Detailed information for compound 1745640

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2403.74 | Formula: C106H175N35O29
  • H donors: 31 H acceptors: 28 LogP: -10.41 Rotable bonds: 90
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N(CC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CCCNC(=N)N)[C@H](CC)C)CCCNC(=N)N)Cc1[nH]cnc1)CO)C[C@H](O[C@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1NC(=O)C)O)O)C)C)CCCNC(=N)N)[C@H](O)C)Cc1ccc(cc1)O)CCCNC(=N)N)NC(=O)CN
  • InChi: 1S/C106H175N35O29/c1-9-55(4)80(94(160)128-64(23-13-37-119-104(111)112)86(152)133-79(54(2)3)101(167)168)134-93(159)75-30-19-42-139(75)98(164)67(25-15-39-121-106(115)116)130-91(157)72-27-18-43-140(72)99(165)69(46-61-48-117-53-122-61)132-88(154)70(51-142)126-78(148)50-136(49-56(5)169-102-82(124-59(8)145)84(150)83(149)76(52-143)170-102)95(161)57(6)123-85(151)63(22-12-36-118-103(109)110)127-89(155)74-29-20-44-141(74)100(166)81(58(7)144)135-87(153)68(45-60-31-33-62(146)34-32-60)131-92(158)73-28-17-41-138(73)97(163)66(24-14-38-120-105(113)114)129-90(156)71-26-16-40-137(71)96(162)65(21-10-11-35-107)125-77(147)47-108/h31-34,48,53-58,63-76,79-84,102,142-144,146,149-150H,9-30,35-47,49-52,107-108H2,1-8H3,(H,117,122)(H,123,151)(H,124,145)(H,125,147)(H,126,148)(H,127,155)(H,128,160)(H,129,156)(H,130,157)(H,131,158)(H,132,154)(H,133,152)(H,134,159)(H,135,153)(H,167,168)(H4,109,110,118)(H4,111,112,119)(H4,113,114,120)(H4,115,116,121)/t55-,56+,57-,58+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76+,79-,80-,81-,82+,83-,84+,102-/m0/s1
  • InChiKey: QQZKMKMFZSIIDR-WWTRRHSQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0031 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0179 0.2308
Brugia malayi ecdysteroid receptor 0.0067 0.0317 0.0424
Onchocerca volvulus Deterin homolog 0.0093 0.0534 0.0523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0317 0.0879
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0093 0.0534 0.1504
Schistosoma mansoni chromobox protein 0.0069 0.0337 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0317 0.0424
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0041 0.0114 0.0399
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0067 0.0317 0.0424
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0033 0.0025
Echinococcus granulosus geminin 0.0168 0.1136 0.3238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0067 0.0317 0.4222
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0063 0.0147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0599 0.0815
Loa Loa (eye worm) hypothetical protein 0.0069 0.0339 0.4524
Brugia malayi hypothetical protein 0.0035 0.0063 0.0071
Loa Loa (eye worm) hypothetical protein 0.0082 0.0445 0.5983
Loa Loa (eye worm) hypothetical protein 0.0101 0.0599 0.8113
Plasmodium falciparum telomerase reverse transcriptase 0.0345 0.257 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0067 0.0317 0.0306
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0091 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0317 0.0366
Brugia malayi MH2 domain containing protein 0.0118 0.0735 0.1005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0067 0.0317 0.0879
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0735 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0033 0.0021
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345 0.257 1
Brugia malayi nuclear receptor NHR-67 0.0031 0.0033 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0067 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0162
Schistosoma mansoni hypothetical protein 0.0069 0.0339 0.0392
Brugia malayi jmjC domain containing protein 0.0035 0.0061 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0067 0.0317 0.0366
Giardia lamblia Kinase, PLK 0.0093 0.0535 0.2046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0067 0.0317 0.4222
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0067 0.0317 0.0879
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0067 0.0317 0.0879
Echinococcus multilocularis chromobox protein 1 0.0069 0.0337 0.0935
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.3484 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0445 0.0601
Echinococcus granulosus neuropeptide s receptor 0.0458 0.3484 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0535 0.7238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0067 0.0317 0.0306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0061 0.0059
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0033 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0067 0.0317 0.4222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0075
Echinococcus granulosus chromobox protein 1 0.0069 0.0337 0.0935
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0033 0.0021
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0033 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0317 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0091 0.1707
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0067 0.0317 0.4222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0067 0.0317 0.0879
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0535 0.1507
Schistosoma mansoni retinoic acid receptor RXR 0.0067 0.0317 0.0366
Echinococcus granulosus inhibitor of apoptosis protein 0.0093 0.0534 0.1504
Echinococcus granulosus jumonji domain containing protein 0.004 0.0104 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0535 0.0524
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0038 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0067 0.0317 0.0424
Plasmodium vivax telomerase reverse transcriptase, putative 0.0345 0.257 1
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0033 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0063 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0153 0.286
Echinococcus multilocularis inhibitor of apoptosis protein 0.0093 0.0534 0.1504
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0058 0.0251 0.5
Loa Loa (eye worm) hypothetical protein 0.0093 0.0534 0.7222
Schistosoma mansoni steroid hormone receptor ad4bp 0.0067 0.0317 0.0366
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0067 0.0317 0.0879
Schistosoma mansoni RAR-like nuclear receptor 0.0067 0.0317 0.0366
