Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0207 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0207 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0207 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0207 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0207 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0207 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0207 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0207 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0207 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0207 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0207 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0207 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0207 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0207 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0207 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0207 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0207 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0207 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0207 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0207 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.