Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | plasmepsin II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0152 | 0 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0152 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0152 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0152 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0152 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0152 | 0 | 0.5 |
Onchocerca volvulus | 0.0152 | 0 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0152 | 0 | 0.5 |
Onchocerca volvulus | 0.0152 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0152 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0682 | 0.4177 | 0.4177 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0682 | 0.4177 | 0.4177 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0971 | 0.6459 | 0.6459 |
Brugia malayi | beta-lactamase | 0.0152 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0152 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0152 | 0 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0682 | 0.4177 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0152 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0152 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0152 | 0 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.142 | 1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0152 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0152 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0682 | 0.4177 | 1 |
Onchocerca volvulus | 0.0152 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.47 uM | Inhibition of recombinant Plasmodium falciparum plasmepsin 2 expressed in Escherichia coli using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate incubated for 40 mins prior to substrate addition measured after 10 mins by FRET-based fluorometric analysis | ChEMBL. | 23466235 |
Inhibition (binding) | = 52.02 % | Inhibition of recombinant Plasmodium falciparum plasmepsin 2 expressed in Escherichia coli using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate at 10 uM incubated for 40 mins prior to substrate addition measured after 10 mins by FRET-based fluorometric analysis | ChEMBL. | 23466235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.