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0261 0.344
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0358
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0104 0.0264
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0067 0.0317 0.4222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0599 0.0815
Schistosoma mansoni zinc finger protein 0.0031 0.0033 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0165 0.0183
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0179
Brugia malayi Telomerase reverse transcriptase 0.0918 0.7208 1
Giardia lamblia Telomerase catalytic subunit 0.0345 0.257 1
Schistosoma mansoni nuclear receptor 0.0031 0.0033 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0115 0.2151
Schistosoma mansoni inhibitor of apoptosis protein 0.0093 0.0534 0.0625
Brugia malayi nuclear hormone receptor 0.0067 0.0317 0.0424
Onchocerca volvulus 0.003 0.0024 0.0012
Schistosoma mansoni hypothetical protein 0.0093 0.0534 0.0625
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.029 0.2127 1
Onchocerca volvulus 0.0067 0.0317 0.0306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0067 0.0317 0.0879
Brugia malayi hypothetical protein 0.003 0.0025 0.0018
Echinococcus granulosus expressed protein 0.0369 0.277 0.7942
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0067 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Schistosoma mansoni hypothetical protein 0.0036 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0058 0.0251 0.074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0067 0.0157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0165 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0067 0.0317 0.0424
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0317 0.0424
Schistosoma mansoni nuclear receptor 0.0031 0.0033 0.0025
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0031
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0033 0.0285
Brugia malayi Steroid receptor seven-up type 2 0.0067 0.0317 0.0424
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0535 0.1507
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0115 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0093 0.0534 0.1504
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0317 0.0366
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0033 0.0285
Loa Loa (eye worm) DR-78 0.0031 0.0033 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0706
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0033 0.0059
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0063 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0706
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0063 0.0071
Brugia malayi chromobox protein homolog 3 0.0039 0.0091 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0165 0.0183
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0025 0.0015
Schistosoma mansoni hypothetical protein 0.0168 0.1136 0.1346
Echinococcus multilocularis ecdysone induced protein 78C 0.0067 0.0317 0.0879
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Echinococcus multilocularis caspase 2 0.003 0.0025 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0165 0.0439
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0033 0.0285
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0025 0.0037
Schistosoma mansoni coup transcription factor 0.0067 0.0317 0.0366
Schistosoma mansoni hypothetical protein 0.003 0.0025 0.0015
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0033 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0317 0.0366
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0535 0.1715
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0445 0.1246
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0535 0.1715
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0061 0.0142
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0033 0.0059
Echinococcus multilocularis chromobox protein 1 0.0069 0.0337 0.0935
Brugia malayi photoreceptor-specific nuclear receptor 0.0067 0.0317 0.0424
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0544 0.1531
Brugia malayi hypothetical protein 0.0031 0.0033 0.0029
Brugia malayi steroid hormone receptor 0.0067 0.0317 0.0424
Schistosoma mansoni kinase 0.0048 0.0163 0.0181
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0075
Echinococcus granulosus GPCR family 2 0.0032 0.0038 0.0075
Brugia malayi hypothetical protein 0.0031 0.0033 0.0029
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0337 0.449
Onchocerca volvulus 0.0082 0.0445 0.0433
Onchocerca volvulus Bile acid receptor homolog 0.0067 0.0317 0.0306
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.106 0.8363 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0075
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0544 0.1531
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Brugia malayi Cell death protein 3 precursor 0.003 0.0025 0.0018
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0033 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0165 0.0439
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0063 0.0061
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.027 0.1961 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0063 0.0706
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0061 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Trypanosoma brucei telomerase reverse transcriptase 0.0345 0.257 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0067 0.0317 0.0424
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0031
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0033 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0706
Onchocerca volvulus 0.0031 0.0033 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0067 0.0317 0.0366
Onchocerca volvulus 0.0093 0.0534 0.0523
Echinococcus granulosus caspase 2 0.003 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Brugia malayi tailless protein 0.0031 0.0033 0.0029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0067 0.0317 0.0366
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0115 0.2151
Toxoplasma gondii RNA-directed DNA polymerase 0.0345 0.257 1
Brugia malayi jmjC domain containing protein 0.0095 0.0544 0.0739
