457	0.4149	0.4149
Brugia malayi	SH2 domain containing protein	0.0457	0.4149	0.4149
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Schistosoma mansoni	tyrosine kinase	0.0725	1	1
Brugia malayi	RhoGAP domain containing protein	0.0457	0.4149	0.4149
Echinococcus granulosus	SH2 motif	0.0457	0.4149	0.4149
Trichomonas vaginalis	TKL family protein kinase	0.0268	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2980 nM	Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	= 2980 nM	Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	> 100000 nM	Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor	ChEMBL.	9301675
IC50 (binding)	> 100000 nM	Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor	ChEMBL.	9301675

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL104537
PubChem: 10642243

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 174408