Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0163 | 0.1087 | 0.1087 |
Echinococcus granulosus | serotonin transporter | 0.0191 | 0.1336 | 0.0816 |
Onchocerca volvulus | 0.015 | 0.098 | 0.1033 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1336 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0158 | 0.1046 | 0.0452 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0158 | 0.1046 | 0.0452 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0191 | 0.1336 | 0.1161 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0163 | 0.1087 | 0.0504 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0089 | 0.0445 | 0.0252 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0191 | 0.1336 | 0.1336 |
Schistosoma mansoni | serine/threonine protein kinase | 0.015 | 0.098 | 0.098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Schistosoma mansoni | axis inhibition protein axin | 0.0158 | 0.1046 | 0.1046 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0158 | 0.1046 | 0.1046 |
Brugia malayi | Protein kinase domain containing protein | 0.0458 | 0.3645 | 0.3516 |
Brugia malayi | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0089 | 0.0445 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0158 | 0.1046 | 0.1046 |
Echinococcus multilocularis | expressed protein | 0.0158 | 0.1046 | 0.0452 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0158 | 0.1046 | 0.1046 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0158 | 0.1046 | 0.0452 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0158 | 0.1046 | 0.0452 |
Schistosoma mansoni | regulator of G protein signaling | 0.0158 | 0.1046 | 0.1046 |
Brugia malayi | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | RGS-3 protein | 0.0158 | 0.1046 | 0.0865 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0163 | 0.1087 | 0.1087 |
Brugia malayi | PXA domain containing protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0191 | 0.1336 | 0.1161 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0117 | 0.0687 | 0.0499 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.1046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0191 | 0.1336 | 0.1161 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0158 | 0.1046 | 0.0452 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.1046 | 1 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0158 | 0.1046 | 0.0865 |
Brugia malayi | PXA domain containing protein | 0.0158 | 0.1046 | 0.0865 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0158 | 0.1046 | 0.0452 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0158 | 0.1046 | 0.0452 |
Loa Loa (eye worm) | serotonin transporter b | 0.0191 | 0.1336 | 0.1161 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0158 | 0.1046 | 0.0452 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0158 | 0.1046 | 0.0452 |
Echinococcus granulosus | axis inhibition protein axin | 0.0158 | 0.1046 | 0.0452 |
Echinococcus granulosus | axis inhibition protein axin | 0.0158 | 0.1046 | 0.0452 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0117 | 0.0687 | 0.0687 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0158 | 0.1046 | 0.0865 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0158 | 0.1046 | 0.0452 |
Giardia lamblia | Kinase, AGC AKT | 0.0089 | 0.0445 | 0.5 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0158 | 0.1046 | 0.0452 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0158 | 0.1046 | 0.0452 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0191 | 0.1336 | 0.1336 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Echinococcus granulosus | expressed protein | 0.0158 | 0.1046 | 0.0452 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.1046 | 1 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.015 | 0.098 | 0.0369 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1336 | 0.1161 |
Schistosoma mansoni | regulator of G protein signaling | 0.0158 | 0.1046 | 0.1046 |
Schistosoma mansoni | regulator of G protein signaling | 0.0158 | 0.1046 | 0.1046 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0158 | 0.1046 | 1 |
Echinococcus multilocularis | rho associated protein kinase | 0.015 | 0.098 | 0.0369 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.006 | 0.0198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0158 | 0.1046 | 0.1046 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0158 | 0.1046 | 0.0452 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1033 | 0.8631 | 0.8604 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1336 | 0.1161 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.1046 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0191 | 0.1336 | 0.0816 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0158 | 0.1046 | 0.0865 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1191 | 1 | 1 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0158 | 0.1046 | 0.1046 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0158 | 0.1046 | 0.0452 |
Schistosoma mansoni | regulator of G protein signaling | 0.0158 | 0.1046 | 0.1046 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1191 | 1 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1033 | 0.8631 | 0.8604 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0163 | 0.1087 | 0.0504 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0458 | 0.3645 | 0.3516 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1033 | 0.8631 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1033 | 0.8631 | 0.8604 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1033 | 0.8631 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0158 | 0.1046 | 0.1046 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0158 | 0.1046 | 0.0865 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0158 | 0.1046 | 0.0452 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0163 | 0.1087 | 0.0907 |
Toxoplasma gondii | AGC kinase | 0.006 | 0.0198 | 0.5 |
Onchocerca volvulus | 0.0191 | 0.1336 | 1 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0191 | 0.1336 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.