Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0222 | 1 |
Brugia malayi | Ras-related protein ypt4 | 0.0016 | 0.0222 | 0.0223 |
Echinococcus multilocularis | GTP binding protein Parf | 0.0016 | 0.0222 | 0.0223 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0016 | 0.0222 | 0.0299 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0016 | 0.0222 | 0.5 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0222 | 0.0223 |
Entamoeba histolytica | hypothetical protein | 0.0016 | 0.0222 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0016 | 0.0222 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0016 | 0.0222 | 0.5 |
Echinococcus multilocularis | ras-related protein rab-5 | 0.0016 | 0.0222 | 0.0223 |
Onchocerca volvulus | 0.0291 | 0.7419 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0.0222 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0222 | 0.0223 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0386 | 0.9931 | 1 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0016 | 0.0222 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0016 | 0.0222 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0016 | 0.0222 | 0.5 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0016 | 0.0222 | 0.5 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0016 | 0.0222 | 0.5 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.7419 | 0.747 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0016 | 0.0222 | 0.5 |
Echinococcus granulosus | GTP binding protein Parf | 0.0016 | 0.0222 | 0.0222 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.7419 | 0.747 |
Brugia malayi | RAB, member of RAS oncogene family-like 5 | 0.0016 | 0.0222 | 0.0223 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0386 | 0.9931 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0386 | 0.9931 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0016 | 0.0222 | 0.5 |
Echinococcus granulosus | rab protein 3 | 0.0016 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0222 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0222 | 0.0223 |
Onchocerca volvulus | 0.0016 | 0.0222 | 0.0299 | |
Echinococcus multilocularis | rab protein 3 | 0.0016 | 0.0222 | 0.0223 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0.0222 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0.0222 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 8.72 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.