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0061 0.0142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0165 0.2109
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0093 0.0534 0.0625
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0038 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0067 0.0317 0.0424
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0445 0.1246
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0031
Loa Loa (eye worm) steroid hormone receptor 0.0067 0.0317 0.4222
Brugia malayi ecdysone receptor 0.0031 0.0033 0.0029
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0535 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0067 0.0317 0.4222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0165 0.0183
Echinococcus granulosus FTZ F1 alpha 0.0067 0.0317 0.0879
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0067 0.0317 0.0879
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0535 0.0627
Treponema pallidum DNA polymerase I (polA) 0.0058 0.0251 0.5
Chlamydia trachomatis DNA polymerase I 0.0058 0.0251 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0063 0.0061
Brugia malayi conserved hypotetical protein 0.0031 0.0033 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0061 0.0059
Brugia malayi nuclear receptor NHR-88 0.0067 0.0317 0.0424
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0735 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0033 0.0059
Brugia malayi Heterochromatin protein 1 0.0069 0.0337 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0317 0.0424
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Echinococcus multilocularis expressed protein 0.0369 0.277 0.7942
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0317 0.0879
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0317 0.0366
Echinococcus granulosus ecdysone induced protein 78C 0.0067 0.0317 0.0879
Onchocerca volvulus 0.003 0.0025 0.0013
Brugia malayi hypothetical protein 0.0035 0.0063 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0535 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345 0.257 1
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.3484 1
Echinococcus multilocularis geminin 0.0168 0.1136 0.3238
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Echinococcus multilocularis GPCR, family 2 0.0032 0.0038 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0067 0.0317 0.0424
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0033 0.0059
Trypanosoma brucei polo-like protein kinase 0.0093 0.0535 0.1715
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0067 0.0317 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0091 0.1707
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0317 0.0424
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0337 0.629
Echinococcus granulosus chromobox protein 1 0.0069 0.0337 0.0935
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.029 0.2127 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0033 0.0059
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0033 0.0029
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0033 0.0029
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0445 0.0518
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0033 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0317 0.0424
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0041 0.0114 0.0399
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Schistosoma mansoni chromobox protein 0.0069 0.0337 0.0389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0317 0.0424
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0317 0.0879
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0025 0.0037
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0093 0.0534 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0067 0.0317 0.0424
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0317 0.0424
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Leishmania major telomerase reverse transcriptase, putative 0.0345 0.257 1
Brugia malayi nuclear receptor RXR 0.0031 0.0033 0.0029
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0535 0.1715
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0067 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0337 0.629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0165 0.0439
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0033 0.0059
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.3484 1
Brugia malayi hypothetical protein 0.0036 0.0067 0.0076
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0058 0.0251 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0706
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.1097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0067 0.0317 0.4222
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0067 0.0317 0.0879
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0033 0.0059
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0093 0.0534 0.0726
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0067 0.0157
Onchocerca volvulus 0.0031 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0093 0.0534 0.7222
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0535 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0153 0.286
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0165 0.0439
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0025 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0067 0.0317 0.0366
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0386 0.0448
Brugia malayi nuclear hormone receptor 0.0031 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0317 0.4222
Brugia malayi nuclear receptor RXR 0.0035 0.0063 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0599 0.8113
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0067 0.0317 0.0366
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0033 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0033 0.0025
Mycobacterium ulcerans DNA polymerase I 0.0058 0.0251 0.0679
Schistosoma mansoni hypothetical protein 0.0168 0.1136 0.1346
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0339 0.0455

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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